{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:37:02Z","timestamp":1790462222425,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"inter-regional grant (PHRC) and the regional Council of Burgundy"},{"name":"INRAE, CNRS, Burgundy-Franche-Comt\u00e9 University, Regional Council of Burgundy, France (PARI Agrale 1), FEDER (European Funding for Regional Economic Development), a French Government grant managed by the French National Research Agency (ANR) under the \u2018\u2018Investissements d\u2019Avenir\u2019\u2019 program with reference ANR-11-LABX-0021-01-LipSTIC Labex and Fondation de France\/Fondation de l\u2019Oeil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesthesia, tear film breakup time (TFBUT) measurement and fluorescein corneal staining. Plasma FAs were measured in fasting blood using gas chromatography; (3) Results: A total of 740 subjects with a plasma measurement of 25 FAs were included in this study. The mean age was 82.2 \u00b1 3.7 years, and 62.7% were women. DED was present in 35.0% of participants. We identified a plasma FAs pattern positively associated with DED, characterized by low polyunsaturated fatty acids (PUFAs), high monounsaturated fatty acids (MUFAs) and low saturated fatty acids (SFAs) levels. After adjustment for major confounders, individuals in the upper quartile of the FAs pattern scores compared with those in the lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51\u20134.01), p = 0.001); (4) Conclusion: In this study, we found that a plasma FAs pattern characterized by low PUFAs, high MUFAs and low SFAs was significantly associated with DED in elderly participants.<\/jats:p>","DOI":"10.3390\/nu14112290","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:25:12Z","timestamp":1653956712000},"page":"2290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-6834","authenticated-orcid":false,"given":"Alassane","family":"Seydou","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-8818","authenticated-orcid":false,"given":"Louis","family":"Arnould","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"},{"name":"INSERM, CIC1432, Clinical Epidemiology Unit, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-4845","authenticated-orcid":false,"given":"Pierre-Henry","family":"Gabrielle","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-9876","authenticated-orcid":false,"given":"Florian","family":"Baudin","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-7414","authenticated-orcid":false,"given":"Ines Ben","family":"Ghezala","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"},{"name":"INSERM, CIC1432, Clinical Epidemiology Unit, Dijon University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7265-931X","authenticated-orcid":false,"given":"Alain M.","family":"Bron","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-8079","authenticated-orcid":false,"given":"Niyazi","family":"Acar","sequence":"additional","affiliation":[{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Creuzot-Garcher","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Dijon University Hospital, 21000 Dijon, France"},{"name":"Centre des Sciences du Go\u00fbt et de l\u2019Alimentation, AgroSup Dijon, CNRS, INRAE, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Schaumberg","year":"2003","journal-title":"Am. 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