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obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HRQ2vsQ1 = 1.19 (95% CI 0.81\u20131.75), HRQ3vsQ1 = 1.20 (95% CI 0.81\u20131.78), and HRQ4vsQ1 = 1.02 (95% CI 0.69\u20131.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population.<\/jats:p>","DOI":"10.3390\/nu14132561","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"2561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (\u2018Seguimiento Universidad de Navarra\u2019) Project"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-6620","authenticated-orcid":false,"given":"Rodrigo","family":"S\u00e1nchez-Bayona","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"},{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-4206","authenticated-orcid":false,"given":"Maira","family":"Bes-Rastrollo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u00c1rea de Fisiolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-2528","authenticated-orcid":false,"given":"Cesar I.","family":"Fern\u00e1ndez-L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maite","family":"Bastyr","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-9762","authenticated-orcid":false,"given":"Ainhoa","family":"Madariaga","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-1591","authenticated-orcid":false,"given":"Juan J.","family":"Pons","sequence":"additional","affiliation":[{"name":"IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain"},{"name":"Department of History, Art History, and Geography, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-9808","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u00c1rea de Fisiolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-4434","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red \u00c1rea de Fisiolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","unstructured":"NCD Risk Factor Collaboration (NCD-RisC) (2017). 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