{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:09:48Z","timestamp":1784754588260,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016995","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR21P1"],"award-info":[{"award-number":["JPMJCR21P1"]}],"id":[{"id":"10.13039\/100016995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016995","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJTR20UT"],"award-info":[{"award-number":["JPMJTR20UT"]}],"id":[{"id":"10.13039\/100016995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016995","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JP 21lm0203014"],"award-info":[{"award-number":["JP 21lm0203014"]}],"id":[{"id":"10.13039\/100016995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009029","name":"the Adaptable and Seamless Technology transfer Program through Target-driven R&amp;D","doi-asserted-by":"publisher","award":["JPMJCR21P1"],"award-info":[{"award-number":["JPMJCR21P1"]}],"id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009029","name":"the Adaptable and Seamless Technology transfer Program through Target-driven R&amp;D","doi-asserted-by":"publisher","award":["JPMJTR20UT"],"award-info":[{"award-number":["JPMJTR20UT"]}],"id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009029","name":"the Adaptable and Seamless Technology transfer Program through Target-driven R&amp;D","doi-asserted-by":"publisher","award":["JP 21lm0203014"],"award-info":[{"award-number":["JP 21lm0203014"]}],"id":[{"id":"10.13039\/501100009029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"the Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["JPMJCR21P1"],"award-info":[{"award-number":["JPMJCR21P1"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"the Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["JPMJTR20UT"],"award-info":[{"award-number":["JPMJTR20UT"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"the Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["JP 21lm0203014"],"award-info":[{"award-number":["JP 21lm0203014"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gamma-aminobutyric acid (GABA) is present in the mammalian brain as the main inhibitory neurotransmitter and in foods. It is widely used as a supplement that regulates brain function through stress-reducing and sleep-enhancing effects. However, its underlying mechanisms remain poorly understood, as it is reportedly unable to cross the blood\u2013brain barrier. Here, we explored whether a single peroral administration of GABA affects feeding behavior as an evaluation of brain function and the involvement of vagal afferent nerves. Peroral GABA at 20 and 200 mg\/kg immediately before refeeding suppressed short-term food intake without aversive behaviors in mice. However, GABA administration 30 min before refeeding demonstrated no effects. A rise in circulating GABA concentrations by the peroral administration of 200 mg\/kg GABA was similar to that by the intraperitoneal injection of 20 mg\/kg GABA, which did not alter feeding. The feeding suppression by peroral GABA was blunted by the denervation of vagal afferents. Unexpectedly, peroral GABA alone did not alter vagal afferent activities histologically. The coadministration of a liquid diet and GABA potentiated the postprandial activation of vagal afferents, thereby enhancing postprandial satiation. In conclusion, dietary GABA activates vagal afferents in collaboration with meals or meal-evoked factors and regulates brain function including feeding behavior.<\/jats:p>","DOI":"10.3390\/nu14122492","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:25:11Z","timestamp":1655443511000},"page":"2492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Dietary Gamma-Aminobutyric Acid (GABA) Induces Satiation by Enhancing the Postprandial Activation of Vagal Afferent Nerves"],"prefix":"10.3390","volume":"14","author":[{"given":"Utano","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Nohmi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riho","family":"Sagane","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hai","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7984-8690","authenticated-orcid":false,"given":"Kento","family":"Ohbayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-8913","authenticated-orcid":false,"given":"Atsushi","family":"Yamatsu","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0021-9258(19)50929-2","article-title":"Gamma-Aminobutyric acid in brain: Its formation from glutamic acid","volume":"187","author":"Roberts","year":"1950","journal-title":"J. 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