{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:18:41Z","timestamp":1784546321682,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It is unclear how ongoing inflammation in Coronavirus Disease 2019 (COVID-19) affects 25-hydroxyvitamin D (25[OH]D) concentration. The objective of our study was to examine serum 25(OH)D levels during COVID-19 pneumonia. Patients were admitted between 1 November and 31 December 2021. Blood samples were taken on admission (day 0) and every 24 h for the subsequent four days (day 1\u20134). On admission, 59% of patients were 25(OH)D sufficient (&gt;30 ng\/mL), and 41% had 25(OH)D inadequacy (&lt;30 ng\/mL). A significant fall in mean 25(OH)D concentration from admission to day 2 (first 48 h) was observed (30.7 ng\/mL vs. 26.4 ng\/mL; p &lt; 0.0001). No subsequent significant change in 25(OH)D concentration was observed between day 2 and 3 (26.4 ng\/mL vs. 25.9 ng\/mL; p = 0.230) and day 3 and day 4 (25.8 ng\/mL vs. 25.9 ng\/mL; p = 0.703). The absolute 25(OH)D change between hospital admission and day 4 was 16% (4.8 ng\/mL; p &lt; 0.0001). On day 4, the number of patients with 25(OH)D inadequacy increased by 18% (p = 0.018). Therefore, serum 25(OH)D concentration after hospital admission in acutely ill COVID-19 patients should be interpreted with caution. Whether low 25(OH)D in COVID-19 reflects tissue level vitamin D deficiency or represents only a laboratory phenomenon remains to be elucidated in further prospective trials of vitamin D supplementation.<\/jats:p>","DOI":"10.3390\/nu14122362","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:55:24Z","timestamp":1655078124000},"page":"2362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum 25-hydroxyvitamin D Concentration Significantly Decreases in Patients with COVID-19 Pneumonia during the First 48 Hours after Hospital Admission"],"prefix":"10.3390","volume":"14","author":[{"given":"Juraj","family":"Smaha","sequence":"first","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ku\u017ema","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1348-3721","authenticated-orcid":false,"given":"Peter","family":"Jackuliak","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nachtmann","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-4773","authenticated-orcid":false,"given":"Filip","family":"Max","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Comenius University Faculty of Pharmacy, Odbojarov 10, 832 32 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tibensk\u00e1","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"},{"name":"Medirex, a.s., Galvaniho 17\/C, 820 16 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Binkley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geriatrics Faculty, Medical Sciences Center, University of Wisconsin, 1300 University Ave, Madison, WI 53706-1510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Payer","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital, Ruzinovska 6, 826 06 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Grant, W.B., Lahore, H., McDonnell, S.L., Baggerly, C.A., French, C.B., Aliano, J.L., and Bhattoa, H.P. (2020). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients, 12.","DOI":"10.20944\/preprints202003.0235.v2"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"D\u2019Avolio, A., Avataneo, V., Manca, A., Cusato, J., De Nicol\u00f2, A., Lucchini, R., Keller, F., and Cant\u00f9, M. (2020). 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients, 12.","DOI":"10.3390\/nu12051359"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-021-06281-7","article-title":"Vitamin D and COVID-19 severity and related mortality: A prospective study in Italy","volume":"21","author":"Campi","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.mayocp.2021.01.001","article-title":"Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients","volume":"96","author":"Angelidi","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijid.2022.01.044","article-title":"Patients with COVID-19 pneumonia with 25(OH)D levels lower than 12 ng\/ml are at increased risk of death","volume":"116","author":"Smaha","year":"2022","journal-title":"Int. J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41366-021-00804-7","article-title":"Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics","volume":"45","author":"Batabyal","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/MCO.0b013e328358fc2b","article-title":"Vitamin D in acute stress and critical illness","volume":"15","author":"Quraishi","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Pludowski, P., Takacs, I., Boyanov, M., Belaya, Z., Diaconu, C.C., Mokhort, T., Zherdova, N., Rasa, I., Payer, J., and Pilz, S. (2022). Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients, 14.","DOI":"10.3390\/nu14071483"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.nutres.2014.12.008","article-title":"Does serum 25-hydroxyvitamin D decrease during acute-phase response? A systematic review","volume":"35","author":"Silva","year":"2015","journal-title":"Nutr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00198-016-3819-9","article-title":"Surgery alters parameters of vitamin D status and other laboratory results","volume":"28","author":"Binkley","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Muscogiuri, G., Barrea, L., Di Somma, C., Laudisio, D., Salzano, C., Pugliese, G., de Alteriis, G., Colao, A., and Savastano, S. (2019). Sex Differences of Vitamin D Status across BMI Classes: An Observational Prospective Cohort Study. Nutrients, 11.","DOI":"10.3390\/nu11123034"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trstmh.2005.06.022","article-title":"Plasma 25-hydroxyvitamin D does not vary over the course of a malarial infection","volume":"100","author":"Newens","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00003246-199207000-00007","article-title":"Blood vitamin concentrations during the acute-phase response","volume":"20","author":"Louw","year":"1992","journal-title":"Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3945\/ajcn.110.008490","article-title":"The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty","volume":"93","author":"Reid","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/jclinpath-2012-201301","article-title":"Vitamin D: A negative acute phase reactant","volume":"66","author":"Waldron","year":"2013","journal-title":"J. Clin. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/07435800.2011.554937","article-title":"Variations in Serum 25-Hydroxyvitamin D during Acute Pancreatitis: An Exploratory Longitudinal Study","volume":"36","author":"Bang","year":"2011","journal-title":"Endocr. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1359\/jbmr.090819","article-title":"Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion","volume":"25","author":"Bertoldo","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1258\/acb.2011.011195","article-title":"Serum 25 hydroxy-vitamin D does not exhibit an acute phase reaction after acute myocardial infarction","volume":"49","author":"Barth","year":"2012","journal-title":"Ann. Clin. Biochem. Int. J. Lab. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13054-020-02911-9","article-title":"Acute respiratory failure in COVID-19: Is it \u201ctypical\u201d ARDS?","volume":"24","author":"Li","year":"2020","journal-title":"Crit. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1148\/radiol.2020200843","article-title":"Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study","volume":"296","author":"Wang","year":"2020","journal-title":"Radiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.beem.2011.03.001","article-title":"Vitamin D metabolism and deficiency in critical illness","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pr. Res. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113955","DOI":"10.1016\/j.bcp.2020.113955","article-title":"Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-\u03b2 induced epithelial to mesenchymal transition","volume":"177","author":"Zheng","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104259","DOI":"10.1016\/j.cellimm.2020.104259","article-title":"Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients","volume":"360","author":"Kloc","year":"2020","journal-title":"Cell. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s00394-020-02411-0","article-title":"Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: A retrospective study","volume":"60","author":"Abrishami","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R216","DOI":"10.1186\/cc9341","article-title":"Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients","volume":"14","author":"Krishnan","year":"2010","journal-title":"Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/jcpt.12742","article-title":"Albumin disposition in critically Ill patients","volume":"43","author":"Erstad","year":"2018","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fendo.2019.00317","article-title":"Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions","volume":"10","author":"Bikle","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1210\/jc.2011-1600","article-title":"Association of Glucocorticoid Use and Low 25-Hydroxyvitamin D Levels: Results from the National Health and Nutrition Examination Survey (NHANES): 2001\u20132006","volume":"96","author":"Skversky","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1677\/joe.0.1640339","article-title":"Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney","volume":"164","author":"Akeno","year":"2000","journal-title":"J. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/ENDO:17:2:109","article-title":"Dexamethasone Enhances Vitamin D-24-Hydroxylase Expression in Osteoblastic (UMR-106) and Renal (LLC-PK1) Cells Treated with 1\u03b1,25-Dihydroxyvitamin D3","volume":"17","author":"Kurahashi","year":"2002","journal-title":"Endocrine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/jcb.22645","article-title":"Novel regulation of 25-hydroxyvitamin D3 24-hydroxylase (24(OH)ase) transcription by glucocorticoids: Cooperative effects of the glucocorticoid receptor, C\/EBP\u03b2, and the Vitamin D receptor in 24(OH)ase transcription","volume":"110","author":"Dhawan","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ronchetti, S., Ricci, E., Migliorati, G., Gentili, M., and Riccardi, C. (2018). How Glucocorticoids Affect the Neutrophil Life. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124090"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/crj.13481","article-title":"Cytological patterns of bronchoalveolar lavage fluid in mechanically ventilated COVID-19 patients on extracorporeal membrane oxygenation","volume":"16","author":"Voicu","year":"2022","journal-title":"Clin. Respir. J."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2362\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:25:22Z","timestamp":1760138722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["nu14122362"],"URL":"https:\/\/doi.org\/10.3390\/nu14122362","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,7]]}}}