{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:56Z","timestamp":1787029196409,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad de Guadalajara","award":["511-6\/18-9169"],"award-info":[{"award-number":["511-6\/18-9169"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In patients with head and neck cancer, malnutrition is common. Most cases are treated by chemo-radiotherapy and surgery, with adverse effects on the aerodigestive area. Clinical and biochemical characteristics, health-related quality of life, survival, and risk of death were studied. The selected subjects were divided into normal- and low-phase-angle (PA) groups and followed up for at least two years. Mean ages were 67.2 and 59.3 years for low and normal PA, respectively. Patients with PA &lt; 4.42\u00b0 had significant differences in age, anthropometric and biochemical indicators of malnutrition, and inflammatory status compared to patients with PA &gt; 4.42\u00b0. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. Median survival was 19.8 months for those with PA &lt; 4.42\u00b0 versus 34.4 months for those with PA &gt; 4.42\u00b0 (p &lt; 0.001).The relative risk of death was related to low PA (2.6; p &lt; 0.001). The percentage of living patients (41.7%) is almost the same as the percentage of deceased subjects (43.1%; p = 0.002), with high death rates in patients with PA &lt; 4.42\u00b0. Phase angle was the most crucial predictor of survival and a risk factor for death in the studied cases.<\/jats:p>","DOI":"10.3390\/nu14153030","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"3030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Phase Angle, a Cornerstone of Outcome in Head and Neck Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-6962","authenticated-orcid":false,"given":"Daniel","family":"Sat-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Departamento de Morfolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), 950 Sierra Mojada, Puerta 7, Edificio C, 1er Nivel, Guadalajara 44340, Jalisco, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG CA-874 \u201cCiencias Morfol\u00f3gicas en el Diagn\u00f3stico y Tratamiento de la Enfermedad\u201d, 950 Sierra Mojada, Puerta 7, Edificio C, 1er Nivel, Guadalajara 44340, Jalisco, Mexico"},{"name":"Departamento Cl\u00ednico de Oncolog\u00eda Quir\u00fargica, Divisi\u00f3n de Oncolog\u00eda Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"},{"name":"Comit\u00e9 de Cabeza y Cuello, UMAE, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, 1000 Belisario Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-1362","authenticated-orcid":false,"given":"Brenda-Eugenia","family":"Mart\u00ednez-Herrera","sequence":"additional","affiliation":[{"name":"Hospital General de Zona (HGZ), #02 c\/MF 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Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"},{"name":"Carrera de M\u00e9dico Cirujano y Partero, Coordinaci\u00f3n de Servicio Social, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo-Xicotencatl","family":"Guti\u00e9rrez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02, UMAE Hospital de Especialidades (HE), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 1000 Belisario Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"},{"name":"Carrera de M\u00e9dico Cirujano y Partero, Coordinaci\u00f3n de Servicio Social, Centro Universitario del Sur, Universidad de Guadalajara (UdG), Ciudad Guzm\u00e1n 49000, Jalisco, Mexico"},{"name":"Comisi\u00f3n Interinstitucional de Formaci\u00f3n de Recursos Humanos en Salud, Programa Nacional de Servicio Social en Investigaci\u00f3n 2021, Demarcaci\u00f3n Territorial Miguel Hidalgo 11410, Ciudad de M\u00e9xico, Mexico Programa de Doctorado en Investigaci\u022fn Cl\u00ednica, Coordinaci\u00f3n de Posgrado, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdG), Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-0137","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Trujillo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias M\u00e9dicas, Facultad de Medicina, Universidad de Colima, Colima 28040, Colima, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-5945","authenticated-orcid":false,"given":"Luis-Aar\u00f3n","family":"Quiroga-Morales","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02, UMAE Hospital de 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Divisi\u00f3n de Oncolog\u00eda Hematolog\u00eda, UMAE, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, 1000 Belisario Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Daniel","family":"Flores-Carlos","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Cirug\u00eda General, Servicio de Soporte Nutricio, Divisi\u00f3n de Cirug\u00eda, UMAE, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, 1000 Belisario Dom\u00ednguez, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5138-8063","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Rubio-Jurado","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Divisi\u00f3n de Oncolog\u00eda Hematolog\u00eda, 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