{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:20:17Z","timestamp":1789147217869,"version":"build-2803163510"},"reference-count":164,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32171171"],"award-info":[{"award-number":["32171171"]}]},{"name":"National Natural Science Foundation of China","award":["31701035"],"award-info":[{"award-number":["31701035"]}]},{"name":"National Natural Science Foundation of China","award":["81903314"],"award-info":[{"award-number":["81903314"]}]},{"name":"National Natural Science Foundation of China","award":["212102310237"],"award-info":[{"award-number":["212102310237"]}]},{"name":"National Natural Science Foundation of China","award":["212300410274"],"award-info":[{"award-number":["212300410274"]}]},{"name":"Key Scientific and Technological Project of Henan Province, China","award":["32171171"],"award-info":[{"award-number":["32171171"]}]},{"name":"Key Scientific and Technological Project of Henan Province, China","award":["31701035"],"award-info":[{"award-number":["31701035"]}]},{"name":"Key Scientific and Technological Project of Henan Province, China","award":["81903314"],"award-info":[{"award-number":["81903314"]}]},{"name":"Key Scientific and Technological Project of Henan Province, China","award":["212102310237"],"award-info":[{"award-number":["212102310237"]}]},{"name":"Key Scientific and Technological Project of Henan Province, China","award":["212300410274"],"award-info":[{"award-number":["212300410274"]}]},{"name":"Natural Science Foundation of Henan Province, China","award":["32171171"],"award-info":[{"award-number":["32171171"]}]},{"name":"Natural Science Foundation of Henan Province, China","award":["31701035"],"award-info":[{"award-number":["31701035"]}]},{"name":"Natural Science Foundation of Henan Province, China","award":["81903314"],"award-info":[{"award-number":["81903314"]}]},{"name":"Natural Science Foundation of Henan Province, China","award":["212102310237"],"award-info":[{"award-number":["212102310237"]}]},{"name":"Natural Science Foundation of Henan Province, China","award":["212300410274"],"award-info":[{"award-number":["212300410274"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Liver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemicals, including polysaccharides, flavonoids, alkaloids, and terpenes, are abundant in foods and medicinal plants and have various bioactivities, such as antioxidation, immunoregulation, and tumor killing. Recent studies have shown that many natural polysaccharides play protective roles in liver disease models in vitro and in vivo, such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver cancer. The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key mechanism in many hepatic pathologies. Therefore, polysaccharides and other types of phytochemicals with activities in ferroptosis regulation provide novel therapeutic strategies for ferroptosis-related liver diseases. This review summarizes our current understanding of the mechanisms of ferroptosis and liver injury and compelling preclinical evidence of natural bioactive polysaccharides and phytochemicals in treating liver disease.<\/jats:p>","DOI":"10.3390\/nu14112303","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:25:12Z","timestamp":1653956712000},"page":"2303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Yijing","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-3688","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/liv.13682","article-title":"Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening","volume":"38","author":"Marcellin","year":"2018","journal-title":"Liver. 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