{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:32:03Z","timestamp":1762900323425,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: To investigate the impact of nutritional iodine deficiency on thyroid dysfunction (TD) in very low birth weight (VLBW) infants, we analyzed the association between iodine-deficient parenteral nutrition (PN) and TD requiring L-thyroxine (TD-LT4). Methods: Data of VLBW infants were obtained from the Korean Neonatal Network registry. Factors including duration of PN were analyzed according to TD-LT4. Results: TD-LT4 occurred in 490 (8.7%) of 5635 infants, and more frequently occurred in infants requiring PN for \u22654 weeks (10.2%). PN \u2265 4 weeks was one of the risk factors for TD-LT4, with an odds ratio (OR) of 1.346, p = 0.002. However, multivariate analysis showed that TD-LT4 was more of a risk for infants that were small for gestational age (OR 2.987, p &lt; 0.001) and for other neonatal morbidities such as seizures (OR 1.787, p = 0.002) and persistent pulmonary hypertension (OR 1.501, p = 0.039) than PN \u2265 4 weeks (OR 0.791, p = 0.080). Conclusions: Prolonged iodine-deficient PN might affect TD-LT4 in VLBW infants. However, the effect of nutritional iodine deficiency on TD-LT4 risk was less than that of SGA or severe neonatal morbidities in Korean VLBW infants.<\/jats:p>","DOI":"10.3390\/nu14153043","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:17:27Z","timestamp":1658794647000},"page":"3043","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid Dysfunction and the Effect of Iodine-Deficient Parenteral Nutrition in Very Low Birth Weight Infants: A Nationwide Analysis of a Korean Neonatal Network Database"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-067X","authenticated-orcid":false,"given":"JaeYoung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JeongHoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JungSook","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JinSu","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-2246","authenticated-orcid":false,"given":"JiSook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EunSil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaeYoung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Hoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon 51619, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang-Ok","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Gyeongsang National University Hospital, Jinju 52727, Korea"},{"name":"Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju 52828, Korea"},{"name":"Institute of Health Sciences, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.14734\/PN.2019.30.3.160","article-title":"Levothyroxine Sodium Administration and Late Circulatory Collapse in Premature Infants with Thyroid Dysfunction","volume":"30","author":"Do","year":"2019","journal-title":"Perinatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3345\/kjp.2015.58.6.224","article-title":"Thyroid dysfunction in very low birth weight preterm infants","volume":"58","author":"Lee","year":"2015","journal-title":"Korean J. 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