{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:56:38Z","timestamp":1769122598397,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003750","name":"Union France Alzheimer","doi-asserted-by":"publisher","award":["RAK17019FFA"],"award-info":[{"award-number":["RAK17019FFA"]}],"id":[{"id":"10.13039\/501100003750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Previous studies have highlighted links between a high-glycemic-load (GL) diet and Alzheimer\u2019s disease in apolipoprotein E \u03b54 (APOE4) carriers. However, the impact of high-GL diet on plasma amyloid-\u03b2 (A\u03b2), an Alzheimer\u2019s disease hallmark that can be detected decades before clinical symptomatology, is unknown. This study examined the association between plasma A\u03b2 peptides (A\u03b240, A\u03b242 concentration and A\u03b242\/A\u03b240 ratio) and GL. The influence of the GL of four meal types (breakfast, lunch, afternoon snack, and dinner) was also determined. From the prospective Three-City study, 377 participants with plasma A\u03b2 measurements, and who completed the Food Frequency Questionnaire, were selected. The association between plasma A\u03b2 and GL was tested using an adjusted linear regression model. Lunch GL was associated with a lower plasma A\u03b242 concentration (\u03b2 = \u22122.2 [CI = \u22124.27, \u22120.12], p = 0.038) and lower A\u03b242\/A\u03b240 ratio (\u03b2 = \u22120.009 [CI = \u22120.0172, \u22120.0007], p = 0.034) in the model adjusted for center, age, sex, education level, APOE4 status, energy intake, serum creatinine, total cholesterol, and Mediterranean-like diet. No significant association was found with the GL of the other meal types. These results suggest that dietary GL may independently modulate the plasma A\u03b2 of the APOE4 status. The mechanism underlying diet, metabolic response, and A\u03b2 peptide regulation must be elucidated.<\/jats:p>","DOI":"10.3390\/nu14122485","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:01:22Z","timestamp":1655348482000},"page":"2485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary Glycemic Load and Plasma Amyloid-\u03b2 Biomarkers of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-1229","authenticated-orcid":false,"given":"M\u00e9lissa","family":"Gentreau","sequence":"first","affiliation":[{"name":"Institute of Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, F-34094 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-6984","authenticated-orcid":false,"given":"Michel","family":"Raymond","sequence":"additional","affiliation":[{"name":"ISEM, University of Montpellier, CNRS, EPHE, IRD, F-34095 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Samieri","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, University of Bordeaux, INSERM, BPH, UMR 1219, F-33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-7931","authenticated-orcid":false,"given":"Virginie","family":"Chuy","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, University of Bordeaux, INSERM, BPH, UMR 1219, F-33000 Bordeaux, France"},{"name":"CHU de Bordeaux, P\u00f4le de M\u00e9decine et Chirurgie Bucco-Dentaire, F-33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-1610","authenticated-orcid":false,"given":"Catherine","family":"F\u00e9art","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center, University of Bordeaux, INSERM, BPH, UMR 1219, F-33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-5337","authenticated-orcid":false,"given":"Claire","family":"Berticat","sequence":"additional","affiliation":[{"name":"ISEM, University of Montpellier, CNRS, EPHE, IRD, F-34095 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-226X","authenticated-orcid":false,"given":"Sylvaine","family":"Artero","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, F-34094 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","unstructured":"(2019, June 11). 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