{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:55:27Z","timestamp":1791053727646,"version":"4.1.0"},"reference-count":205,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Magnesium (Mg) is an essential divalent cation involved in various enzymatic reactions that regulate vital biological functions. The main goal was to evaluate Mg status and its association with nutritional indicators in 78 children and adolescents with chronic diseases. We assessed anthropometric, biochemical, diet, body composition, and bone densitometry valuations. Serum Mg and Ca levels were determined using the standardized method and diet calcium (Ca) and Mg consumption by a prospective 72 h diet survey. Mean serum Ca (9.9 mg\/dL), Mg (2.08 mg\/dL) dietary Ca (102% DRI: Dietary Reference Intake), and Mg intake (105% DRI) were normal. A total of 45% had hypomagnesemia, 12% had hypermagnesemia, and 26% and 24% had inadequate and high Mg intake, respectively. Only 6% of patients had poor Mg intake and hypomagnesemia, and 54% and 90% of our series had an elevated serum Ca\/Mg ratio &gt; 4.70 (mean 4.79) and a low Ca\/Mg intake ratio &lt; 1.70 (mean 1.06), respectively. Both Ca\/Mg ratios were linked with the risk of developing other chronic conditions such as cardiovascular disease, type 2 diabetes, syndrome metabolic, and even several cancers. Therefore, 79% of children and adolescents with chronic diseases were at elevated risk of having abnormal Mg status and developing other chronic illnesses.<\/jats:p>","DOI":"10.3390\/nu14142941","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:19:21Z","timestamp":1658189961000},"page":"2941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Magnesium Status and Ca\/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-3752","authenticated-orcid":false,"given":"Marlene Fabiola","family":"Escobedo-Monge","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Valladolid University, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Barrado","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Science Faculty, Campus Miguel Delibes, University of Valladolid, Calle Paseo de Bel\u00e9n, 7, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Parodi-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Science Faculty, Cadiz University, Paseo de Carlos III, 28, 11003 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6318-7333","authenticated-orcid":false,"given":"Mar\u00eda Antonieta","family":"Escobedo-Monge","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Ba\u00f1uelos sn, 09001 Burgos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"Torres-Hinojal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Valladolid University, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Marug\u00e1n-Miguelsanz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Valladolid University, Avenida Ram\u00f3n y Cajal, 7, 47005 Valladolid, Spain"},{"name":"Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1377\/hlthaff.2014.0832","article-title":"The rise in chronic conditions among infants, children, and youth can be met with continued health system innovations","volume":"33","author":"Perrin","year":"2014","journal-title":"Health Aff."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00431-008-0697-y","article-title":"Dutch National Consensus Committee Chronic Diseases and Health Conditions in Childhood. 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