{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:01:03Z","timestamp":1760623263125,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Action \u201cEuropean Joint Programming Initiative \u201cA Healthy Diet for a Healthy Life\u201d (JPI HDHL)\u201d","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"respective national\/regional funding organisations: Fund for Scientific Research (FRS\u2014FNRS, Belgium)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Research Foundation\u2014Flanders (FWO, Belgium)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"INSERM Institut National de la Sant\u00e9","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"et de la Recherche M\u00e9dicale (France)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Federal Ministry of Food and Agriculture","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Federal Office for Agriculture and Food (BLE, Germany)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Federal Ministry of Education and Research Germany","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Ministry of Education, University and Research (MIUR)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Ministry of agricultural, food and forestry policies (MiPAAF), National Institute of Health (ISS)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Ministry of Health (Italy)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"National Institute of Health Carlos III (Spain)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"The Netherlands Organisation for Health Research and Development (ZonMw, The Netherlands)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Austrian Research Promotion Agency (FFG)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Austrian Federal Ministry for Education","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Ministry of Science and Technology (Israel)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]},{"name":"Formas (Sweden)","award":["2819ERA10F","01EA1906A","01EA1906B"],"award-info":[{"award-number":["2819ERA10F","01EA1906A","01EA1906B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fructose intolerance (FI) is a widespread non-genetic condition in which the incomplete absorption of fructose leads to gastro-intestinal disorders. The crucial role of microbial dysbiosis on the onset of these intolerance symptoms together with their persistence under free fructose diets are driving the scientific community towards the use of probiotics as a novel therapeutic approach. In this study, we evaluated the prevalence of FI in a cohort composed of Romanian adults with Functional Grastrointestinal Disorders (FGIDs) and the effectiveness of treatment based on the probiotic formulation EQBIOTA\u00ae (Lactiplantibacillus plantarum CECT 7484 and 7485 and Pediococcus acidilactici CECT 7483). We evaluated the impact of a 30-day treatment both on FI subjects and healthy volunteers. The gastrointestinal symptoms and fecal volatile metabolome were evaluated. A statistically significant improvement of symptoms (i.e., bloating, and abdominal pain) was reported in FI patient after treatment. On the other hand, at the baseline, the content of volatile metabolites was heterogeneously distributed between the two study arms, whereas the treatment led differences to decrease. From our analysis, how some metabolomics compounds were correlated with the improvement and worsening of clinical symptoms clearly emerged. Preliminary observations suggested how the improvement of gastrointestinal symptoms could be induced by the increase of anti-inflammatory and protective substrates. A deeper investigation in a larger patient cohort subjected to a prolonged treatment would allow a more comprehensive evaluation of the probiotic treatment effects.<\/jats:p>","DOI":"10.3390\/nu14122488","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:01:22Z","timestamp":1655348482000},"page":"2488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and Metabolomic Effects of Lactiplantibacillus\u00a0plantarum and Pediococcus acidilactici in Fructose Intolerant Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-1471","authenticated-orcid":false,"given":"Piero","family":"Portincasa","sequence":"first","affiliation":[{"name":"Clinica Medica \u201cA. Murri\u201d, Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-7681","authenticated-orcid":false,"given":"Giuseppe","family":"Celano","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Suolo, della Pianta e Degli Alimenti, Universit\u00e0 Degli Studi di Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Serale","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Suolo, della Pianta e Degli Alimenti, Universit\u00e0 Degli Studi di Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Vitellio","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Suolo, della Pianta e Degli Alimenti, Universit\u00e0 Degli Studi di Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-7046","authenticated-orcid":false,"given":"Francesco Maria","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Suolo, della Pianta e Degli Alimenti, Universit\u00e0 Degli Studi di Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Chira","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, \u2018Iuliu Hatieganu\u2019 University of Medicine and Farmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"David","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, \u2018Iuliu Hatieganu\u2019 University of Medicine and Farmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan L.","family":"Dumitrascu","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, \u2018Iuliu Hatieganu\u2019 University of Medicine and Farmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-884X","authenticated-orcid":false,"given":"Maria","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Suolo, della Pianta e Degli Alimenti, Universit\u00e0 Degli Studi di Bari Aldo Moro, 70126 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jgh.14830","article-title":"Delivery of care for functional gastrointestinal disorders: A systematic review","volume":"35","author":"Basnayake","year":"2020","journal-title":"J. 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