{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:12Z","timestamp":1790614692613,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Pierre et Jeanne Spiegel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Despite significant improvements in COVID-19 therapy, many patients still present with persistent symptoms and quality-of-life alterations. The aim of this study was to simultaneously investigate the long-term evolution of autonomy, malnutrition and long-lasting symptoms in people infected with COVID-19 and hospitalized in the ICU. Method: Patients\u2019 clinical characteristics; extent of their loss of autonomy based on \u201cAutonomie G\u00e9rontologie Groupes Iso-Ressources\u201d (AG-GIR) classification; nutritional status while following the French and Global Leadership Initiative on Malnutrition (GLIM) recommendations; and symptom evolutions before infection, during hospitalization and rehabilitation, and up to 6 months after returning home were determined in thirty-seven patients. Results: Prior to a COVID-19 infection, all patients were autonomous, but upon admission to the rehabilitation center (CRM), 39% of them became highly dependent. After discharge from the center and 6 months after returning home, only 6 and 3%, respectively, still required considerable assistance. Of these thirty-seven patients, 11% were moderately malnourished and 81% presented with severe malnutrition, with a significant correlation being observed between malnutrition and autonomy (p &lt; 0.05). Except for fatigue, which persisted in 70% of the patients 6 months after discharge from rehabilitation, all other symptoms decreased significantly. Conclusions: This study shows a striking decrease in autonomy associated with malnutrition after hospitalization for a COVID-19 infection and a clear beneficial effect from personalized rehabilitation. However, although almost all patients regained autonomy 6 months after returning home, they often still suffer from fatigue. Patient compliance with their nutritional recommendations deserves further improvement, preferably through personalized and persistent follow-up with the patient.<\/jats:p>","DOI":"10.3390\/nu14153027","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"3027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Rehabilitation on Long-COVID-19 Patient\u2019s Autonomy, Symptoms and Nutritional Observance"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-9133","authenticated-orcid":false,"given":"Jeyniver","family":"Ghanem","sequence":"first","affiliation":[{"name":"Translational Medicine Federation of Strasbourg (FMTS), Team 3072 \u201cMitochondria, Oxidative Stress and Muscle Protection\u201d, Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France"},{"name":"Institut IRIMAS (7499), Institut Universitaire de Technologie, Universit\u00e9 de Haute-Alsace, 12 Rue des Fr\u00e8res Lumi\u00e8re, 68093 Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Passadori","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9adaptation de Mulhouse\u2014CRM, 57 Rue Albert Camus, 68200 Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-1921","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Severac","sequence":"additional","affiliation":[{"name":"Groupe M\u00e9thodes en Recherche Clinique, Service de Sant\u00e9 Publique, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dieterlen","sequence":"additional","affiliation":[{"name":"Institut IRIMAS (7499), Institut Universitaire de Technologie, Universit\u00e9 de Haute-Alsace, 12 Rue des Fr\u00e8res Lumi\u00e8re, 68093 Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Geny","sequence":"additional","affiliation":[{"name":"Translational Medicine Federation of Strasbourg (FMTS), Team 3072 \u201cMitochondria, Oxidative Stress and Muscle Protection\u201d, Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France"},{"name":"Physiology and Functional Exploration Service, University Hospital of Strasbourg, 67091 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-7616","authenticated-orcid":false,"given":"Emmanuel","family":"Andr\u00e8s","sequence":"additional","affiliation":[{"name":"Translational Medicine Federation of Strasbourg (FMTS), Team 3072 \u201cMitochondria, Oxidative Stress and Muscle Protection\u201d, Faculty of Medicine, University of Strasbourg, 67000 Strasbourg, France"},{"name":"Service de M\u00e9decine Interne, Diab\u00e8te et Maladies M\u00e9taboliques, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"ref_1","unstructured":"American Hospital Association (2022, April 06). 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