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decline","award":["PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["PTDC\/SAU-EPI\/32358\/2017"]}]},{"name":"NEON-PC\u2014Neuro-oncological complications of prostate cancer: longitudinal study of cognitive decline","award":["UIDP\/04750\/2020"],"award-info":[{"award-number":["UIDP\/04750\/2020"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["21378"],"award-info":[{"award-number":["21378"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["UIDB\/04750\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["POCI-01-0145-FEDER-032358"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032358"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["PTDC\/SAU-EPI\/32358\/2017"]}]},{"name":"FEDER through the Operational Programme competitiveness and Internationalization, and national funding from FCT and the EPIUnit\u2014Junior Research\u2014Prog Financing","award":["UIDP\/04750\/2020"],"award-info":[{"award-number":["UIDP\/04750\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83\u20130.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77\u20130.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81\u20130.94), and for diffuse (OR = 0.79, 95% CI = 0.69\u20130.89) and intestinal type (OR = 0.88, 95% CI = 0.79\u20130.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit\/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis.<\/jats:p>","DOI":"10.3390\/nu14122555","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:39:55Z","timestamp":1655786395000},"page":"2555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-7365","authenticated-orcid":false,"given":"Giulia","family":"Collatuzzo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-1632","authenticated-orcid":false,"given":"Federica","family":"Teglia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pelucchi","sequence":"additional","affiliation":[{"name":"Branch of Medical Statistics, Biometry, and Epidemiology \u201cG. A. Maccacaro\u201d, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"},{"name":"Branch of Medical Statistics, Biometry, and Epidemiology \u201cG. A. 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Box 1411713135, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Pakseresht","sequence":"additional","affiliation":[{"name":"Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran P.O. Box 1411713135, Iran"},{"name":"Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada"},{"name":"Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal Ulises","family":"Hern\u00e1ndez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malaquias","family":"L\u00f3pez-Cervantes","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, National Autonomous University of Mexico (UNAM), Coyoac\u00e1n 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Bonzi","sequence":"additional","affiliation":[{"name":"Branch of Medical Statistics, Biometry, and Epidemiology \u201cG. A. Maccacaro\u201d, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-9299","authenticated-orcid":false,"given":"Michela","family":"Dalmartello","sequence":"additional","affiliation":[{"name":"Branch of Medical Statistics, Biometry, and Epidemiology \u201cG. A. Maccacaro\u201d, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-2774","authenticated-orcid":false,"given":"Shoichiro","family":"Tsugane","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan"},{"name":"National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo 162-8636, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-2198","authenticated-orcid":false,"given":"M. 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Maccacaro\u201d, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailja","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, San Diego, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"},{"name":"Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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