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This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver\u2019s detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP\u2014induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.<\/jats:p>","DOI":"10.3390\/nu14132636","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T21:01:41Z","timestamp":1656277301000},"page":"2636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-6698","authenticated-orcid":false,"given":"Baichang","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Nie","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-6150","authenticated-orcid":false,"given":"Hongbin","family":"Si","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","article-title":"Acetaminophen (APAP) hepatotoxicity-isn\u2019t it time for APAP to go away?","volume":"67","author":"Lee","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_2","first-page":"837","article-title":"Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose","volume":"6","author":"Myers","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3320325","DOI":"10.1155\/2021\/3320325","article-title":"Drug-induced liver injury: Clinical evidence of n-acetyl cysteine protective effects","volume":"2021","author":"Ntamo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00204-014-1432-2","article-title":"Acetaminophen hepatotoxicity: An updated review","volume":"89","author":"Lancaster","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jcmgh.2020.11.002","article-title":"Intestinal dysbiosis amplifies acetaminophen-induced acute liver injury","volume":"11","author":"Schneider","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jhep.2018.02.024","article-title":"Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice","volume":"69","author":"Gong","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jpha.2019.11.003","article-title":"Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid","volume":"10","author":"Zheng","year":"2020","journal-title":"J. Pharm. Anal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1124\/dmd.117.077222","article-title":"Effect of probiotics on pharmacokinetics of orally administered acetaminophen in mice","volume":"46","author":"Kim","year":"2018","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3389\/fphar.2020.01303","article-title":"Gut microbiome alters the activity of liver cytochromes P450 in mice with sex-dependent differences","volume":"11","author":"Vavreckova","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"688780","DOI":"10.3389\/fphys.2021.688780","article-title":"Gut microbiota and chemical-induced acute liver injury","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijbiomac.2020.06.055","article-title":"The protective effects of walnut green husk polysaccharide on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in high fructose-induced mice","volume":"162","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11627","DOI":"10.1021\/acs.jafc.9b04323","article-title":"Exopolysaccharides from Lactobacillus buchneri TCP016 attenuate LPS- and d-GalN-induced liver injury by modulating the gut microbiota","volume":"67","author":"Xu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fshw.2021.07.009","article-title":"Mesona chinensis benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice","volume":"11","author":"Hong","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103233","DOI":"10.1016\/j.bioorg.2019.103233","article-title":"Anti-inflammatory flavonoids from root bark of Broussonetia papyrifera in LPS-stimulated Raw264.7 cells","volume":"92","author":"Ryu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_15","first-page":"1609","article-title":"Therapeutic effect of Broussonetia papyrifera and Lonicera japonica in ovalbumin-induced murine asthma model","volume":"8","author":"Hong","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8841706","DOI":"10.1155\/2021\/8841706","article-title":"Polyphenols from Broussonetia papyrifera induce apoptosis of Hepg2 cells via inactivation of ERK and AKT signaling pathways","volume":"2021","author":"Dou","year":"2021","journal-title":"Evid.-Based Complementary Altern. Med. Ecam."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/np800488p","article-title":"Antioxidant lignans from the fruits of Broussonetia papyrifera","volume":"72","author":"Mei","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13065-017-0332-y","article-title":"Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum ait flowers","volume":"11","author":"Yin","year":"2017","journal-title":"Chem. Cent. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijbiomac.2016.06.087","article-title":"Extraction, antioxidant and antibacterial activities of Broussonetia papyrifera fruits polysaccharides","volume":"92","author":"Han","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s11694-018-9721-8","article-title":"Partial characterization and antioxidant activities of polysaccharides sequentially extracted from Dendrobium officinale","volume":"12","author":"Fan","year":"2018","journal-title":"J. Food Meas. Charact."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"112588","DOI":"10.1016\/j.indcrop.2020.112588","article-title":"Extraction and analysis of polysaccharide from Momordica charantia","volume":"153","author":"Yang","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.foodhyd.2018.06.042","article-title":"Pomegranate peel pectin can be used as an effective emulsifier","volume":"85","author":"Yang","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jsfa.11356","article-title":"Structural characterisation and bioactivity of polysaccharides isolated from fermented Dendrobium officinale","volume":"102","author":"Wang","year":"2022","journal-title":"J. Sci. Food Agric."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105694","DOI":"10.1016\/j.phrs.2021.105694","article-title":"Main active components of jiawei gegen qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner","volume":"170","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.7150\/thno.43716","article-title":"Parthenolide ameliorates colon inflammation through regulating Treg\/Th17 balance in a gut microbiota-dependent manner","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.fct.2014.06.011","article-title":"Glutathione s-transferase a1 (Gsta1) release, an early indicator of acute hepatic injury in mice","volume":"71","author":"Liu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jcma.2017.03.007","article-title":"Hepatoprotective effects of ethanol extracts from Folium syringae against acetaminophen-induced hepatotoxicity in vitro and in vivo","volume":"80","author":"Shi","year":"2017","journal-title":"J. Chin. Med. Assoc. JCMA"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, W., Wang, Z., Hou, J., Zhou, Y., He, Y., Jiang, S., Wang, Y., Ren, S., and Li, W. (2018). The liver protection effects of maltol, a flavoring agent, on carbon tetrachloride-induced acute liver injury in mice via inhibiting apoptosis and inflammatory response. Molecules, 23.","DOI":"10.3390\/molecules23092120"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.3389\/fphar.2019.01667","article-title":"Molecular biomarkers in drug-induced liver injury: Challenges and future perspectives","volume":"10","author":"Fu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/03602539208996298","article-title":"Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention","volume":"24","author":"Vermeulen","year":"1992","journal-title":"Drug Metab. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.3748\/wjg.v18.i18.2197","article-title":"Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice","volume":"18","author":"Liu","year":"2012","journal-title":"World J. Gastroentero."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","article-title":"An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen","volume":"98","author":"Chan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1039\/C8FO00378E","article-title":"Protective activity of tovophyllin a, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: Role of Nrf2 activation","volume":"9","author":"Ibrahim","year":"2018","journal-title":"Food Funct."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1039\/D0FO01338B","article-title":"Guavinoside b from Psidium guajava alleviates acetaminophen-induced liver injury via regulating the Nrf2 and JNK signaling pathways","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ijbiomac.2019.11.002","article-title":"Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (Pl-n1) against acetaminophen-induced liver injury in mouse","volume":"154","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/labinvest.2010.127","article-title":"Rhil-1ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure","volume":"90","author":"Hu","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1021\/acs.jafc.7b03361","article-title":"Caspase-mediated anti-apoptotic effect of ginsenoside rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice","volume":"65","author":"Wang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ijbiomac.2018.01.139","article-title":"Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro","volume":"111","author":"Cao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2018.03.107","article-title":"Hepatoprotective effects exerted by Poria cocos polysaccharides against acetaminophen-induced liver injury in mice","volume":"114","author":"Wu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cmet.2020.03.006","article-title":"Gut-resident Lactobacilli activate hepatic Nrf2 and protect against oxidative liver injury","volume":"31","author":"Saeedi","year":"2020","journal-title":"Cell Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e159621","DOI":"10.1128\/spectrum.01596-21","article-title":"Akkermansia muciniphila ameliorates acetaminophen-induced liver injury by regulating gut microbial composition and metabolism","volume":"10","author":"Xia","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4704771","DOI":"10.1155\/2021\/4704771","article-title":"Dietary valine ameliorated gut health and accelerated the development of nonalcoholic fatty liver disease of laying hens","volume":"2021","author":"Jian","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11326","DOI":"10.1021\/ac402390q","article-title":"Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1 h Nmr-based metabolomics in humans","volume":"85","author":"Kim","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1021\/acs.jafc.1c05793","article-title":"In vitro and in vivo studies reveal that hesperetin-7-o-glucoside, a naturally occurring monoglucoside, exhibits strong anti-inflammatory capacity","volume":"69","author":"Wu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"112610","DOI":"10.1016\/j.ecoenv.2021.112610","article-title":"Microcystin-Lr induces ferroptosis in intestine of common carp (Cyprinus carpio)","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotox. Environ. Safe."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1039\/D1FO03003E","article-title":"Dendrobium fimbriatum hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"113544","DOI":"10.1016\/j.jep.2020.113544","article-title":"Hepatoprotective effects of huangqi decoction (Astragali radix and Glycyrrhizae radix et rhizoma) on cholestatic liver injury in mice: Involvement of alleviating intestinal microbiota dysbiosis","volume":"267","author":"Zou","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lee, Y., Chiu, C., Chen, Y., Huang, W., Wang, Y., Chiu, C., Lin, T., Hung, S., Liu, J., and Chuang, H. (2021). Co-treatment with cefotaxime and high-fructose diet inducing nonalcoholic fatty liver disease and gut microbial dysbiosis in mice. Processes, 9.","DOI":"10.3390\/pr9030434"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1021\/acs.jafc.0c00245","article-title":"High-meat-protein high-fat diet induced dysbiosis of gut microbiota and tryptophan metabolism in wistar rats","volume":"68","author":"Shi","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/etm.2021.10385","article-title":"Characteristics of mouse intestinal microbiota during acute liver injury and repair following 50% partial hepatectomy","volume":"22","author":"Shao","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"110530","DOI":"10.1016\/j.foodres.2021.110530","article-title":"Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota","volume":"147","author":"Li","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.gpb.2019.03.001","article-title":"Inulin can alleviate metabolism disorders in ob\/ob mice by partially restoring leptin-related pathways mediated by gut microbiota","volume":"17","author":"Song","year":"2019","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1007\/s00253-020-10665-1","article-title":"Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites","volume":"104","author":"Zou","year":"2020","journal-title":"Appl. Microbiol. Biot."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1039\/D0FO02272A","article-title":"Modulation of gut homeostasis by exopolysaccharides from Aspergillus cristatus (Mk346334), a strain of fungus isolated from fuzhuan brick tea, contributes to immunomodulatory activity in cyclophosphamide-treated mice","volume":"11","author":"Xie","year":"2020","journal-title":"Food Funct."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/13\/2636\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:40:03Z","timestamp":1760139603000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/13\/2636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":55,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["nu14132636"],"URL":"https:\/\/doi.org\/10.3390\/nu14132636","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]}}}