{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:27:51Z","timestamp":1792402071099,"version":"4.4.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hashemite University","award":["1403938\/10\/13\/16AM"],"award-info":[{"award-number":["1403938\/10\/13\/16AM"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Studies on the association between gastric cancer (GC) and the intake of nutrients in Jordan are very limited, while findings from other reports on the intake of energy and macronutrients are controversial. This study aimed to examine the associations between intake of energy and macronutrients and the risk of GC in a Jordanian population. A case-control study was carried out between March 2015 and August 2018 in four major hospitals, including an oncology center in Jordan. Study participants were 173 cases with incident and histologically confirmed GC and 314 frequency-matched controls. Interview-based questionnaires were used to obtain the study\u2019s information. Data on nutrient intake were collected using a validated Arabic food-frequency questionnaire (FFQ). Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated through multinomial logistic regression and adjusted for potential confounders, including age, marital status, education, body mass index (BMI), smoking, period of smoking, family history of gastric cancer, history of gastric ulcer, and physical activity. Intakes of total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, trans-fat, and omega-6 fatty acids were significantly associated with increased risk of GC. The ORs for the highest versus the lowest tertiles were 6.47 (95% Cl: 3.29\u201312.77), 2.97 (95% CI: 1.58\u20135.58), 6.84 (95% CI: 3.46\u201313.52), 6.19 (95% CI: 3.15\u201312.17), 3.05 (95% CI: 1.58\u20135.88), 8.11 (95% CI: 4.20\u201315.69), and 2.74 (95% CI: 1.47\u20135.09), respectively. No significant association was found for energy, protein, carbohydrate, sugar, fibers, and omega-3 fatty acids. The findings of this study suggest that high intake of selected types of fats was associated with an increased risk of GC.<\/jats:p>","DOI":"10.3390\/nu14122373","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:55:24Z","timestamp":1655078124000},"page":"2373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Macronutrients Intake and Risk of Stomach Cancer: Findings from Case-Control Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Sabika","family":"Allehdan","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, University of Bahrain, Sakhir Campus, Zallaq 32038, Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Bassil","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan M.","family":"Alatrash","sequence":"additional","affiliation":[{"name":"Department of Health Education, Jordan University Hospital, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Al-Jaberi","sequence":"additional","affiliation":[{"name":"Department of General & Pediatric Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hushki","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, King Hussein Cancer Center, Amman 11941, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Rayyan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahammad","family":"Dahoud","sequence":"additional","affiliation":[{"name":"Nursing Department, King Hussein Cancer Center, Amman 11941, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abu-EIteen","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, The Hashemite University, Zarqa 13133, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema F.","family":"Tayyem","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"},{"name":"Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/j.gastro.2021.03.023","article-title":"Global patterns and trends in gastric cancer incidence rates (1988\u20132012) and predictions to 2030","volume":"161","author":"Lin","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global Cancer Statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","unstructured":"Jordan Ministry of Health (2021, September 03). Jordan Cancer Registry: Cancer Incidence in Jordan-2015, Available online: https:\/\/moh.gov.jo\/Echobusv3.0\/SystemAssets\/fbd82c46-6851-40d5-ae9f-651dfc9515ec.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1097\/MCG.0b013e3181a159c4","article-title":"Stomach cancer risk in gastric cancer relatives: Interaction between Helicobacter Pylori infection and family history of gastric cancer for the risk of stomach cancer","volume":"44","author":"Shin","year":"2010","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/CEJ.0b013e32834a7f66","article-title":"The Role of Helicobacter pylori infection in the web of gastric cancer causation","volume":"21","author":"Peleteiro","year":"2012","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.28999","article-title":"Global burden of gastric cancer attributable to Helicobacter pylori","volume":"136","author":"Plummer","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.gtc.2013.01.003","article-title":"Gastric cancer: Epidemiology and risk factors","volume":"42","author":"Forman","year":"2013","journal-title":"Gastroenterol. Clin. North. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/CEJ.0000000000000290","article-title":"Cigarette smoking and gastric cancer in the stomach cancer pooling (StoP) project","volume":"27","author":"Praud","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/bjc.2015.333","article-title":"Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status","volume":"113","author":"Ma","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99013","DOI":"10.18632\/oncotarget.20918","article-title":"Alcohol drinking and gastric cancer risk: A meta-analysis of observational studies","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/jjco\/hyu082","article-title":"Body mass index and risk of gastric cancer: A meta-analysis","volume":"44","author":"Lin","year":"2014","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hashimoto, Y., Hamaguchi, M., Obora, A., Kojima, T., and Fukui, M. (2020). Impact of metabolically healthy obesity on the risk of incident gastric cancer: A population-based cohort study. BMC Endocr. Disord., 20.","DOI":"10.1186\/s12902-019-0472-2"},{"key":"ref_14","unstructured":"World Cancer Research Fund International, and American Institute for Cancer Research (2018). Diet, Nutrition, Physical Activity, and Stomach Cancer, World Cancer Research Fund International. Available online: https:\/\/www.wcrf.org\/wp-content\/uploads\/2021\/02\/stomach-cancer-report.pdf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1008970310963","article-title":"Dietary patterns, nutrient intake and gastric cancer in a high-risk area of Italy","volume":"12","author":"Palli","year":"2001","journal-title":"Cancer Causes Control"},{"key":"ref_16","first-page":"1055","article-title":"Nutrient intake and risk of subtypes of esophageal and gastric cancer","volume":"10","author":"Mayne","year":"2001","journal-title":"Cancer Epidemiol. Prev. Biomark."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.3748\/wjg.v11.i28.4311","article-title":"Nutritional factors and gastric cancer in Zhoushan Islands, China","volume":"11","author":"Qiu","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10552-011-9744-5","article-title":"Dietary habits and gastric cancer risk in north-west Iran","volume":"22","author":"Pakseresht","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/oxfordjournals.aje.a117029","article-title":"Nutritional factors and gastric cancer in Spain","volume":"139","author":"Riboli","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10552-015-0557-9","article-title":"Macronutrient intake and stomach cancer","volume":"26","author":"Hu","year":"2015","journal-title":"Cancer Causes Control"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01719947","article-title":"A case-control study of gastric cancer and nutritional factors in Marseille, France","volume":"11","author":"Pobel","year":"1995","journal-title":"Eur. J. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1207\/S15327914NC421_5","article-title":"Nutrient intakes and adenocarcinoma of the esophagus and distal stomach","volume":"42","author":"Chen","year":"2002","journal-title":"Nutr. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/(SICI)1097-0215(19981109)78:4<415::AID-IJC4>3.0.CO;2-X","article-title":"Nutrient intake patterns and gastric cancer risk: A case-control study in Belgium","volume":"78","author":"Kaaks","year":"1998","journal-title":"Int. J. Cancer"},{"key":"ref_24","first-page":"391","article-title":"Nutrient intake patterns in gastric and colorectal cancers","volume":"14","author":"Jedrychowski","year":"2001","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/(SICI)1097-0215(19991126)83:5<601::AID-IJC5>3.0.CO;2-6","article-title":"Nutrient intake and gastric cancer in Mexico","volume":"83","author":"Ward","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ijc.2910570505","article-title":"Nutrients and gastric cancer risk. A population-based case-control study in Sweden","volume":"57","author":"Hansson","year":"1994","journal-title":"Int. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/(SICI)1097-0142(19970915)80:6<1021::AID-CNCR3>3.0.CO;2-C","article-title":"The role of dietary factors in the intestinal and diffuse histologic subtypes of gastric adenocarcinoma: A case-control study in the U.S","volume":"80","author":"Harrison","year":"1997","journal-title":"Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1207\/s15327914nc4802_4","article-title":"Diet and stomach cancer risk in Warsaw, Poland","volume":"48","author":"Lissowska","year":"2004","journal-title":"Nutr. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.21101\/cejph.a3501","article-title":"Carbohydrate intake, glycemic index, glycemic load and risk of gastric cancer","volume":"17","author":"Nagorni","year":"2009","journal-title":"Cent. Eur. J. Public. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/ijc.21753","article-title":"Glycemic load, glycemic index and carbohydrate intake in relation to risk of stomach cancer: A prospective study","volume":"118","author":"Larsson","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2013.04.001","article-title":"Dietary fiber intake reduces risk for gastric cancer: A meta-analysis","volume":"145","author":"Zhang","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_32","first-page":"1618","article-title":"Cereal fiber intake may reduce risk of gastric adenocarcinomas: The EPIC-EURGAST study","volume":"12","author":"Mendez","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1002\/ijc.33450","article-title":"Dietary fiber intake and risk of gastric cancer: The Japan Public Health Center-based prospective study","volume":"148","author":"Katagiri","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1093\/annonc\/mdp009","article-title":"Macronutrients, fatty acids and cholesterol intake and stomach cancer risk","volume":"20","author":"Lucenteforte","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhu, Y.H., Jeong, S., Wu, M., Jin, Z.Y., Zhou, J.Y., Han, R.Q., Yang, J., Zhang, X.F., Wang, X.S., and Liu, A.M. (2019). Dietary intake of fatty acids, total cholesterol, and stomach cancer in a Chinese population. Nutrients, 11.","DOI":"10.3390\/nu11081730"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e00507","DOI":"10.34172\/jrhs.2021.38","article-title":"Macronutrient\u2019s intake and stomach cancer risk in Iran: A hospital-based case-control study","volume":"21","author":"Toorang","year":"2021","journal-title":"J. Res. Health Sci."},{"key":"ref_37","unstructured":"Lee, R., and Nieman, D. (2013). Nutritional Assessment, McGraw-Hill Companies, Inc.. [6th ed.]."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/oxfordjournals.aje.a113987","article-title":"Physical activity assessment methodology in the Five-City Project","volume":"121","author":"Sallis","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1037\/0033-2909.91.1.55","article-title":"Exercise and obesity: Etiology, physiology, and intervention","volume":"91","author":"Thompson","year":"1982","journal-title":"Psychol. Bull."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jand.2013.08.019","article-title":"Validation of a food frequency questionnaire to assess macronutrient and micronutrient intake among Jordanians","volume":"114","author":"Tayyem","year":"2014","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_41","unstructured":"Takruri, H., Al-Ismail, K., Tayyem, R., and Al-Dabbas, M. (2020). Composition of Local Jordanian Food Dishes, Dar Zuhdi. [1st ed.]."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Willett, W. (2012). Nutritional Epidemiology, Oxford University Press. [3rd ed.].","DOI":"10.1093\/acprof:oso\/9780199754038.001.0001"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3746\/pnf.2021.26.1.30","article-title":"Dietary and lifestyle factors associated with gastric and pancreatic cancers: A case-control study","volume":"26","author":"Allehdan","year":"2021","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1023\/A:1024887411846","article-title":"Case-control study of diet and other risk factors for gastric cancer in Hawaii (United States)","volume":"14","author":"Nomura","year":"2003","journal-title":"Cancer Causes Control"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Han, J., Jiang, Y., Liu, X., Meng, Q., Xi, Q., Zhuang, Q., Han, Y., Gao, Y., Ding, Q., and Wu, G. (2015). Dietary fat intake and risk of gastric cancer: A meta-analysis of observational studies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138580"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1475-2891-13-12","article-title":"Modulation of obesity-induced inflammation by dietary fats: Mechanisms and clinical evidence","volume":"13","author":"Teng","year":"2014","journal-title":"Nutr. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jcsm.12014","article-title":"Hypermetabolism and symptom burden in advanced cancer patients evaluated in a cachexia clinic","volume":"6","author":"Dev","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/mnfr.200700213","article-title":"Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer","volume":"51","author":"Escrich","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1464-5491.2006.01809.x","article-title":"Homocysteinylation of low-density lipoproteins (LDL) from subjects with type 1 diabetes: Effect on oxidative damage of human endothelial cells","volume":"23","author":"Ferretti","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1017\/S0007114509991437","article-title":"Trans-fatty acids and cancer: A mini-review","volume":"102","author":"Smith","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/nutrit\/nuaa061","article-title":"Dietary trans-fatty acid intake in relation to cancer risk: A systematic review and meta-analysis","volume":"79","author":"Michels","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000449205","article-title":"Elaidic acid, a Trans-fatty acid, enhances the metastasis of colorectal cancer cells","volume":"84","author":"Ohmori","year":"2017","journal-title":"Pathobiology"},{"key":"ref_53","first-page":"191","article-title":"Trends of energy and macronutrients intakes in Jordan as obtained by household expenditure and income surveys","volume":"11","author":"Alkurd","year":"2018","journal-title":"J. Agric. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.foodchem.2015.12.074","article-title":"Polycyclic aromatic hydrocarbons\u2019 formation and occurrence in processed food","volume":"199","author":"Singh","year":"2016","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1476-511X-10-127","article-title":"Olive oil intake is inversely related to cancer prevalence: A systematic review and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies","volume":"10","author":"Psaltopoulou","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1021\/jf035241f","article-title":"Comparison of volatile aldehydes present in the cooking fumes of extra virgin olive, olive, and canola oils","volume":"52","author":"Fullana","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biocel.2009.11.010","article-title":"Oleic acid promotes migration on MDA-MB-231 breast cancer cells through an arachidonic acid-dependent pathway","volume":"42","author":"Salazar","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Li, S., Zhou, T., Li, C., Dai, Z., Che, D., Yao, Y., Li, L., Ma, J., Yang, X., and Gao, G. (2014). High metastatic gastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097330"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2373\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:26:01Z","timestamp":1760138761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":59,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["nu14122373"],"URL":"https:\/\/doi.org\/10.3390\/nu14122373","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]}}}