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This study assessed the prevalence of genetic polymorphisms of folate and cobalamin metabolism-related genes such as MTHFR, MTR, CUBN, and SLC19A1 in pregnant women of a homogeneous Spanish population according to conception, pregnancy, delivery, and newborns complications. This study was conducted on 149 nulliparous women with singleton pregnancies. Sociodemographic and obstetrics variables were recorded, and all patients were genotyped in the MTHFR, MTR, CUBN, and SLC10A1 polymorphisms. The distribution of genotypes detected in this cohort was similar to the population distribution reported in Europe, highlighting that more than 50% of women were carriers of risk alleles of the studied genes. In women with the MTHFR risk allele, there was a statistically significant higher frequency of assisted fertilisation and a higher frequency of preeclampsia and preterm birth. Moreover, CUBN (rs1801222) polymorphism carriers showed a statistically significantly lower frequency of complications during delivery. In conclusion, the prevalence of genetic variants related to folic acid and vitamin B12 metabolic genes in pregnant women is related to mother and neonatal outcomes. Knowing the prevalence of these polymorphisms may lead to a personalised prescription of vitamin intake.<\/jats:p>","DOI":"10.3390\/nu14132702","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"2702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies"],"prefix":"10.3390","volume":"14","author":[{"given":"Gemma","family":"Rodriguez-Carnero","sequence":"first","affiliation":[{"name":"Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"},{"name":"Endocrinology and Nutrition Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Canton-Blanco","sequence":"additional","affiliation":[{"name":"Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"},{"name":"Endocrinology and Nutrition Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Mendizabal","sequence":"additional","affiliation":[{"name":"Patia Europe, 20009 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-5239","authenticated-orcid":false,"given":"Maddi","family":"Arregi","sequence":"additional","affiliation":[{"name":"Patia Europe, 20009 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Zulueta","sequence":"additional","affiliation":[{"name":"Patia Europe, 20009 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureano","family":"Simon","sequence":"additional","affiliation":[{"name":"Patia Europe, 20009 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Macia-Corti\u00f1as","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-8161","authenticated-orcid":false,"given":"Felipe F.","family":"Casanueva","sequence":"additional","affiliation":[{"name":"CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), 28029 Madrid, Spain"},{"name":"Molecular and Cellular Endocrinology Group, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Crujeiras","sequence":"additional","affiliation":[{"name":"Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS\/SERGAS), 15706 Santiago de Compostela, Spain"},{"name":"CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sengpiel, V., Bacelis, J., Myhre, R., Myking, S., Devold Pay, A.S., Haugen, M., Brants\u00e6ter, A.-L., Meltzer, H.M., Nilsen, R.M., and Magnus, P. (2014). Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: A prospective observational cohort study. BMC Pregnancy Childbirth, 14.","DOI":"10.1186\/s12884-014-0375-1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jand.2019.02.016","article-title":"Prepregnancy Dietary Patterns and Their Association with Perinatal Outcomes: A Prospective Cohort Study","volume":"119","author":"Cocate","year":"2019","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bulloch, R.E., Wall, C.R., McCowan, L.M.E., Taylor, R.S., Roberts, C.T., and Thompson, J.M.D. (2020). The Effect of Interactions between Folic Acid Supplementation and One Carbon Metabolism Gene Variants on Small-for-Gestational-Age Births in the Screening for Pregnancy Endpoints (SCOPE) Cohort Study. Nutrients, 12.","DOI":"10.3390\/nu12061677"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10803-010-1057-0","article-title":"Standardized ADOS scores: Measuring severity of autism spectrum disorders in a Dutch sample","volume":"41","author":"Oosterling","year":"2011","journal-title":"J. Autism Dev. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1740-8709.2011.00364.x","article-title":"Folate, vitamin B12, vitamin B6 and homocysteine: Impact on pregnancy outcome","volume":"9","author":"Furness","year":"2013","journal-title":"Matern. Child Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jri.2011.02.004","article-title":"DNA damage and health in pregnancy","volume":"89","author":"Furness","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1530\/rep.1.00523","article-title":"Gene-nutrient interactions during fetal development","volume":"130","author":"Maloney","year":"2005","journal-title":"Reproduction"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0897.2010.00831.x","article-title":"Immunology of pre-eclampsia","volume":"63","author":"Redman","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.3390\/ijerph10094352","article-title":"Neural tube defects, folic acid and methylation","volume":"10","author":"Imbard","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.reprotox.2018.05.004","article-title":"Folic acid and primary prevention of neural tube defects: A review","volume":"80","author":"Hirche","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jdn.10113","article-title":"The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review","volume":"81","author":"Wahbeh","year":"2021","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/nutrit\/nuaa096","article-title":"Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: A systematic review and meta-analysis","volume":"79","author":"Mardali","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s00125-021-05510-7","article-title":"Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: A prospective UK cohort study (PRiDE study)","volume":"64","author":"Saravanan","year":"2021","journal-title":"Diabetologia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jogc.2021.11.017","article-title":"Maternal Vitamin B12 Levels During Pregnancy and Their Effects on Maternal Neurocognitive Symptoms: A Systematic Review","volume":"44","author":"Ramadan","year":"2022","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_15","unstructured":"WHO, and FAO (2004). Vitamin B12. Vitamin and Mineral Requirements in Human Nutrition, World Health Organization. [2nd ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3945\/ajcn.115.107219","article-title":"Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population","volume":"101","author":"Zinck","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.placenta.2009.11.017","article-title":"Expression of folate transporters in human placenta and implications for homocysteine metabolism","volume":"31","author":"Solanky","year":"2010","journal-title":"Placenta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/OGX.0b013e318223614c","article-title":"Folic acid in obstetric practice: A review","volume":"66","author":"Talaulikar","year":"2011","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gene.2013.09.063","article-title":"Folate: Metabolism, genes, polymorphisms and the associated diseases","volume":"533","author":"Nazki","year":"2014","journal-title":"Gene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0029665119000661","article-title":"Addressing optimal folate and related B-vitamin status through the lifecycle: Health impacts and challenges","volume":"78","author":"McNulty","year":"2019","journal-title":"Proc. Nutr. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2018). Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care, 41, S13\u2013S27.","DOI":"10.2337\/dc18-S002"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/HYP.0000000000000208","article-title":"Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association","volume":"79","author":"Garovic","year":"2022","journal-title":"Hypertension"},{"key":"ref_23","first-page":"406","article-title":"Anthropometric growth patterns of preterm and full-term newborns (24\u201342 weeks\u2019 gestational age) at the Hospital Materno-Infantil Vall d\u2019Hebron (Barcelona)(1997\u20132002)","volume":"60","author":"Carrascosa","year":"2004","journal-title":"An. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12263-014-0429-z","article-title":"Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: Their impact on newborn\u2019s anthropometric parameters","volume":"9","author":"Chen","year":"2014","journal-title":"Genes Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/ajcn.83.3.701","article-title":"Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: A comparative study in Mexican, West African, and European populations","volume":"83","author":"Debard","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jmg.40.8.619","article-title":"Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): Findings from over 7000 newborns from 16 areas world wide","volume":"40","author":"Wilcken","year":"2003","journal-title":"J. Med. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Aguilar-Lacasa\u00f1a, S., L\u00f3pez-Flores, I., Gonz\u00e1lez-Alzaga, B., Gim\u00e9nez-Asensio, M.J., Carmona, F.D., Hern\u00e1ndez, A.F., L\u00f3pez Gallego, M.F., Romero-Molina, D., and Lacasa\u00f1a, M. (2021). Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Infant\u2019s Anthropometry at Birth. Nutrients, 13.","DOI":"10.3390\/nu13030831"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/jn.115.223685","article-title":"Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status","volume":"146","author":"Bueno","year":"2016","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00394-016-1365-z","article-title":"Determinants of folate and vitamin B12 plasma levels in the French E3N-EPIC cohort","volume":"57","author":"Matejcic","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/ajcn\/nqy209","article-title":"The 677C\u2192T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population","volume":"108","author":"Shane","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cga.12232","article-title":"Genetic polymorphisms and folate status","volume":"57","author":"Hiraoka","year":"2017","journal-title":"Congenit. Anom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-94-007-2199-9_7","article-title":"Genetic aspects of folate metabolism","volume":"56","author":"Molloy","year":"2012","journal-title":"Subcell. Biochem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3961\/jpmph.2009.42.6.360","article-title":"Gene-diet interaction on cancer risk in epidemiological studies","volume":"42","author":"Lee","year":"2009","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000364866","article-title":"Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta","volume":"78","author":"Shin","year":"2014","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/ijmr.IJMR_275_15","article-title":"Folic acid, one-carbon metabolism & childhood cancer","volume":"146","author":"Moulik","year":"2017","journal-title":"Indian J. Med. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.13499","article-title":"Safety of folic acid","volume":"1414","author":"Field","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2188\/jea.JE20110039","article-title":"Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population","volume":"22","author":"Yila","year":"2012","journal-title":"J. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00394-015-1076-x","article-title":"The impact of MTHFR 677 C\/T genotypes on folate status markers: A meta-analysis of folic acid intervention studies","volume":"56","author":"Colson","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jnutbio.2004.04.003","article-title":"Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women","volume":"15","author":"Shelnutt","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM199901073400102","article-title":"Increased frequency of genetic thrombophilia in women with complications of pregnancy","volume":"340","author":"Kupferminc","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00404-015-3894-8","article-title":"Methylenetetrahydrofolate reductase gene polymorphisms and recurrent pregnancy loss in China: A systematic review and meta-analysis","volume":"293","author":"Chen","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcmd.2004.04.011","article-title":"Thrombophilic polymorphisms in preterm delivery","volume":"33","author":"Valdez","year":"2004","journal-title":"Blood Cells. Mol. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11869-010-0106-3","article-title":"Exposure to particulate matter and adverse birth outcomes: A comprehensive review and meta-analysis","volume":"5","author":"Sapkota","year":"2012","journal-title":"Air Qual. Atmos. Health"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00404-015-3945-1","article-title":"Association between periodontitis, periodontopathogens and preterm birth: Is it real?","volume":"294","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jiang, M., Qiu, J., Zhou, M., He, X., Cui, H., Lerro, C., Lv, L., Lin, X., Zhang, C., and Zhang, H. (2015). Exposure to cooking fuels and birth weight in Lanzhou, China: A birth cohort study. BMC Public Health, 15.","DOI":"10.1186\/s12889-015-2038-1"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6652231","DOI":"10.1155\/2021\/6652231","article-title":"A Novel Review of Homocysteine and Pregnancy Complications","volume":"2021","author":"Dai","year":"2021","journal-title":"Biomed Res. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.mam.2007.01.002","article-title":"Absorption, transport, and tissue delivery of vitamin E","volume":"28","author":"Rigotti","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1021\/jf904464u","article-title":"Analysis of multiple metabolites of tocopherols and tocotrienols in mice and humans","volume":"58","author":"Zhao","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"558598","DOI":"10.3389\/fnut.2020.558598","article-title":"Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes-A Narrative Review of the Case of Vitamins","volume":"7","author":"Niforou","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.arcmed.2013.01.011","article-title":"Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and risk of preeclampsia: An updated meta-analysis based on 51 studies","volume":"44","author":"Wang","year":"2013","journal-title":"Arch. Med. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.preghy.2020.02.001","article-title":"Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia","volume":"20","author":"Osunkalu","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhao, J.-Y., Wang, F., Peng, Q.-Q., Hou, J., Sun, S.-N., Gui, Y.-H., Duan, W.-Y., Qiao, B., and Wang, H.-Y. (2014). A genetic variant in vitamin B12 metabolic genes that reduces the risk of congenital heart disease in Han Chinese populations. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088332"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1093\/hmg\/ddp428","article-title":"Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway","volume":"18","author":"Hazra","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"619176","DOI":"10.3389\/fendo.2021.619176","article-title":"Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India","volume":"12","author":"Behere","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1007\/s11033-013-2810-1","article-title":"The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: A case-control study and a meta-analysis","volume":"40","author":"Bosco","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e929911","DOI":"10.12659\/MSM.929911","article-title":"The roles of reduced folate carrier-1 (RFC1) A8oG (rs1051266) polymorphism in congenital heart disease: A meta-analysis","volume":"27","author":"Yi","year":"2021","journal-title":"Med. Sci. Monit."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/13\/2702\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:40:16Z","timestamp":1760139616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/13\/2702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":56,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["nu14132702"],"URL":"https:\/\/doi.org\/10.3390\/nu14132702","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}