{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:52:17Z","timestamp":1780451537675,"version":"3.54.1"},"reference-count":119,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Algerian Agency for the Research &amp; Development in Health (DGRSDT) and the Algerian Ministry of Higher Education Program","award":["No 03\/03\/03\/10\/008"],"award-info":[{"award-number":["No 03\/03\/03\/10\/008"]}]},{"name":"Algerian Agency for the Research &amp; Development in Health (DGRSDT) and the Algerian Ministry of Higher Education Program","award":["No 208\/ANDRS\/2011"],"award-info":[{"award-number":["No 208\/ANDRS\/2011"]}]},{"name":"Algerian Agency for the Research &amp; Development in Health (DGRSDT) and the Algerian Ministry of Higher Education Program","award":["No 41\/ANDRS\/2011"],"award-info":[{"award-number":["No 41\/ANDRS\/2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The 25-hydroxyvitamin D3 (25OHD3) deficiency in chronic kidney disease (CKD) is associated with immune system dysfunction (pro-inflammatory cytokines storm) through macrophages renal infiltration, oxidative stress (OxS) damage and athero-thromboembolic risk. Conversely, cholecalciferol supplementation (25OHD-S) prevents kidney fibrosis by inhibition of vascular calcification and nephrotic apoptosis (nephrons reduction). The objective of this study was to investigate the pleiotropic effects of 25OHD-S on immunomodulation, antioxidant status and in protecting against thromboembolic events in deficiency CKD Black and White individuals living in the Southern Sahara (SS). The oral 25OHD-S was evaluated in 60,000 IU\/month\/36 weeks versus in 2000 IU\/day\/24 weeks in Black (n = 156) and White (n = 150). Total serum vitamin D was determined by liquid chromatography-tandem mass spectrometry. All biomarkers of pro-inflammatory cytokines (PIC) were assessed by ELISA tests. OxS markers were assessed by Randox kits. Homocysteine and lipoproteine (a) were evaluated by biochemical methods as biomarkers of atherothromboembolic risk. All statistical analyses were performed with Student\u2019s t-test and one-way ANOVA. The Pearson test was used to calculate the correlation coefficient. The means will be significantly different at a level of p value &lt; 0.05. Multiple logistic regressions were performed using Epi-info and Statview software. Vitamin D deficiency alters the PIC profile, OxS damage and atherothrombogenic biomarkers in both SS groups in the same manner; however, these disorders are more acute in Black compared to White SS individuals. The results showed that the serum 25OHD3 concentrations became normal (&gt;75 nmol\/L or &gt;30 ng\/mL) in the two groups. We have shown that the dose and duration of 25OHD-S treatment are not similar in Black SS residents compared to White SS subjects, whilst the same inhabit the south Sahara environment. It appears that a high dose intermittent over a long period (D60: 36 weeks) was more efficient in Black people; while a lower dose for a short time is sufficient (D2: 24 weeks) in their White counterparts. The oral 25OHD-S attenuates PIC overproduction and OxS damage, but does not reduce athero-thromboembolic risk, particularly in Black SS residents.<\/jats:p>","DOI":"10.3390\/nu14112285","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T23:43:03Z","timestamp":1653867783000},"page":"2285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Cholecalciferol Supplementation in Sahara Black People with Chronic Kidney Disease Modulates Cytokine Storm, Oxidative Stress Damage and Athero-Thromboembolic Risk"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-6739","authenticated-orcid":false,"given":"Houda","family":"Zoubiri","sequence":"first","affiliation":[{"name":"Laboratory of Biology and Organisms Physiology, Team of Bioenergetics and Intermediary Metabolism Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria"},{"name":"Biology and Physiology Laboratory, Ecole Nationale Sup\u00e9rieure de Kouba, Algiers 16308, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-3904","authenticated-orcid":false,"given":"Amina","family":"Tahar","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Organisms Physiology, Team of Bioenergetics and Intermediary Metabolism Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"AitAbderrhmane","sequence":"additional","affiliation":[{"name":"Diabetology Unit, Seghir Nekkache Hospital, Ain Na\u00e2dja, Algiers 16105, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messaoud","family":"Saidani","sequence":"additional","affiliation":[{"name":"Clinical Nephrology Exploration Dialysis and Kidney Transplantation Unit, University Hospital Center of Beni Messous, Algiers 16014, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1345-2535","authenticated-orcid":false,"given":"Elhadj-Ahmed","family":"Koceir","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Organisms Physiology, Team of Bioenergetics and Intermediary Metabolism Nutrition and Dietetics in Human Pathologies Post Graduate School, University of Sciences and Technology Houari Boumediene, El Alia, Bab Ezzouar, Algiers 16123, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"ref_1","first-page":"464","article-title":"Color in Northen Africa. Daedalus, Color and Race","volume":"96","author":"Brown","year":"1967","journal-title":"Am. Acad. Arts Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1097\/HJH.0b013e3282dc7549","article-title":"Prevalence and determinants of hypertension in the Algerian Sahara","volume":"25","author":"Temmar","year":"2007","journal-title":"J. Hypertens."},{"key":"ref_3","unstructured":"GBD Chronic Kidney Disease Collaboration (2020). Global, regional, and national burden of chronic kidney disease, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 395, 709\u2013733."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2215\/CJN.12791019","article-title":"Kidney Disease, Race, and GFR Estimation","volume":"15","author":"Levey","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.kint.2020.10.026","article-title":"Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease","volume":"99","author":"Cheung","year":"2021","journal-title":"Kidney Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.mnh.0000172717.49476.80","article-title":"Role of fibroblast growth factor 23 in health and in chronic kidney disease","volume":"14","author":"Fukagawa","year":"2005","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2008.4","article-title":"Prevalence and severity of disordered mineral metabolism in Blacks with chronic kidney disease","volume":"73","author":"Gutierrez","year":"2008","journal-title":"Kidney Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1093\/ndt\/gfs173","article-title":"Racial differences in parathyroid hormone levels in CKD","volume":"27","author":"Isakova","year":"2012","journal-title":"Nephrol Dial. Transpl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2215\/CJN.03500412","article-title":"CRIC Study Investigators: Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC","volume":"7","author":"Gupta","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Petreski, T., Pikon, N., Ekart, R., Hojs, R., and Bevc, S. (2021). Review on Inflammation Markers in Chronic Kidney Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020182"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.5527\/wjn.v2.i2.31","article-title":"Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines","volume":"2","author":"Tbahriti","year":"2013","journal-title":"World J. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ugov\u0161ek, S., and \u0160ebe\u0161tjen, M. (2021). Lipoprotein(a)\u2014The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation. Biomolecules, 12.","DOI":"10.3390\/biom12010026"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.23876\/j.krcp.20.163","article-title":"Implications of oxidative stress in chronic kidney disease: A review on current concepts and therapies","volume":"40","author":"Verma","year":"2021","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9036450","DOI":"10.1155\/2017\/9036450","article-title":"Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?","volume":"2017","author":"Duni","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant Mechanisms in Renal Injury and Disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxid Redox. Signal."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mal\u2019tseva, V.N., Goltyaev, M.V., Turovsky, E.A., and Varlamova, E.G. (2022). Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042360"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cca.2015.08.011","article-title":"Vitamin D and immune function in chronic kidney disease","volume":"450","author":"Liu","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Norris, K.C., Olabisi, O., Barnett, M.E., Meng, Y.X., Martins, D., Obialo, C., Lee, J.E., and Nicholas, S.B. (2018). The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease. Int. J. Environ. Res. Public Health, 15.","DOI":"10.20944\/preprints201810.0472.v1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106084","DOI":"10.1016\/j.jsbmb.2022.106084","article-title":"Novel insight into the role of the vitamin D receptor in the development and function of the immune system","volume":"219","author":"Arora","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/jama.2013.7229","article-title":"Race\/Ethnicity, Serum 25-Hydroxyvitamin D, and Heart Disease","volume":"310","author":"Norris","year":"2013","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bonr.2018.03.004","article-title":"Vitamin D in the Middle East and North Africa","volume":"8","author":"Chakhtoura","year":"2018","journal-title":"Bone Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"790513","DOI":"10.3389\/fmed.2021.790513","article-title":"Non-classical Vitamin D Actions for Renal Protection","volume":"8","author":"Dusso","year":"2021","journal-title":"Front. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lin, P.C., Chou, C.L., Ou, S.H., Fang, T.C., and Chen, J.S. (2021). Systematic Review of Nutrition Supplements in Chronic Kidney Diseases: A GRADE Approach. Nutrients, 13.","DOI":"10.3390\/nu13020469"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1053\/j.ajkd.2014.05.018","article-title":"25-Hydroxyvitamin D Testing and Supplementation in CKD: An NKF-KDOQI Controversies Report","volume":"64","author":"Kramer","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1017\/S1368980012003291","article-title":"Prevalence and determinants of the metabolic syndrome among Tunisian adults: Results of the Transition and Health Impact in North Africa (TAHINA) project","volume":"16","author":"Belfki","year":"2013","journal-title":"Public Health Nutr."},{"key":"ref_27","unstructured":"Favier, J.C., Ireland-Ripert, J., Toque, C., and Findberg, M. (1995). R\u00e9pertoire G\u00e9n\u00e9ral des Aliments, Table de Composition, Tec&Doc, INRA, CNEVA CIQUAL."},{"key":"ref_28","first-page":"755","article-title":"The international physical activity questionnaire (IPAQ): A study of concurrent and construct validity","volume":"9","author":"Oja","year":"2005","journal-title":"Public Health Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1053\/j.ajkd.2018.06.031","article-title":"The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation","volume":"72","author":"Melamed","year":"2018","journal-title":"Am. J. Kidney Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jbspin.2019.04.004","article-title":"Vitamin D Supplementation in France in patients with or at risk for osteoporosis: Recent data and new practices","volume":"87","author":"Souberbielle","year":"2020","journal-title":"Joint. Bone Spine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/s41430-020-00706-3","article-title":"Official recommendations for vitamin D through the life stages in developed countries","volume":"74","author":"Kimball","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12944-019-1121-5","article-title":"The association of metabolic syndrome components and chronic kidney disease in patients with hypertension","volume":"18","author":"Xie","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2337\/diacare.23.1.57","article-title":"Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity","volume":"23","author":"Bonora","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1079\/BJN19910073","article-title":"Body mass index as a measure of body fatness: Age- and sex-specific prediction formulas","volume":"65","author":"Deurenberg","year":"1991","journal-title":"Br. J. Nutr."},{"key":"ref_37","first-page":"55","article-title":"Evaluation of three devices for self measurement of blood pressure according to the revised British Hypertension Society Protocol: The Omron HEM-705CP, Philips HP5332, and Nissei DS-175","volume":"1","author":"Mee","year":"1996","journal-title":"Blood Press. Monit."},{"key":"ref_38","unstructured":"Burtis, C., and Ashwood, E. (2012). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Elsevier Health Sciences. [5th ed.]. ch 26."},{"key":"ref_39","first-page":"226","article-title":"Enzymatic determination of total cholesterol in serum","volume":"12","author":"Roeschlau","year":"1974","journal-title":"Z. Klin. Chem. Klin. Biochem."},{"key":"ref_40","first-page":"1127","article-title":"Long term stable, liquid ready to use monoreagent for the enzymatic assay of serum or plasma triglycerides (GPO-PAP method). AACC Meeting Abstract 34","volume":"39","author":"Siedel","year":"1993","journal-title":"Clin. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/clinchem\/41.5.717","article-title":"Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated \u03b1-cyclodextrin","volume":"41","author":"Sugiuchi","year":"1995","journal-title":"Clin. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"261878","DOI":"10.1155\/2014\/261878","article-title":"Validation of the Friedewald formula in patients with metabolic syndrome","volume":"2014","author":"Knopfholz","year":"2014","journal-title":"Cholesterol"},{"key":"ref_43","first-page":"BC01","article-title":"Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People","volume":"11","author":"Patel","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1524-6175.2004.04237.x","article-title":"Comparison of Commonly Used Assays for the Detection of Microalbuminuria","volume":"6 (11 Suppl. 3)","author":"Busby","year":"2004","journal-title":"J. Clin. Hypertens."},{"key":"ref_45","first-page":"439","article-title":"High-sensitivity C-reactive protein: Clinical importance","volume":"29","author":"Bassuk","year":"2004","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_46","first-page":"222","article-title":"Value of serum fibrinogen levels in the assessment of mechanical prosthetic valve thrombosis","volume":"23","author":"Aykan","year":"2014","journal-title":"J. Heart. Valve Dis."},{"key":"ref_47","unstructured":"Wang, C., Liu, Y., Zhang, M., Yang, F., Xu, F., Shi, S., Zeng, C., Chen, X., Miao, Y., and Liu, Z. (2022). Assessment of the diagnostic value of serum ceruloplasmin for Wilson\u2019s disease in children. Clin. J. Am. Soc. Nephrol., 18."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1258\/0004563011901046","article-title":"Assessment of homocysteine as a cardiovascular risk factor in clinical practice","volume":"38 (Pt 6)","author":"Clarke","year":"2001","journal-title":"Ann. Clin. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1139\/o82-123","article-title":"An improved double antibody radioimmunoassay for the determination of insulin in serum, plasma, and tissue incubation media","volume":"60","author":"Heick","year":"1982","journal-title":"Can. J. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"113010","DOI":"10.1016\/j.jpba.2019.113010","article-title":"Diagnostic methods for the measurement of human TNF-alpha in clinical laboratory","volume":"179","author":"Valaperti","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1\u03b2 as the gatekeeper of inflammation","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"113468","DOI":"10.1016\/j.ab.2019.113468","article-title":"Rapid and sensitive detection of interleukin-6 in serum via time-resolved lateral flow immunoassay","volume":"588","author":"Huang","year":"2020","journal-title":"Anal. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-1759(95)00223-5","article-title":"Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA","volume":"189","author":"Wilkinson","year":"1996","journal-title":"J. Immunol. Methods"},{"key":"ref_54","first-page":"156890","article-title":"IL-18 Serum Level in Adult Onset Still\u2019s Disease: A Marker of Disease Activity","volume":"2012","author":"Colafrancesco","year":"2012","journal-title":"Int. J. Inflam."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/08820139.2014.930477","article-title":"IL-23 plasma level measurement in relapsing remitting multiple sclerosis (RRMS) patients compared to healthy subjects","volume":"44","author":"Shajarian","year":"2015","journal-title":"Immunol. Investig."},{"key":"ref_56","first-page":"77","article-title":"Recommanded method for assaying serum zinc with flame atomic absorption","volume":"44","author":"Arnaud","year":"1986","journal-title":"Ann. Biol. Clin."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase; an enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1016\/S0021-9258(18)51808-1","article-title":"Purification and properties of glutathione reductase of human erythrocytes","volume":"238","author":"Scott","year":"1963","journal-title":"J. Biol. Chem."},{"key":"ref_60","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutatione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.foodchem.2017.02.127","article-title":"Measurement of antioxidant activity with the thiobarbituric acid reactive substances assay","volume":"230","author":"Ghani","year":"2017","journal-title":"Food. Chem."},{"key":"ref_62","first-page":"1565","article-title":"Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2\/D3 using a turbulent flow online extraction technology","volume":"12","author":"Bunch","year":"2009","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/jcem-58-1-91","article-title":"A microassay for 1,25-Dihydroxy-vitamin D not requiring high performance liquid chromatography: Application to clinical studies","volume":"58","author":"Reinhardt","year":"1984","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1210\/jc.2018-01747","article-title":"Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study","volume":"104","author":"Lunyera","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11886-017-0933-z","article-title":"Hypertension in African Americans","volume":"19","author":"Musemwa","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Carlberg, C. (2022). Vitamin D and Pigmented Skin. Nutrients, 14.","DOI":"10.3390\/nu14020325"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1017\/S0007114511007161","article-title":"Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol\/L","volume":"108","author":"Luxwolda","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ki.2013.443","article-title":"Ethnic differences in bone and mineral metabolism in healthy people and patients with CKD","volume":"85","author":"Jorgetti","year":"2014","journal-title":"Kidney Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1763S","DOI":"10.1093\/ajcn\/80.6.1763S","article-title":"Racial\/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women","volume":"80","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.yexcr.2018.02.022","article-title":"Chronic kidney disease induces inflammation by increasing Toll-like receptor-4, cytokine and cathelicidin expression in neutrophils and monocytes","volume":"365","author":"Grabulosa","year":"2018","journal-title":"Exp. Cell. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13578-015-0056-4","article-title":"NF-\u03baB in inflammation and renal diseases","volume":"5","author":"Zhang","year":"2015","journal-title":"Cell Biosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/jcp.24905","article-title":"TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-nB pathway and ERK activation","volume":"230","author":"Berzal","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000202632","article-title":"25-Hydroxyvitamin D Deficiency and Inflammation and Their Association with Hemoglobin Levels in Chronic Kidney Disease","volume":"30","author":"Kendrick","year":"2009","journal-title":"Am. J. Nephrol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40620-014-0113-9","article-title":"Urine interleukin-18 in prediction of acute kidney injury: A systemic review and meta-analysis","volume":"28","author":"Lin","year":"2015","journal-title":"J. Nephrol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1053\/j.ajkd.2005.05.008","article-title":"Interleukin-12 and -18 levels in peritoneal dialysate effluent correlate with the outcome of peritonitis in patients undergoing peritoneal dialysis: Implications for the Type I\/Type II T-cell immune response","volume":"46","author":"Wang","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e142428","DOI":"10.1172\/JCI142428","article-title":"IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation","volume":"131","author":"Li","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e150588","DOI":"10.1172\/JCI150588","article-title":"Tissue-specific therapy in immune-mediated kidney diseases: New ARGuments for targeting the IL-23\/IL-17 axis","volume":"131","author":"Krebs","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2016.12.004","article-title":"Interleukin-1beta as a driver of renal NGAL production","volume":"91","author":"Bonnemaison","year":"2017","journal-title":"Cytokine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1681\/ASN.2013020152","article-title":"Macrophage phenotype controls long-term AKI outcomes-kidney regeneration versus atrophy","volume":"25","author":"Lech","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/10408398.2017.1406333","article-title":"Associations between inflammatory bowel diseases and vitamin D","volume":"59","author":"Barbalho","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1365-2036.2010.04463.x","article-title":"Vitamin D3 treatment of Crohn\u2019s disease patient\u2019s increases stimulated T cell IL-6 production and proliferation","volume":"32","author":"Bartels","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1736","article-title":"A protective function for interleukin 17A in T cell-mediated intestinal inflammation","volume":"10","author":"Kamanaka","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"105456","DOI":"10.1155\/2014\/105456","article-title":"Vitamin D and the Immune System from the Nephrologist\u2019s Viewpoint","volume":"2014","author":"Lang","year":"2014","journal-title":"ISRN Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41598-019-56874-1","article-title":"25-vitamin D reduces inflammation in uremic environment","volume":"10","author":"Brito","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1717S","DOI":"10.1093\/ajcn\/80.6.1717S","article-title":"Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system","volume":"80","author":"Cantorna","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/ajh\/hpu225","article-title":"Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification","volume":"28","author":"Agharazii","year":"2015","journal-title":"Am. J. Hypertens."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"663","DOI":"10.18388\/abp.2006_3294","article-title":"Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review","volume":"53","author":"Zachara","year":"2006","journal-title":"Acta Biochim. Pol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/BJ20041973","article-title":"Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply","volume":"386","author":"Schweizer","year":"2005","journal-title":"Biochem. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/0886022X.2015.1103654","article-title":"The association of oxidant\u2013antioxidant status in patients with chronic renal failure","volume":"38","author":"Aziz","year":"2016","journal-title":"Ren. Fail."},{"key":"ref_90","first-page":"274","article-title":"Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients","volume":"23","author":"Montazerifar","year":"2012","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, Selenoproteins, and Immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/mnfr.200700346","article-title":"Selenium attenuates pro-inflammatory gene expression in macrophages","volume":"52","author":"Vunta","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s10753-018-0928-y","article-title":"1,25-Dihydroxy Vitamin D 3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM 2.5 via the p38\/NF-\u03baB\/NLRP3 Pathway","volume":"42","author":"Xin","year":"2019","journal-title":"Inflammation"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1086\/315916","article-title":"Effects of zinc deficiency on Th1 and Th2 cytokine shifts","volume":"182","author":"Prasad","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2010.11.004","article-title":"Risks and benefits of copper in light of new insights of copper homeostasis","volume":"25","author":"Olivares","year":"2011","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Liu, Y., Tang, R., Xu, Q., Xu, S., Zuo, S., Qiu, J., Zhong, X., Tan, R., and Liu, Y. (2022). High Blood Cu\/Zn Ratio is Associated with Nutritional Risk in Patients Undergoing Maintenance Hemodialysis. Biol. Trace Elem. Res.","DOI":"10.1007\/s12011-022-03104-x"},{"key":"ref_97","first-page":"893","article-title":"Evaluation of plasma concentrations of homocysteine, IL-6, TNF-alpha, hs-CRP, and total antioxidant capacity in patients with end-stage renal failure","volume":"52","author":"Babaei","year":"2014","journal-title":"Acta Med. Iran."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11239-021-02391-w","article-title":"Novara Atherosclerosis Study Group (NAS). Association between vitamin D deficiency and serum Homocysteine levels and its relationship with coronary artery disease","volume":"52","author":"Verdoia","year":"2021","journal-title":"J. Thromb. Thrombolysis."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Hargreaves, M.K., Liu, J., Buchowski, M.S., Patel, K.A., Larson, C.O., Schlundt, D.G., Kenerson, D.M., Hill, K.E., Burk, R.F., and Blot, W.J. (2014). Plasma selenium biomarkers in low income black and white americans from the south eastern United States. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084972"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1039\/d0mt00165a","article-title":"Se deficiency induces renal pathological changes by regulating selenoprotein expression, disrupting redox balance, and activating inflammation","volume":"12","author":"Li","year":"2020","journal-title":"Metallomics"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1194\/jlr.R083626","article-title":"The role of lipoprotein (a) in chronic kidney disease","volume":"59","author":"Hopewell","year":"2018","journal-title":"J. Lipid. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10238-001-8026-z","article-title":"Relationship between lipoprotein (a) levels, oxidative stress, and blood pressure levels in patients with essential hypertension","volume":"1","author":"Antonicelli","year":"2001","journal-title":"Clin. Exp. Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hassan, M.O., Dix-Peek, T., Duarte, R., Dickens, C., Naidoo, S., Vachiat, A., Grinter, S., Manga, P., and Naicker, S. (2020). Association of chronic inflammation and accelerated atherosclerosis among an indigenous black population with chronic kidney disease. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232741"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijcard.2011.09.060","article-title":"Atorvastatin decreases lipoprotein (a): A meta-analysis of randomized trials","volume":"154","author":"Takagi","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/07315724.2013.767659","article-title":"Regular consumption of both vitamin D- and calcium- and vitamin D-fortified yogurt drink is equally accompanied by lowered blood lipoprotein (a) and elevated apoprotein A1 in subjects with type 2 diabetes: A randomized clinical trial","volume":"32","author":"Heravifard","year":"2013","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.nutres.2011.09.005","article-title":"The emerging evidence for vitamin D-mediated regulation of apolipoprotein A-I synthesis","volume":"31","author":"Jaimungal","year":"2011","journal-title":"Nutr. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jsbmb.2016.08.004","article-title":"Physiological functions of Vitamin D in adipose tissue","volume":"165","author":"Abbas","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1467-789X.2012.00986.x","article-title":"Mechanistic roles for calcium and vitamin D in the regulation of body weight","volume":"13","author":"Soares","year":"2012","journal-title":"Obes. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-7075-7-62","article-title":"The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: Secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial","volume":"7","author":"Zhou","year":"2010","journal-title":"Nutr. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1001\/archinte.167.9.893","article-title":"Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain","volume":"167","author":"Caan","year":"2007","journal-title":"Arch. Int. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0884533612445072","article-title":"Do African American Women Require Fewer Calories to Maintain Weight? Results from a Controlled Feeding Trial","volume":"27","author":"Brewer","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajcn\/70.1.13","article-title":"Energy metabolism in African Americans: Potential risk factors for obesity","volume":"70","author":"Weyer","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3945\/ajcn.115.129478","article-title":"Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation","volume":"104","author":"Alzaman","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","article-title":"Decreased bioavailability of vitamin D in obesity","volume":"72","author":"Wortsman","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/j.jrn.2010.01.009","article-title":"Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy","volume":"20","author":"Rydzewski","year":"2010","journal-title":"J. Ren. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1735-1995.175144","article-title":"The effect of vitamin D administration on serum leptin and adiponectin levels in end-stage renal disease patients on hemodialysis with vitamin D deficiency: A placebo-controlled double-blind clinical trial","volume":"21","author":"Naini","year":"2016","journal-title":"J. Res. Med. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1172\/JCI111568","article-title":"Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man","volume":"74","author":"Bell","year":"1984","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/HYPERTENSIONAHA.114.03311","article-title":"CRIC Study Investigators. Serum aldosterone and death, end-stage renal disease, and cardiovascular events in blacks and whites: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study","volume":"64","author":"Deo","year":"2014","journal-title":"Hypertension"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5414\/CNCS110414","article-title":"Forget the phosphorus: A case of hypervitaminosis D-induced symptomatic hypercalcemia","volume":"9","author":"Nguyen","year":"2021","journal-title":"Clin. Nephrol. 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