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Shibi tea is a non-Camellia tea prepared from the dried leaves of Adinandra nitida, one of the plants with the greatest flavonoid concentration, with Camellianin A (CA) being the major flavonoid. Shibi tea is extensively used in food and medicine and has been found to provide a variety of health advantages. The benefits of Shibi tea and CA in preventing liver injury have not yet been investigated. The aim of this study was to investigate the hepatoprotective effects of extract of Shibi tea (EST) and CA in mice with carbon tetrachloride (CCl4)-induced acute liver injury. Two different concentrations of EST and CA were given to model mice by gavage for 3 days. Treatment with two concentrations of EST and CA reduced the CCl4-induced elevation of the liver index, liver histopathological injury score, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Western blotting and immunohistochemical analysis demonstrated that EST and CA regulated the oxidative stress signaling pathway protein levels of nuclear factor E2-related factor 2 (Nrf2)\/heme-oxygenase-1 (HO-1), the expression of inflammatory cytokines, the phosphorylated nuclear factor-kappaB p65 (p-NF-\u03baB)\/nuclear factor-kappaB p65 (NF-\u03baB) ratio, the phospho-p44\/42 mitogen-activated protein kinase (p-MAPK), and the apoptosis-related protein levels of BCL2-associated X (Bax)\/B cell leukemia\/lymphoma 2 (Bcl2) in the liver. Taken together, EST and CA can protect against CCl4-induced liver injury by exerting antioxidative stress, anti-inflammation, and anti-apoptosis.<\/jats:p>","DOI":"10.3390\/nu14153037","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"3037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Ruohong","family":"Chen","sequence":"first","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Lian","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Engineering Research Center of Starch and Plant Protein Deep Processing, Ministry of Education, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wen","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Sun","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfei","family":"Lai","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junquan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Society of Plant Protection, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsong","family":"Tang","sequence":"additional","affiliation":[{"name":"Taihongyuan Agriculture Co., Ltd., Xinyi, Maoming 525000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Xuan","sequence":"additional","affiliation":[{"name":"Hospital of South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-1448","authenticated-orcid":false,"given":"Erdong","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Engineering Research Center of Starch and Plant Protein Deep Processing, Ministry of Education, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shili","family":"Sun","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Guangdong Academy of Agricultural Sciences\/Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. 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