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Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1\u03b2 and tumor necrosis factor-\u03b1 in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.<\/jats:p>","DOI":"10.3390\/nu14132605","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:43:00Z","timestamp":1656024180000},"page":"2605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-7420","authenticated-orcid":false,"given":"Shang-Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Jung","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, An Nan Hospital, China Medical University, Tainan 40447, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ya","family":"Lee","sequence":"additional","affiliation":[{"name":"Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, National Taiwan University, Taipei 106617, Taiwan"},{"name":"Department of Food Science, Nutrition and Nutraceutical Biotechnology, Shih Chien University, Taipei 104, Taiwan"},{"name":"Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-1115","authenticated-orcid":false,"given":"Yen-You","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, China Medical University, Taichung 404333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, China Medical University Beigang Hospital, Yunlin 651012, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-3132","authenticated-orcid":false,"given":"Chun-Hao","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung 404333, 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