{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:51:14Z","timestamp":1793029874290,"version":"4.5.0"},"reference-count":90,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Perfood GmbH, manufacturer of the DTx sinCephalea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Migraine is a headache disorder associated with a high socioeconomic burden. The digital therapeutic sinCephalea provides an individualized low-glycemic diet based on continuous glucose measurement and is intended to provide a non-pharmacological migraine prophylaxis. We performed two prospective studies with migraine patients who used sinCephalea over a period of 16 weeks. The patients used a headache diary and recorded their migraine-related daily life impairments using the assessment tools HIT-6 and MIDAS for a pre versus post comparison. In addition, continuous glucose data of patients were compared to healthy controls. In both studies, patients reported a reduction of headache and migraine days as well as reductions in HIT-6 and MIDAS scores. More specifically, migraine days decreased by 2.40 days (95% CI [\u22123.37; \u22121.42]), HIT-6 improved by 3.17 points (95% CI [\u22124.63; \u22121.70]) and MIDAS by 13.45 points (95% CI [\u221222.01; \u22124.89]). Glucose data suggest that migraine patients have slightly increased mean glucose values compared to healthy controls, but drop into a glucose range that is below one\u2019s individual standard range before a migraine attack. In conclusion, sinCephalea is a non-pharmacological, digital migraine prophylaxis that induces a therapeutic effect within the range of pharmacological interventions.<\/jats:p>","DOI":"10.3390\/nu14142927","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T01:53:22Z","timestamp":1658109202000},"page":"2927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Digital Therapeutic Allowing a Personalized Low-Glycemic Nutrition for the Prophylaxis of Migraine: Real World Data from Two Prospective Studies"],"prefix":"10.3390","volume":"14","author":[{"given":"Vivian Valeska","family":"Lelleck","sequence":"first","affiliation":[{"name":"Institute of Nutritional Medicine, University Hospital of Schleswig-Holstein, Campus L\u00fcbeck & University of L\u00fcbeck, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Schulz","sequence":"additional","affiliation":[{"name":"Perfood GmbH, Research & Development, Am Spargelhof 2, 23554 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Witt","sequence":"additional","affiliation":[{"name":"Perfood GmbH, Research & Development, Am Spargelhof 2, 23554 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Perfood GmbH, Research & Development, Am Spargelhof 2, 23554 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Klein","sequence":"additional","affiliation":[{"name":"Perfood GmbH, Research & Development, Am Spargelhof 2, 23554 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Gendolla","sequence":"additional","affiliation":[{"name":"Medical Practice for Neurology and Pain Therapy Essen, Am Alfredusbad 2, 45133 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-3244","authenticated-orcid":false,"given":"Stefan","family":"Evers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of M\u00fcnster, Domagkstr. 3, 48149 M\u00fcnster, Germany"},{"name":"Department of Neurology, Krankenhaus Lindenbrunn, 31863 Coppenbr\u00fcgge, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charly","family":"Gaul","sequence":"additional","affiliation":[{"name":"Headache Center Frankfurt, Dalbergstr. 2a, 65929 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamant","family":"Tha\u00e7i","sequence":"additional","affiliation":[{"name":"Institute and Comprehensive Center for Inflammation Medicine, University of L\u00fcbeck, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sina","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University Hospital of Schleswig-Holstein, Campus L\u00fcbeck & University of L\u00fcbeck, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Medicine, University Hospital of Schleswig-Holstein, Campus L\u00fcbeck & University of L\u00fcbeck, Ratzeburger Allee 160, 23538 L\u00fcbeck, Germany"},{"name":"Perfood GmbH, Research & Development, Am Spargelhof 2, 23554 L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,17]]},"reference":[{"key":"ref_1","unstructured":"(2018). 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