{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:53Z","timestamp":1787029193149,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["5R03CA184544"],"award-info":[{"award-number":["5R03CA184544"]}]},{"name":"National Institutes of Health","award":["P30 CA023168"],"award-info":[{"award-number":["P30 CA023168"]}]},{"name":"National Institutes of Health","award":["1013613"],"award-info":[{"award-number":["1013613"]}]},{"name":"Purdue University Center for Cancer Research","award":["5R03CA184544"],"award-info":[{"award-number":["5R03CA184544"]}]},{"name":"Purdue University Center for Cancer Research","award":["P30 CA023168"],"award-info":[{"award-number":["P30 CA023168"]}]},{"name":"Purdue University Center for Cancer Research","award":["1013613"],"award-info":[{"award-number":["1013613"]}]},{"name":"USDA National Institute of Food and Agriculture Hatch project","award":["5R03CA184544"],"award-info":[{"award-number":["5R03CA184544"]}]},{"name":"USDA National Institute of Food and Agriculture Hatch project","award":["P30 CA023168"],"award-info":[{"award-number":["P30 CA023168"]}]},{"name":"USDA National Institute of Food and Agriculture Hatch project","award":["1013613"],"award-info":[{"award-number":["1013613"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Preventing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cell-induced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic cancer cells and the cachexia-associated cytokines TNF-\u03b1 and interleukin-6 in 3T3-L1 adipocytes. C26 colon carcinoma-bearing mice were modeled using CAC in vivo. Piceatannol reduced cancer-associated lipolysis by at least 50% in both CCM and cytokine-induced lipolysis in vitro. Further gene and protein analysis confirmed that piceatannol modulated the stability of lipolytic proteins. Moreover, piceatannol protected tumor-bearing mice against weight-loss in early stages of CAC largely through preserving adipose tissue, with no effect on survival. This study demonstrates the use of a dietary compound to preserve adipose in models of early stage CAC and provides groundwork for further investigation of piceatannol or piceatannol-rich foods as alternative medicine in the preservation of body fat mass and future CAC therapy.<\/jats:p>","DOI":"10.3390\/nu14112306","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:25:42Z","timestamp":1653974742000},"page":"2306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-9706","authenticated-orcid":false,"given":"Jonathan C.","family":"Kershaw","sequence":"first","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Department of Public and Allied Health, Bowling Green State University, Bowling Green, OH 43403, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett D.","family":"Elzey","sequence":"additional","affiliation":[{"name":"Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-4659","authenticated-orcid":false,"given":"Xiao-Xuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee-Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nat. 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