{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:54:09Z","timestamp":1761598449323,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"a Bonus Qualit\u00e9 Recherche bursary of Sorbonne Paris Nord University (formerly Paris 13 University)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Long-chain omega-3 and omega-6 fatty acids (n-3, n-6 FAs) may modulate inflammation and affect the risk of developing rheumatoid arthritis (RA). However, whether n-3\/n-6 FA status affects RA after disease onset is unknown. This study aimed to assess whether FA profiles are independently associated with disease activity in a large prospective cohort of patients with early RA. Methods: Baseline serum FAs were quantified in 669 patients in the ESPOIR cohort. Principal component analysis identified three serum FA patterns that were rich in n-7\u20139, n-3 and n-6 FAs (patterns \u03c97\u20139, \u03c93 and \u03c96), respectively. The association of pattern tertiles with baseline variables and 6-month disease activity was tested using multivariable logistic regression. Results: Pattern \u03c93 was associated with low baseline and pattern \u03c96 with high baseline C-reactive protein level and disease activity. Both patterns \u03c93 and \u03c96 were associated with reduced odds of active disease after 6 months of follow-up (pattern \u03c93: odds ratio, tertile three vs. one, 0.49 [95% CI 0.25 to 0.97] and pattern \u03c96: 0.51 [0.28 to 0.95]; p = 0.04 and 0.03, respectively). Conclusions: In a cohort of early RA patients, a serum lipid profile rich in n-3 FAs was independently associated with persistently reduced disease activity between baseline and 6-month follow-up. An n-6 FA profile was also associated with lower 6-month disease activity.<\/jats:p>","DOI":"10.3390\/nu14142947","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:28:25Z","timestamp":1658219305000},"page":"2947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort"],"prefix":"10.3390","volume":"14","author":[{"given":"Johanna","family":"Sigaux","sequence":"first","affiliation":[{"name":"Inserm U1125, Universit\u00e9 Sorbonne Paris Nord, Li2P, 93000 Bobigny, France"},{"name":"H\u00f4pital Avicenne Service de Rhumatologie, GHU-PSSD, Assistance Publique-H\u00f4pitaux de Paris, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-487X","authenticated-orcid":false,"given":"Alice","family":"Bellicha","sequence":"additional","affiliation":[{"name":"\u00c9quipe de Recherche en \u00c9pid\u00e9miologie Nutritionnelle (EREN)\u2014Inserm U1153, Inrae U1125, Cnam, Centre de Recherche Epid\u00e9miologie et Statistiques (CRESS), Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Buscail","sequence":"additional","affiliation":[{"name":"\u00c9quipe de Recherche en \u00c9pid\u00e9miologie Nutritionnelle (EREN)\u2014Inserm U1153, Inrae U1125, Cnam, Centre de Recherche Epid\u00e9miologie et Statistiques (CRESS), Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Julia","sequence":"additional","affiliation":[{"name":"\u00c9quipe de Recherche en \u00c9pid\u00e9miologie Nutritionnelle (EREN)\u2014Inserm U1153, Inrae U1125, Cnam, Centre de Recherche Epid\u00e9miologie et Statistiques (CRESS), Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"},{"name":"Public Health Department, GHU-PSSD, Assistance Publique-H\u00f4pitaux de Paris (APHP), 75004 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9-Marc","family":"Flipo","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Universit\u00e9 de Lille, CHU de Lille, 59037 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Cantagrel","sequence":"additional","affiliation":[{"name":"Centre de Rhumatologie, CHU de Toulouse, 31059 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Laporte","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie-Pharmacologie-Toxicologie, CHU de Grenoble, 38700 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Beal","sequence":"additional","affiliation":[{"name":"H\u00f4pital Avicenne Service de Rhumatologie, GHU-PSSD, Assistance Publique-H\u00f4pitaux de Paris, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Christophe","family":"Boissier","sequence":"additional","affiliation":[{"name":"Inserm U1125, Universit\u00e9 Sorbonne Paris Nord, Li2P, 93000 Bobigny, France"},{"name":"H\u00f4pital Avicenne Service de Rhumatologie, GHU-PSSD, Assistance Publique-H\u00f4pitaux de Paris, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Semerano","sequence":"additional","affiliation":[{"name":"Inserm U1125, Universit\u00e9 Sorbonne Paris Nord, Li2P, 93000 Bobigny, France"},{"name":"H\u00f4pital Avicenne Service de Rhumatologie, GHU-PSSD, Assistance Publique-H\u00f4pitaux de Paris, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jbspin.2019.11.009","article-title":"Origins of rheumatoid arthritis","volume":"87","author":"Boissier","year":"2020","journal-title":"Joint Bone Spine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrrheum.2016.52","article-title":"Family history of rheumatoid arthritis: An old concept with new developments","volume":"12","author":"Frisell","year":"2016","journal-title":"Nat. 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