{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:34:52Z","timestamp":1783186492195,"version":"3.54.6"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation-Brazil","award":["20\/13405-2"],"award-info":[{"award-number":["20\/13405-2"]}]},{"name":"S\u00e3o Paulo Research Foundation-Brazil","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brazil","award":["20\/13405-2"],"award-info":[{"award-number":["20\/13405-2"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brazil","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diabetes associated with post-menopause is related to a worse condition of kidney disease. Taking into consideration that this disorder may be regulated by estrogenic mediators, we evaluated the renal protective effect of isoflavone. We investigated the role of the PPAR\u03b3 in the pathogenesis of the disease. For this study, we used diabetic female rats in a postmenopausal model through ovariectomy. The animals were treated with isoflavone or 17\u03b2-estradiol. A dosage was administered to bring on blood glycemia, and through immunohistochemistry, we evaluated the immunoreactivity of PPAR\u03b3 in the endometrium and renal tissue. We analyzed the immunoreactivity of renal injury molecule KIM-1 and the collagen and glycogen densities in the kidney. Through bioinformatics analysis, we observed PPAR\u03b3 and COL1A1 gene expression under the influence of different glucose doses. In particular, we observed that isoflavone and 17\u03b2-estradiol regulate blood glycemia. Renal injury was inhibited by isoflavone, observed by a reduction in KIM-1, along with glycogen accumulation. These benefits of isoflavone may be associated with PPAR\u03b3 overexpression in the kidneys and endometrium of diabetic ovariectomized rats.<\/jats:p>","DOI":"10.3390\/nu14132567","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"2567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPAR\u03b3"],"prefix":"10.3390","volume":"14","author":[{"given":"Adriana Aparecida","family":"Ferraz Carbonel","sequence":"first","affiliation":[{"name":"Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), 740 Edif\u00edcio Lemos Torres\u20142\u00b0 andar, Vila Clementino, S\u00e3o Paulo 04023-900, SP, Brazil"},{"name":"Department of Gynecology, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Andr\u00e9","family":"da Silva","sequence":"additional","affiliation":[{"name":"Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, S\u00e3o Paulo State University (IBILCE\/UNESP), S\u00e3o Jos\u00e9 do Rio Preto 15054-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-5722","authenticated-orcid":false,"given":"Luiz Philipe","family":"de Souza Ferreira","sequence":"additional","affiliation":[{"name":"Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), 740 Edif\u00edcio Lemos Torres\u20142\u00b0 andar, Vila Clementino, S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-2222","authenticated-orcid":false,"given":"Renata Ramos","family":"Vieira","sequence":"additional","affiliation":[{"name":"Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), 740 Edif\u00edcio Lemos Torres\u20142\u00b0 andar, Vila Clementino, S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"dos Santos Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medicine Faculty of University of S\u00e3o Paulo (FMUSP), S\u00e3o Paulo 05403-911, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-1329","authenticated-orcid":false,"given":"Gisela Rodrigues","family":"da Silva Sasso","sequence":"additional","affiliation":[{"name":"Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), 740 Edif\u00edcio Lemos Torres\u20142\u00b0 andar, Vila Clementino, S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"de Jesus Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Structural and Functional Biology Graduate Program, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), 740 Edif\u00edcio Lemos Torres\u20142\u00b0 andar, Vila Clementino, S\u00e3o Paulo 04023-900, SP, Brazil"},{"name":"Department of Gynecology, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-9404","authenticated-orcid":false,"given":"Jos\u00e9 Maria","family":"Soares Junior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medicine Faculty of University of S\u00e3o Paulo (FMUSP), S\u00e3o Paulo 05403-911, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Daniele","family":"Azevedo Lima","sequence":"additional","affiliation":[{"name":"Queen\u2019s Cardiopulmonary Unit (QCPU), Queen\u2019s University, Kingston, ON K7L 3J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-0915","authenticated-orcid":false,"given":"Fernanda Teixeira","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nephrology Division, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo 04023-900, SP, Brazil"},{"name":"Interdisciplinary Graduate Program in Health Sciences, Cruzeiro do Sul University, S\u00e3o Paulo 01506-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/JOE-20-0596","article-title":"100 YEARS OF INSULIN: Towards improved precision and a new classification of diabetes mellitus","volume":"252","author":"Ahlqvist","year":"2022","journal-title":"J. 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