{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:14:06Z","timestamp":1761596046449,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["4774\/B\/P01\/2009\/37"],"award-info":[{"award-number":["4774\/B\/P01\/2009\/37"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Excessive adipose tissue in the body may lead to adverse health effects, carbohydrate and lipid metabolism disorders, and cardiovascular diseases. The aim of this study was to analyze the effect of a standardized high-fat meal (HF) on changes in energy expenditure and changes in the oxidation of energy substrates as well as the concentration of glucose, insulin, triglycerides and homocysteine in blood serum in relation to a standardized high-carbohydrate (non-fat, HC) meal in men with different nutritional status. In this study, 26 men (aged 19\u201360) without carbohydrate disorders (study group GS = 13 overweight\/obese; control group GC = 13 normal body weight) were examined. It was observed that following a high-fat or high-carbohydrate meal, men with excessive body weight metabolized the main nutrients differently than men with normal body weight, and postprandial insulin secretion was also different (even without any significant differences in glucose concentrations). Overweight\/obesity, which is in itself a risk factor for cardiovascular disease, contributes to an increase in the concentration of other risk factors, such as the concentration of homocysteine and triglycerides, which is referred to as cardiometabolic risk. Consumption of a high-fat meal increased the number of potential risk factors for cardiovascular disease (homocysteine and triglycerides) compared to a high-carbohydrate meal.<\/jats:p>","DOI":"10.3390\/nu14142876","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:12:40Z","timestamp":1657757560000},"page":"2876","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Fat or High-Carbohydrate Meal\u2014Does It Affect the Metabolism of Men with Excess Body Weight?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-1817","authenticated-orcid":false,"given":"Lucyna","family":"Ostrowska","sequence":"first","affiliation":[{"name":"Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-951X","authenticated-orcid":false,"given":"Joanna","family":"Smarkusz-Zarzecka","sequence":"additional","affiliation":[{"name":"Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Muszy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8805-0744","authenticated-orcid":false,"given":"Edyta","family":"Adamska-Patruno","sequence":"additional","affiliation":[{"name":"Clinical Research Support Centre, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"G\u00f3rska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-4978","authenticated-orcid":false,"given":"Adam","family":"Kr\u0119towski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref_1","unstructured":"(2022, June 07). World Health Organization. Obesity and Overweight. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_2","first-page":"2745","article-title":"Oty\u0142o\u015b\u0107","volume":"wyd.12","author":"Szczeklik","year":"2021","journal-title":"Interna Szczeklika"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.numecd.2018.06.015","article-title":"Prevalence and cardiometabolic risks of normal weight obesity in Chinese population: A nationwide study","volume":"28","author":"Jia","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.amjcard.2007.03.107","article-title":"Postprandial hyperglycemia\/hyperlipidemina (postprandial dysmetabolism) is a cardiovascular risk factor","volume":"100","author":"Bell","year":"2007","journal-title":"Am. J. Cardio"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/sj.ejcn.1602749","article-title":"Methodology for studying postprandial lipid metabolism","volume":"61","author":"Lairon","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.5603\/KP.2016.0120","article-title":"Wytyczne ESC Dotycz\u0105ce Prewencji Chor\u00f3b Uk\u0142adu Sercowo-Naczyniowego W Praktyce Klinicznej w 2016 roku. (S.W.G.R.E.T.K.) s","volume":"74","author":"Piepoli","year":"2016","journal-title":"Kardiol Pol."},{"key":"ref_7","first-page":"56","article-title":"The impact of a low-carbohydrate diet on human health","volume":"63","year":"2017","journal-title":"Pomeranian J. Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.numecd.2013.12.008","article-title":"The low-carbohydrate diet and cardiovascular risk factors: Evidence from epidemiologic studiem","volume":"24","author":"Hu","year":"2014","journal-title":"Nutr. Metab. Cardiovasc Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4158\/EP.14.1.112","article-title":"Postprandial dysmetabolism: The missing link between diabetes and cardiovascular events?","volume":"14","author":"Bell","year":"2008","journal-title":"Endocr. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.14310\/horm.2002.1697","article-title":"Postprandial dysmetabolism: Too early or too late?","volume":"15","author":"Pappas","year":"2016","journal-title":"Hormones"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.yfrne.2009.03.004","article-title":"Sexual differences in the control of energy homeostasis","volume":"30","author":"Shi","year":"2009","journal-title":"Front. Neuroendocr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1139\/o11-067","article-title":"Sex differences in lipid metabolism and metabolic disease risk","volume":"90","author":"Sugiyama","year":"2012","journal-title":"Biochem. Cell Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.2337\/diacare.28.11.2745","article-title":"Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S","volume":"28","author":"Ford","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ejcn.2016.220","article-title":"Indirect calorimetry: An indispensable tool to understand and predict obesity","volume":"71","author":"Lam","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Adamska-Patruno, E., Ostrowska, L., Golonko, A., Pietraszewska, B., Goscik, J., Kretowski, A., and Gorska, M. (2018). Evaluation of Energy Expenditure and Oxidation of Energy Substrates in Adult Males after Intake of Meals with Varying Fat and Carbohydrate Content. Nutrients, 10.","DOI":"10.3390\/nu10050627"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12986-017-0175-5","article-title":"Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults","volume":"14","author":"Urbain","year":"2017","journal-title":"Nutr. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ajcn\/77.1.91","article-title":"Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake","volume":"77","author":"Raben","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000317343","article-title":"Metabolic and Appetite Hormone Responses of Hyperinsulinemic Normoglycemic Males to Meals with Varied Macronutrient Compositions","volume":"57","author":"Hwalla","year":"2010","journal-title":"Ann. Nutr. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2796.2009.02174.x","article-title":"Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients","volume":"267","author":"Wycherley","year":"2010","journal-title":"J. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1079\/BJN2001365","article-title":"Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat","volume":"86","author":"Bots","year":"2001","journal-title":"Br. J. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1017\/S0007114517002902","article-title":"Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: A systematic review and meta-analysis of randomised controlled trials","volume":"119","author":"Lu","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_22","first-page":"289","article-title":"Hyperhomocysteinemia: A real risk factor for atheroclerosis?","volume":"9","author":"Grabysa","year":"2007","journal-title":"Pol. Prz. Kardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1177\/2047487315623884","article-title":"Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysis","volume":"23","author":"Eckel","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_24","first-page":"E494","article-title":"Regulation of glucose metabolism in nondiabetic, metabolically obese normal-weight Asians","volume":"314","author":"Ding","year":"2018","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.nutres.2008.09.011","article-title":"Long-term consumption of a carbohydrate-restricted diet does not induce deleterious metabolic effects","volume":"28","author":"Grieb","year":"2008","journal-title":"Nutr. 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