{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:43:36Z","timestamp":1792842216808,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Earlier studies reported that long-term treatment with thymoquinone (TQ) at a high dose (20 mg\/kg) exerts a cardioprotective effect against isoproterenol (ISO)-triggered myocardial infarction (MI) in rats. In the present study, we tested the hypothesis that TQ, as a potent molecule, can exhibit cardioprotective effects at the lower dose for a short-term regimen. The rats were administered with TQ (5 mg\/kg, intraperitoneal) at the 4 h interval for 2 days. ISO (100 mg\/kg\/day, subcutaneous) was given for 2 days to produce MI. ISO challenge results in deformation in ECG wave front, elevated left ventricular (LV) end-diastolic pressure, and reduced LVdP\/dtmax and LVdP\/dtmin. The levels of the cardiac biomarker in serum, such as creatine kinase MB, alanine aminotransferase, and aspartate aminotransferase, were increased. In the myocardium, a rise in malonaldehyde and decreased superoxide dismutase, glutathione, and catalase contents were observed. Furthermore, increased levels of tumor necrotic factor-\u03b1, interleukin-6, and interleukin-1\u03b2 were observed in the myocardium. TQ pretreatment significantly normalized alterations in hemodynamic parameters, strengthened the antioxidant defense system, and decreased the contents of pro-inflammatory cytokines and hepatic enzymes as compared to the ISO group. Based on the results, TQ appears to be cardioprotective at low doses, and effective even administered for a shorter duration.<\/jats:p>","DOI":"10.3390\/nu14132742","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:21:50Z","timestamp":1656634910000},"page":"2742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thymoquinone Produces Cardioprotective Effect in \u03b2-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation"],"prefix":"10.3390","volume":"14","author":[{"given":"Sumit","family":"Rathod","sequence":"first","affiliation":[{"name":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogeeta","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulla","family":"Sherikar","sequence":"additional","affiliation":[{"name":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik T.","family":"Nakhate","sequence":"additional","affiliation":[{"name":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8401-1978","authenticated-orcid":false,"given":"Chandragouda R.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-7372","authenticated-orcid":false,"given":"M. F.","family":"Nagoor Meeran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-2966","authenticated-orcid":false,"given":"Shreesh","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"},{"name":"Zayed Bin Sultan Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-7049","authenticated-orcid":false,"given":"Sameer N.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Shri Vile Parle Kelavani Mandal\u2019s Institute of Pharmacy, Dhule 424001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","first-page":"2083","article-title":"Epidemiology of Myocardial Infarction","volume":"54","author":"Jayaraj","year":"2018","journal-title":"Minerva Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.biochi.2012.01.015","article-title":"Effect of ursolic acid treatment on apoptosis and DNA damage in isoproterenol-induced myocardial infarction","volume":"94","author":"Radhiga","year":"2012","journal-title":"Biochimie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S2221-6189(14)60051-2","article-title":"Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats","volume":"3","author":"Saxena","year":"2014","journal-title":"J. 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