{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:44:53Z","timestamp":1781005493450,"version":"3.54.1"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Hass Avocado Board","award":["T32 HL079891\u221211"],"award-info":[{"award-number":["T32 HL079891\u221211"]}]},{"name":"The Hass Avocado Board","award":["T32 DK007703\u221226"],"award-info":[{"award-number":["T32 DK007703\u221226"]}]},{"name":"Scientific Councils of the American Heart Association","award":["T32 HL079891\u221211"],"award-info":[{"award-number":["T32 HL079891\u221211"]}]},{"name":"Scientific Councils of the American Heart Association","award":["T32 DK007703\u221226"],"award-info":[{"award-number":["T32 DK007703\u221226"]}]},{"name":"National Heart, Lung, and Blood Institute","award":["T32 HL079891\u221211"],"award-info":[{"award-number":["T32 HL079891\u221211"]}]},{"name":"National Heart, Lung, and Blood Institute","award":["T32 DK007703\u221226"],"award-info":[{"award-number":["T32 DK007703\u221226"]}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["T32 HL079891\u221211"],"award-info":[{"award-number":["T32 HL079891\u221211"]}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["T32 DK007703\u221226"],"award-info":[{"award-number":["T32 DK007703\u221226"]}]},{"name":"Harvard Chan Yerby Fellowship at Harvard T.H. Chan School of Public Health","award":["T32 HL079891\u221211"],"award-info":[{"award-number":["T32 HL079891\u221211"]}]},{"name":"Harvard Chan Yerby Fellowship at Harvard T.H. Chan School of Public Health","award":["T32 DK007703\u221226"],"award-info":[{"award-number":["T32 DK007703\u221226"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a public health concern and Hispanic\/Latinos are disproportionately affected. There is evidence for favorable effects of dietary intake of monounsaturated fatty acids (MUFA) on NAFLD, yet studies examining avocados as a source of MUFA on hepatic function have not been assessed. We investigated the effects of low (3) vs. high (14) avocado allotment on biomarkers of NAFLD, oxidative stress, and NAFLD fibrosis score in a sample of Hispanic\/Latino adults. Primary outcomes include hepatic function biomarkers [gamma glutamyltransferase (GGT), high-sensitivity c-reactive protein (hsCRP), and NAFLD fibrosis score]. Unpaired, two-sided t-tests were used to assess mean differences between intervention groups at 6 months and analysis of covariance models were used to adjust for diet quality and change in avocado intake from baseline to 6 months. Multivariable linear regression models evaluated the baseline and post-intervention association between avocado allotment group and outcomes, adjusting for covariates and stratifying by prediabetes status. No statistically significant differences were observed between low and high avocado allotment groups in liver enzymes, GGT, hsCRP or NAFLD fibrosis score. Findings persisted after stratifying by prediabetes status. Varied intake of avocados resulted in no effects on biomarkers of NAFLD in healthy adults, free of severe chronic disease.<\/jats:p>","DOI":"10.3390\/nu14132744","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:21:50Z","timestamp":1656634910000},"page":"2744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in Biomarkers of Non-Alcoholic Fatty Liver Disease (NAFLD) upon Access to Avocados in Hispanic\/Latino Adults: Secondary Data Analysis of a Cluster Randomized Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-9506","authenticated-orcid":false,"given":"Lorena S.","family":"Pacheco","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA"},{"name":"The Herbert Wertheim School of Public Health and Human Longevity Science, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA"},{"name":"School of Public Health, San Diego State University, Hardy Tower Room 119, 5500 Campanile Drive, San Diego, CA 92182, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Bradley","sequence":"additional","affiliation":[{"name":"The Herbert Wertheim School of Public Health and Human Longevity Science, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A. M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The Herbert Wertheim School of Public Health and Human Longevity Science, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, The School of Medicine, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases (2019, July 20). 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