{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:30:01Z","timestamp":1784802601971,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["ID1099480"],"award-info":[{"award-number":["ID1099480"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["ID1144544"],"award-info":[{"award-number":["ID1144544"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC Medical Research Futures Fund (MRFF) Career Development Fellowship","doi-asserted-by":"publisher","award":["ID1099480"],"award-info":[{"award-number":["ID1099480"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC Medical Research Futures Fund (MRFF) Career Development Fellowship","doi-asserted-by":"publisher","award":["ID1144544"],"award-info":[{"award-number":["ID1144544"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nova Institute for Health","award":["ID1099480"],"award-info":[{"award-number":["ID1099480"]}]},{"name":"Nova Institute for Health","award":["ID1144544"],"award-info":[{"award-number":["ID1144544"]}]},{"name":"Telethon-Perth Children\u2019s Hospital Research Fund","award":["ID1099480"],"award-info":[{"award-number":["ID1099480"]}]},{"name":"Telethon-Perth Children\u2019s Hospital Research Fund","award":["ID1144544"],"award-info":[{"award-number":["ID1144544"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Infant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects. In pregnancy, the immunomodulatory effects of prebiotics may also have benefits for the developing fetal immune system, and provide a potential dietary strategy to reduce the risk of allergic disease. Here, we present the study protocol for a double-blinded, randomised controlled trial investigating the effects of maternal prebiotics supplementation on child allergic disease outcomes. Eligible pregnant women have infants with a first-degree relative with a history of medically diagnosed allergic disease. Consented women are randomised to consume either prebiotics (galacto-oligosaccharides and fructo-oligosaccharides) or placebo (maltodextrin) powder daily from 18\u201320 weeks\u2019 gestation to six months\u2019 post-partum. The target sample size is 652 women. The primary outcome is infant medically diagnosed eczema; secondary outcomes include allergen sensitisation, food allergies and recurrent wheeze. Breast milk, stool and blood samples are collected at multiple timepoints for further analysis.<\/jats:p>","DOI":"10.3390\/nu14132753","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:59:18Z","timestamp":1656968358000},"page":"2753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months\u2019 Post-Partum on Child Allergic Disease Outcomes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2498-8343","authenticated-orcid":false,"given":"Debra J.","family":"Palmer","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia"},{"name":"School of Medicine, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Keelan","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Western Australia, Crawley, WA 6009, Australia"},{"name":"School of Biomedical Sciences, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9182","authenticated-orcid":false,"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CS Utrecht, The Netherlands"},{"name":"Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Simmer","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Western Australia, Crawley, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Jenmalm","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Link\u00f6ping University, 581 83 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravisha","family":"Srinivasjois","sequence":"additional","affiliation":[{"name":"Joondalup Health Campus, Joondalup, WA 6027, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Silva","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia"},{"name":"School of Medicine, The University of Western Australia, Crawley, WA 6009, Australia"},{"name":"Joondalup Health Campus, Joondalup, WA 6027, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-8590","authenticated-orcid":false,"given":"Susan L.","family":"Prescott","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, The University of Western Australia, Nedlands, WA 6009, Australia"},{"name":"School of Medicine, The University of Western Australia, Crawley, WA 6009, Australia"},{"name":"Department of Immunology and Dermatology, Perth Children\u2019s Hospital, Nedlands, WA 6009, Australia"},{"name":"Nova Institute for Health, Baltimore, MD 21231, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2011.01.039","article-title":"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants","volume":"127","author":"Osborne","year":"2011","journal-title":"J. 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