{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:48:58Z","timestamp":1792043338420,"version":"4.4.0"},"reference-count":75,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Abnormalities in lipid metabolism have been linked to the development of obesity. We used a nutrigenetic approach to establish a link between lipids and obesity in Asian Indians, who are known to have a high prevalence of central obesity and dyslipidaemia. A sample of 497 Asian Indian individuals (260 with type 2 diabetes and 237 with normal glucose tolerance) (mean age: 44 \u00b1 10 years) were randomly chosen from the Chennai Urban Rural Epidemiological Study (CURES). Dietary intake was assessed using a previously validated questionnaire. A genetic risk score (GRS) was constructed based on cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) genetic variants. There was a significant interaction between GRS and saturated fatty acid (SFA) intake on waist circumference (WC) (Pinteraction = 0.006). Individuals with a low SFA intake (\u226423.2 g\/day), despite carrying \u22652 risk alleles, had a smaller WC compared to individuals carrying &lt;2 risk alleles (Beta = \u22120.01 cm; p = 0.03). For those individuals carrying \u22652 risk alleles, a high SFA intake (&gt;23.2 g\/day) was significantly associated with a larger WC than a low SFA intake (\u226423.2 g\/day) (Beta = 0.02 cm, p = 0.02). There were no significant interactions between GRS and other dietary factors on any of the measured outcomes. We conclude that a diet low in SFA might help reduce the genetic risk of central obesity confirmed by CETP and LPL genetic variants. Conversely, a high SFA diet increases the genetic risk of central obesity in Asian Indians.<\/jats:p>","DOI":"10.3390\/nu14132713","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T22:43:28Z","timestamp":1656542608000},"page":"2713","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Lipid Genetic Risk Score and Saturated Fatty Acid Intake on Central Obesity in an Asian Indian Population"],"prefix":"10.3390","volume":"14","author":[{"given":"Ramatu","family":"Wuni","sequence":"first","affiliation":[{"name":"Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-4075","authenticated-orcid":false,"given":"Evelyn","family":"Adela Nathania","sequence":"additional","affiliation":[{"name":"Indonesia International Institute for Life Sciences, JI. Pulomas Barat Kav. 88, Jakarta Timur 13210, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok K.","family":"Ayyappa","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagarajan","family":"Lakshmipriya","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandaswamy","family":"Ramya","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Gayathri","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunasekaran","family":"Geetha","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Mohan","family":"Anjana","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, India"},{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"},{"name":"Dr. Mohan\u2019s Diabetes Specialties Centre, IDF Centre of Excellence in Diabetes Care, Gopalapuram, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter G. C.","family":"Kuhnle","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Radha","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-6210","authenticated-orcid":false,"given":"Viswanathan","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, Chennai 603103, India"},{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"},{"name":"Dr. Mohan\u2019s Diabetes Specialties Centre, IDF Centre of Excellence in Diabetes Care, Gopalapuram, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasudevan","family":"Sudha","sequence":"additional","affiliation":[{"name":"Department of Food, Nutrition and Dietetics Research, Madras Diabetes Research Foundation, Chennai 600086, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-8930","authenticated-orcid":false,"given":"Karani Santhanakrishnan","family":"Vimaleswaran","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK"},{"name":"The Institute for Food, Nutrition, and Health (IFNH), University of Reading, Reading RG6 6AP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12986-016-0098-6","article-title":"Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population","volume":"13","author":"Vimaleswaran","year":"2016","journal-title":"Nutr. 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