{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:55:50Z","timestamp":1788976550069,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brazil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin E deficiency (VED) is associated with clinical repercussions in preterm newborns (PTN), but low levels are also found in full-term newborns (TN). As this inadequacy can compromise neurogenesis in childhood, studies are needed to assess whether there is a difference in vitamin E status among newborns according to gestational age to provide support for neonatal monitoring protocols. This systematic review presents a synthesis of the available information on the vitamin E status among PTN and TN. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Observational studies that evaluated alpha-tocopherol levels were searched in the databases reported in the protocol registered in PROSPERO (CRD42021165152). The Newcastle\u2013Ottawa Scale was used to assess the methodological quality. Overall, 1809 articles were retrieved; 10 were included in the systematic review. In the PTN, the alpha-tocopherol levels ranged from 3.9 to 8.5 mmol\/L, while in TN, they were 4.9 to 14.9 mmol\/L, and VED ranged from 19% to 100% in newborns. Despite substantial heterogeneity in research methodology and VED classification, the results suggest that the alpha-tocopherol levels among preterm and full-term newborns is below the recommended levels. Our findings demonstrate that further investigations are needed to standardize this classification and to monitor vitamin E status in birth and postnatal with adequate bias control.<\/jats:p>","DOI":"10.3390\/nu14112257","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T23:43:03Z","timestamp":1653867783000},"page":"2257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin E Levels in Preterm and Full-Term Infants: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"D\u00e9bora Gabriela Fernandes","family":"Assun\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Post Graduate Program in Nutrition, Health Science Center, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Thalia Pereira da","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate in Nutrition, Health Science Center, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Dantas de Ara\u00fajo Santos","family":"Camargo","sequence":"additional","affiliation":[{"name":"Maternity School Janu\u00e1rio Cicco (MEJC\/EBSERH), Federal University of Rio Grande do Norte (UFRN), Natal 59012-310, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0184-2061","authenticated-orcid":false,"given":"Ricardo Ney","family":"Cobucci","sequence":"additional","affiliation":[{"name":"Maternity School Janu\u00e1rio Cicco (MEJC\/EBSERH), Federal University of Rio Grande do Norte (UFRN), Natal 59012-310, Brazil"},{"name":"Post Graduate Program of Biotechnology, Potiguar University (UnP), Natal 59056-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2251-5967","authenticated-orcid":false,"given":"Karla Danielly da Silva","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Nutrition, Health Science Center, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(07)76001-6","article-title":"Vitamin E","volume":"76","author":"Mustacich","year":"2007","journal-title":"Vitam. Horm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/iub.1988","article-title":"Vitamin E: Regulatory role of metabolites","volume":"71","author":"Birringer","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_3","unstructured":"Institute of Medicine, Food Nutrition Board (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids: A Report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference, National Academy Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1067\/mob.2002.127131","article-title":"The effect of labor on maternal and fetal vitamins C and E","volume":"187","author":"Woods","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1542\/peds.2013-1684","article-title":"Serum tocopherol levels in very preterm infants after a single dose of vitamin e at birth","volume":"132","author":"Bell","year":"2013","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3945\/an.114.006254","article-title":"Vitamin E inadequacy in humans: Causes and consequences","volume":"5","author":"Traber","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1079\/BJN20041308","article-title":"Vitamins A and E: Metabolism, roles and transfer to offspring","volume":"93","author":"Debier","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3945\/ajcn.110.008367","article-title":"Increased vitamin E intake is associated with higher \u03b1-tocopherol concentration in the maternal circulation but higher \u03b1-carboxyethyl hydroxychroman concentration in the fetal circulation","volume":"93","author":"Didenco","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","unstructured":"Polin, R.A., Rowitch, D.H., Abman, S.H., and Benitz, W.E. (2021). Vitamin E Nutricion in Pregnant and the Newborn Infant. Fetal and Neonatal Physiology, Elsevier. [6th ed.]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21307\/ane-2021-003","article-title":"Effects of vitamin e on neurodegenerative diseases: An update","volume":"81","author":"Icer","year":"2021","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/jn\/nxaa174","article-title":"Infant rhesus macaque brain \u03b1-tocopherol stereoisomer profile is differentially impacted by the source of \u03b1-tocopherol in infant formula","volume":"150","author":"Kuchan","year":"2020","journal-title":"J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/mcn.12232","article-title":"Association between maternal vitamin E status and alpha-tocopherol levels in the newborn and colostrum","volume":"12","author":"Ribeiro","year":"2016","journal-title":"Matern. Child Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1024\/0300-9831.72.3.155","article-title":"Cord blood essential fatty acid and alpha-tocopherol in fullterm newborns in a Northeast Brazil area","volume":"72","author":"Barros","year":"2002","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1017\/S0029665121000914","article-title":"Vitamin E: Necessary nutrient for neural development and cognitive function","volume":"80","author":"Traber","year":"2021","journal-title":"Proc. Nutr. Soc."},{"key":"ref_15","first-page":"1","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_16","unstructured":"World Health Organization (2012). Born Too Soon: The Global Action Report on Preterm Birth, World Health Organization."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","article-title":"Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale","volume":"5","author":"Luchini","year":"2017","journal-title":"World J. Meta-Anal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/0269215513517575","article-title":"A systematic review of factors associated with accidental falls in people with multiple sclerosis: A meta-analytic approach","volume":"28","author":"Prosperini","year":"2014","journal-title":"Clin Rehabil."},{"key":"ref_19","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2013). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analyses 2013, The Ottawa Hospital Research Institute."},{"key":"ref_20","first-page":"793","article-title":"Measurements of serum vitamin E isomers in fullterm and preterm infants","volume":"24","author":"Wu","year":"2001","journal-title":"Chang. Gung. Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/JPM.1999.054","article-title":"Vitamin E status of infants at birth","volume":"27","author":"Chan","year":"1999","journal-title":"J. Perinat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.ejcn.1600838","article-title":"Concentrations of tocopherols and carotenoids in maternal and cord blood plasma","volume":"53","author":"Kiely","year":"1999","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0271-5317(89)80028-4","article-title":"Vitamins A and E; \u03b2-carotene, and proteins in malnourished Nigerian mothers and their newborn infants","volume":"9","author":"Okolo","year":"1989","journal-title":"Nutr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-3782(98)00070-X","article-title":"Influence of caesarean delivery and maternal factors on fat-soluble vitamins in blood from cord and neonates","volume":"53","year":"1998","journal-title":"Early Hum. Dev."},{"key":"ref_25","unstructured":"Rodrigues, K.D.S.R. (2016). Nutritional Status in Vitamins and of Preterm and Term Mothers and Children from Birth to 3 Months Postpartum. [Ph.D. Thesis, Universidade Federal do Rio Grande do Norte]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/ajcn\/40.5.1078","article-title":"An evaluation of vitamin E status in premature infants","volume":"40","author":"Gutcher","year":"1984","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1203\/00006450-199807000-00009","article-title":"Do healthy premature infants fed breast milk need vitamin E supplementation: \u03b1- and \u03b3-tocopherol levels in blood components and buccal mucosal cells","volume":"44","author":"Kaempf","year":"1998","journal-title":"Pediatr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1179\/2046905515Y.0000000017","article-title":"Antioxidant profiles and markers of oxidative stress in preterm neonates","volume":"36","author":"Ghany","year":"2016","journal-title":"Paediatr. Int. Child Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/cea.12490","article-title":"Maternal vitamin D and E intakes during early pregnancy are associated with airway epithelial cell responses in neonates","volume":"45","author":"Miller","year":"2015","journal-title":"Clin. Exp. Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.clnu.2018.02.003","article-title":"Vitamin E status and associations in maternal-infant Dyads in the Midwestern United States","volume":"38","author":"Hanson","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/ajcn\/68.3.662","article-title":"Influence of smoking on vitamin E status during the third trimester of pregnancy and on breast-milk tocopherol concentrations in Spanish women","volume":"68","author":"Ortega","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10520295.2020.1751880","article-title":"Vitamin E effects on developmental disorders in fetuses and cognitive dysfunction in adults following acrylamide treatment during pregnancy","volume":"96","author":"Erdemli","year":"2021","journal-title":"Biotech. Histochem."},{"key":"ref_33","first-page":"1","article-title":"Vitamin E supplementation for prevention of morbidity and mortality in preterm infants","volume":"4","author":"Brion","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.clnu.2018.06.951","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN Guidelines on Pediatric Parenteral Nutrition: Vitamins","volume":"37","author":"Bronsky","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1017\/S0007114516000477","article-title":"\u03b1-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E","volume":"115","author":"Medeiros","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jped.2016.03.007","article-title":"Effect of maternal supplementation with vitamin E on the concentration of -tocopherol in colostrum","volume":"93","author":"Melo","year":"2017","journal-title":"J. Pediatr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/11\/2257\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:20:29Z","timestamp":1760138429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/11\/2257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,28]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["nu14112257"],"URL":"https:\/\/doi.org\/10.3390\/nu14112257","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,28]]}}}