{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:55Z","timestamp":1790957695722,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Special Funds of Basic Research of Central Public Welfare Institute","award":["ZX1908"],"award-info":[{"award-number":["ZX1908"]}]},{"name":"the Special Funds of Basic Research of Central Public Welfare Institute","award":["31901698"],"award-info":[{"award-number":["31901698"]}]},{"name":"the Special Funds of Basic Research of Central Public Welfare Institute","award":["2019QNRC001"],"award-info":[{"award-number":["2019QNRC001"]}]},{"name":"National Natural Science Foundation of China","award":["ZX1908"],"award-info":[{"award-number":["ZX1908"]}]},{"name":"National Natural Science Foundation of China","award":["31901698"],"award-info":[{"award-number":["31901698"]}]},{"name":"National Natural Science Foundation of China","award":["2019QNRC001"],"award-info":[{"award-number":["2019QNRC001"]}]},{"name":"the China Association for Science and Technology","award":["ZX1908"],"award-info":[{"award-number":["ZX1908"]}]},{"name":"the China Association for Science and Technology","award":["31901698"],"award-info":[{"award-number":["31901698"]}]},{"name":"the China Association for Science and Technology","award":["2019QNRC001"],"award-info":[{"award-number":["2019QNRC001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Coarse cereals rich in polyphenols, dietary fiber, and other functional components exert multiple health benefits. We investigated the effects of cooked oats, tartary buckwheat, and foxtail millet on lipid profile, oxido-inflammatory responses, gut microbiota, and colonic short-chain fatty acids composition in high-fat diet (HFD) fed rats. Rats were fed with a basal diet, HFD, oats diet (22% oat in HFD), tartary buckwheat diet (22% tartary buckwheat in HFD), and foxtail millet diet (22% foxtail millet in HFD) for 12 weeks. Results demonstrated that oats and tartary buckwheat attenuated oxidative stress and inflammatory responses in serum, and significantly increased the relative abundance of Lactobacillus and Romboutsia in colonic digesta. Spearman\u2019s correlation analysis revealed that the changed bacteria were strongly correlated with oxidative stress and inflammation-related parameters. The concentration of the butyrate level was elevated by 2.16-fold after oats supplementation. In addition, oats and tartary buckwheat significantly downregulated the expression of sterol regulatory element-binding protein 2 and peroxisome proliferator-activated receptors \u03b3 in liver tissue. In summary, our results suggested that oats and tartary buckwheat could modulate gut microbiota composition, improve lipid metabolism, and decrease oxidative stress and inflammatory responses in HFD fed rats. The present work could provide scientific evidence for developing coarse cereals-based functional food for preventing hyperlipidemia.<\/jats:p>","DOI":"10.3390\/nu14132760","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:59:18Z","timestamp":1656968358000},"page":"2760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0123-228X","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Qi","sequence":"additional","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-4659","authenticated-orcid":false,"given":"Xiaoxuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Song","sequence":"additional","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Pang","sequence":"additional","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Peng","sequence":"additional","affiliation":[{"name":"Academy of National Food and Strategic Reserves Administration, Beijing 100037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S2213-8587(21)00118-2","article-title":"Obesity in China 3 Health policy and public health implications of obesity in China","volume":"9","author":"Wang","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110971","DOI":"10.1016\/j.foodres.2022.110971","article-title":"The gut microbiota-brain axis: Role of the gut microbial metabolites of dietary food in obesity","volume":"153","author":"Song","year":"2022","journal-title":"Food Res. 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