{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:36:38Z","timestamp":1774528598651,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Morinaga Milk Industry Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A high-energy-type oral dietary supplement (ONS), with a low proportion of available carbohydrate (LC-ONS), which contains a slowly digestible carbohydrate, isomaltulose, and is fortified with soluble dietary fiber, was newly developed for individuals with diabetes or prediabetes. This study aimed to evaluate the impact of LC-ONS on blood glucose levels after ingestion in individuals with prediabetes. A single-blind, randomized crossover clinical trial was performed on 20 individuals with prediabetes. After overnight fasting, all subjects ingested one serving (200 kcal\/125 mL) of either LC-ONS (40% energy proportion of available carbohydrates) or standard ONS (ST-ONS, 54% energy proportion of available carbohydrates) on two separate days. The incremental area under the curve of blood glucose levels for 120 min was significantly lower after LC-ONS ingestion compared to ST-ONS (2207 \u00b1 391 mg\/dL\u00b7min (least mean square value \u00b1 standard error) and 3735 \u00b1 391 mg\/dL\u00b7min, respectively; p &lt; 0.001). The LC-ONS showed significantly lower blood glucose levels than the ST-ONS at all time points, except at baseline. Similarly, the incremental area under the curve of plasma insulin was significantly lower after LC-ONS ingestion. These results suggest that LC-ONS is useful as an ONS for energy supply in individuals with postprandial hyperglycemia.<\/jats:p>","DOI":"10.3390\/nu14122386","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:55:24Z","timestamp":1655078124000},"page":"2386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Blood Glucose Response of a Low-Carbohydrate Oral Nutritional Supplement with Isomaltulose and Soluble Dietary Fiber in Individuals with Prediabetes: A Randomized, Single-Blind Crossover Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Eri","family":"Kokubo","sequence":"first","affiliation":[{"name":"Health Care & Nutritional Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Morita","sequence":"additional","affiliation":[{"name":"Health Care & Nutritional Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Medical Corporation Chiseikai Tokyo Center Clinic, 1-1-8 Yaesu, Chuou-ku, Tokyo 192-0397, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Oshio","sequence":"additional","affiliation":[{"name":"R&D Planning Department, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3238-2192","authenticated-orcid":false,"given":"Hiroshi","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Health Care & Nutritional Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-2855","authenticated-orcid":false,"given":"Kazuhiro","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Health Care & Nutritional Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83 Higashihara, Zama, Kanagawa 252-8583, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.maturitas.2018.04.001","article-title":"Optimizing Nutrition in Older People","volume":"112","author":"Clegg","year":"2018","journal-title":"Maturitas"},{"key":"ref_2","first-page":"CD003288","article-title":"Protein and Energy Supplementation in Elderly People at Risk from Malnutrition","volume":"2","author":"Milne","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.2337\/dc21-S012","article-title":"Older Adults: Standards of Medical Care in Diabetes\u20142021","volume":"44","author":"Care","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wang, Q., Zhang, X., Fang, L., Guan, Q., Guan, L., and Li, Q. (2018). Prevalence, Awareness, Treatment and Control of Diabetes Mellitus among Middle-Aged and Elderly People in a Rural Chinese Population: A Cross-Sectional Study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198343"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"k1497","DOI":"10.1136\/bmj.k1497","article-title":"Prevalence of Diagnosed Type 1 and Type 2 Diabetes among US Adults in 2016 and 2017: Population Based Study","volume":"361","author":"Xu","year":"2018","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.2017.7596","article-title":"Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013","volume":"317","author":"Wang","year":"2017","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107950","DOI":"10.1016\/j.diabres.2019.107950","article-title":"Sex and Age Differences in Prevalence and Risk Factors for Prediabetes in Mexican-Americans","volume":"159","author":"Vatcheva","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jdiacomp.2015.09.019","article-title":"Impact of Postprandial Glucose Control on Diabetes-Related Complications: How Is the Evidence Evolving?","volume":"30","author":"Madsbad","year":"2016","journal-title":"J. Diabetes Complicat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.54.1.1","article-title":"Postprandial Hyperglycemia and Diabetes Complications: Is It Time to Treat?","volume":"54","author":"Ceriello","year":"2005","journal-title":"Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00394-012-0462-x","article-title":"Postprandial Glucose, Insulin and Gastrointestinal Hormones in Healthy and Diabetic Subjects Fed a Fructose-Free and Resistant Starch Type IV-Enriched Enteral Formula","volume":"52","author":"Mesa","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e000240","DOI":"10.1136\/bmjdrc-2016-000240","article-title":"Plasma Glucose and Insulin Response to Two Oral Nutrition Supplements in Adults with Type 2 Diabetes Mellitus","volume":"4","author":"Huhmann","year":"2016","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.metabol.2006.09.005","article-title":"Effects of a Palatinose-Based Liquid Diet (Inslow) on Glycemic Control and the Second-Meal Effect in Healthy Men","volume":"56","author":"Arai","year":"2007","journal-title":"Metabolism"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.diabres.2011.05.019","article-title":"Lower Postprandial Glucose Responses at Baseline and after 4 Weeks Use of a Diabetes-Specific Formula in Diabetes Type 2 Patients","volume":"93","author":"Lansink","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.clnu.2017.09.027","article-title":"Glycaemic Response after Intake of a High Energy, High Protein, Diabetes-Specific Formula in Older Malnourished or at Risk of Malnutrition Type 2 Diabetes Patients","volume":"37","author":"Laksir","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/abb.2013.49A001","article-title":"Glycemic Responses to Glycemia-Targeted Specialized-Nutrition Beverages with Varying Carbohydrates Compared to a Standard Nutritional Beverage in Adults with Type 2 Diabetes","volume":"4","author":"Devitt","year":"2013","journal-title":"Adv. Biosci. Biotechnol."},{"key":"ref_16","first-page":"385","article-title":"Report of the Committee of Japan Diabetes Society on the Classification and Diagnostic Criteria of Diabetes Mellitus","volume":"42","author":"Kuzuya","year":"1999","journal-title":"J. Jpn. Diabetes Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13340-020-00439-5","article-title":"Japanese Clinical Practice Guideline for Diabetes 2019","volume":"11","author":"Araki","year":"2020","journal-title":"Diabetol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1210\/jcem-42-4-729","article-title":"Induction of Hypertriglyceridemia by a Low-Fat Diet","volume":"42","author":"Ginsberg","year":"1976","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1507\/endocrj1954.32.933","article-title":"Changes in Blood Glucose and Insulin after an Oral Palatinose Administration in Normal Subjects","volume":"32","author":"Kawai","year":"1985","journal-title":"Endocrinol. Jpn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0278-6915(02)00105-9","article-title":"Isomaltulose (Palatinose\u00ae): A Review of Biological and Toxicological Studies","volume":"40","author":"Lina","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1021\/jf048711u","article-title":"Physicochemical Characterization and Biological Effects of Inulin Enzymatically Synthesized from Sucrose","volume":"53","author":"Wada","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3945\/ajcn.26842","article-title":"Interventions to Lower the Glycemic Response to Carbohydrate Foods with a Low-Viscosity Fiber (Resistant Maltodextrin): Meta-Analysis of Randomized Controlled Trials","volume":"89","author":"Livesey","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","unstructured":"World Health Organization (2003). Food Based Dietary Guidelines in the WHO European Region, World Health Organization."},{"key":"ref_24","unstructured":"(2022, April 04). Overview of Dietary Reference Intakes for Japanese. Available online: https:\/\/www.mhlw.go.jp\/content\/10900000\/000862500.pdf."},{"key":"ref_25","unstructured":"U.S. Department of Agriculture, and U.S. Department of Health and Human Services (2020). Dietary Guidelines for Americans 2020\u20132025."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"jeb164202","DOI":"10.1242\/jeb.164202","article-title":"Fructose-Containing Caloric Sweeteners as a Cause of Obesity and Metabolic Disorders","volume":"221","author":"Tappy","year":"2018","journal-title":"J. Exp. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jhep.2021.02.027","article-title":"Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial","volume":"75","author":"Hochuli","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/dc11-1485","article-title":"Metabolic Effects of Replacing Sucrose by Isomaltulose in Subjects with Type 2 Diabetes: A Randomized Double-Blind Trial","volume":"35","author":"Brunner","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.metabol.2004.03.004","article-title":"Effect of a Novel Palatinose-Based Liquid Balanced Formula (MHN-01) on Glucose and Lipid Metabolism in Male Sprague-Dawley Rats after Short- and Long-Term Ingestion","volume":"53","author":"Arai","year":"2004","journal-title":"Metabolism"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Astina, J., Saphyakhajorn, W., Borompichaichartkul, C., and Sapwarobol, S. (2022). Tapioca Resistant Maltodextrin as a Carbohydrate Source of Oral Nutrition Supplement (ONS) on Metabolic Indicators: A Clinical Trial. Nutrients, 14.","DOI":"10.3390\/nu14050916"},{"key":"ref_31","first-page":"582","article-title":"The Comparative Study of Diabetic Specific Formula and Standard Formula on Postprandial Plasma Glucose Control in Type 2 DM Patients","volume":"97","author":"Buranapin","year":"2014","journal-title":"J. Med. Assoc. Thail."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1475-2891-5-22","article-title":"Acute Effect of Meal Glycemic Index and Glycemic Load on Blood Glucose and Insulin Responses in Humans","volume":"5","author":"Galgani","year":"2006","journal-title":"Nutr. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1017\/S0007114518003628","article-title":"Breakfast Replacement with a Liquid Formula Improves Glycaemic Variability in Patients with Type 2 Diabetes: A Randomised Clinical Trial","volume":"121","author":"Peng","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.clnu.2018.05.007","article-title":"Effectiveness of an Oral Diabetes-Specific Supplement on Nutritional Status, Metabolic Control, Quality or Life, and Functional Status in Elderly Patients. A Multicentre Study","volume":"38","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.2337\/dc15-1891","article-title":"Effects of Palatinose and Sucrose Intake on Glucose Metabolism and Incretin Secretion in Subjects with Type 2 Diabetes","volume":"39","author":"Kemper","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_36","first-page":"210","article-title":"The Impact of Soluble Dietary Fibre on Gastric Emptying, Postprandial Blood Glucose and Insulin in Patients with Type 2 Diabetes","volume":"23","author":"Yu","year":"2014","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1332","DOI":"10.1097\/MD.0000000000001332","article-title":"Assessment of Blood Glucose Regulation and Safety of Resistant Starch Formula-Based Diet in Healthy Normal and Subjects with Type 2 Diabetes","volume":"94","author":"Lin","year":"2015","journal-title":"Medicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jnutbio.2010.03.004","article-title":"High-Fat Diets Rich in Medium- versus Long-Chain Fatty Acids Induce Distinct Patterns of Tissue Specific Insulin Resistance","volume":"22","author":"Bijland","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2337\/diab.41.5.641","article-title":"Dietary Substitution of Medium-Chain Triglycerides Improves Insulin-Mediated Glucose Metabolism in NIDDM Subjects","volume":"41","author":"Eckel","year":"1992","journal-title":"Diabetes"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut Microbial Metabolites in Obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5101423","DOI":"10.1155\/2019\/5101423","article-title":"Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis","volume":"2019","author":"Rao","year":"2019","journal-title":"J. Diabetes Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2386\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:26:51Z","timestamp":1760138811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/12\/2386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,9]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["nu14122386"],"URL":"https:\/\/doi.org\/10.3390\/nu14122386","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,9]]}}}