{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:55:07Z","timestamp":1780379707476,"version":"3.54.1"},"reference-count":29,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["26-1"],"award-info":[{"award-number":["26-1"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The association between pollen food allergy syndrome (PFAS) and allergic march remains unclear. In this prospective cohort study of the general population in Tokyo (T-Child Study), we found that sensitization to Cry j 1 and Fel d 1 at ages 5 and 9 years was associated with an increased risk of PFAS at 13 years old (at 5 years, Cry j 1: adjusted odds ratio aOR, 2.74; 95% confidence interval CI, 1.53\u20134.91; Fel d 1: aOR, 2.61; 95% CI, 1.31\u20135.19; at 9 years, Cry j 1: adjusted odds ratio aOR, 4.28; 95% confidence interval CI, 1.98\u20139.25; Fel d 1: aOR, 2.40; 95% CI, 1.33\u20134.32). In particular, sensitization to Bet v 1 at ages 5 and 9 years was associated with a strong risk of PFAS at the age of 13 years (at 5 years: aOR, 10.6; 95% CI, 2.64\u201342.5; at 9 years: aOR, 9.1; 95% CI, 4.71\u201317.6). PFAS risk by age 13 years was increased by any allergic symptom at 5 or 9 years, a combination of wheezing, eczema, and rhinitis, and Bet v 1 sensitization. Our findings suggest that PFAS may be associated with allergic march.<\/jats:p>","DOI":"10.3390\/nu14132658","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:07:02Z","timestamp":1656374822000},"page":"2658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pollen Food Allergy Syndrome in Allergic March"],"prefix":"10.3390","volume":"14","author":[{"given":"Hiroki","family":"Yasudo","sequence":"first","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":false,"given":"Kiwako","family":"Yamamoto-Hanada","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-6371","authenticated-orcid":false,"given":"Limin","family":"Yang","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayako","family":"Saito-Abe","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Sato","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Shimada","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Hirai","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Toyokuni","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-2137","authenticated-orcid":false,"given":"Tatsuki","family":"Fukuie","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-3942","authenticated-orcid":false,"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2222.1987.tb02317.x","article-title":"Oral allergy syndrome (OAS): Symptoms of IgE-mediated hypersensitivity to foods","volume":"17","author":"Amlot","year":"1987","journal-title":"Clin. 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