{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:06:57Z","timestamp":1787681217110,"version":"build-2784847793"},"reference-count":63,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005802","name":"Romanian National Authority for Scientific Research and Innovation","doi-asserted-by":"publisher","award":["36N\/2019 PN19350202"],"award-info":[{"award-number":["36N\/2019 PN19350202"]}],"id":[{"id":"10.13039\/501100005802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005802","name":"Romanian National Authority for Scientific Research and Innovation","doi-asserted-by":"publisher","award":["9N\/2019, PN 19110303"],"award-info":[{"award-number":["9N\/2019, PN 19110303"]}],"id":[{"id":"10.13039\/501100005802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005802","name":"Romanian National Authority for Scientific Research and Innovation","doi-asserted-by":"publisher","award":["12N\/2019, PN 19070502"],"award-info":[{"award-number":["12N\/2019, PN 19070502"]}],"id":[{"id":"10.13039\/501100005802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Natural ecosystems are polluted with various contaminants, and among these heavy metals raise concerns due to their side effects on both environment and human health. An investigation was conducted on essential oil samples, comparing similar products between seven producers, and the results indicated a wide variation of metal content. The recommended limits imposed by European Union regulations for medicinal plants are exceeded only in Mentha \u00d7 pipperita (Adams, 0.61 mg\/kg). Except for Thymus vulgaris, the multivariate analysis showed a strong correlation between toxic and microelements (p &lt; 0.001). We verified plant species\u2013specific bioaccumulation patterns with non-metric multidimensional scaling analysis. The model showed that Adams, Doterra, Hypericum, and Steaua Divina essential oils originated from plants containing high micro and macroelement (Cu, Mn, Mg, Na) levels. We noted that the cancer risk values for Ni were the highest (2.02 \u00d7 10\u22129\u20137.89 \u00d7 10\u22127). Based on the target hazard quotient, three groups of elements were associated with a possible risk to human health, including As, Hg, and Cd in the first group, Cr, Mn, Ni, and Co in the second, and Zn and Al in the third. Additionally, the challenge of coupling inter-element relationships through a network plot analysis shows a considerable probability of associating toxic metals with micronutrients, which can address cumulative risks for human consumers.<\/jats:p>","DOI":"10.3390\/nu14122363","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:55:24Z","timestamp":1655078124000},"page":"2363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Assessing the Health Risk and the Metal Content of Thirty-Four Plant Essential Oils Using the ICP-MS Technique"],"prefix":"10.3390","volume":"14","author":[{"given":"Andreea Maria","family":"Iordache","sequence":"first","affiliation":[{"name":"National Research and Development Institute for Cryogenics and Isotopic Technologies, ICSI, 4 Uzinei Street, 240050 Ramnicu Valcea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-1950","authenticated-orcid":false,"given":"Constantin","family":"Nechita","sequence":"additional","affiliation":[{"name":"National Research and Development Institute for Forestry \u201cMarin Dracea\u201d Calea Bucovinei, 73 Bis, 725100 Campulung Moldovenesc, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezara","family":"Voica","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Roba","sequence":"additional","affiliation":[{"name":"Biomolecular Physics Department, Faculty of Physics, Kogalniceanu 1, Babes\u2013Bolyai University, 400084 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-9813","authenticated-orcid":false,"given":"Oana Romina","family":"Botoran","sequence":"additional","affiliation":[{"name":"National Research and Development Institute for Cryogenics and Isotopic Technologies, ICSI, 4 Uzinei Street, 240050 Ramnicu Valcea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-6108","authenticated-orcid":false,"given":"Roxana Elena","family":"Ionete","sequence":"additional","affiliation":[{"name":"National Research and Development Institute for Cryogenics and Isotopic Technologies, ICSI, 4 Uzinei Street, 240050 Ramnicu Valcea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1021\/jf060608c","article-title":"Chemical Composition and Antioxidant Properties of Clove Leaf Essential Oil","volume":"54","author":"Jirovetz","year":"2006","journal-title":"J. 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