{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:51:15Z","timestamp":1793029875278,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82071226"],"award-info":[{"award-number":["82071226"]}]},{"name":"National Natural Science Foundation of China","award":["81771200"],"award-info":[{"award-number":["81771200"]}]},{"name":"National Natural Science Foundation of China","award":["82171208"],"award-info":[{"award-number":["82171208"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Migraine is related to brain energy deficiency. Niacin is a required coenzyme in mitochondrial energy metabolism. However, the relationship between dietary niacin and migraines remains uncertain. We aimed to evaluate the relationship between dietary niacin and migraine. This study used cross-sectional data from people over 20 years old who took part in the National Health and Nutrition Examination Survey between 1999 and 2004, collecting details on their severe headaches or migraines, dietary niacin intake, and several other essential variables. There were 10,246 participants, with 20.1% (2064\/10,246) who experienced migraines. Compared with individuals with lower niacin consumption Q1 (\u226412.3 mg\/day), the adjusted OR values for dietary niacin intake and migraine in Q2 (12.4\u201318.3 mg\/day), Q3 (18.4\u201326.2 mg\/day), and Q4 (\u226526.3 mg\/day) were 0.83 (95% CI: 0.72\u20130.97, p = 0.019), 0.74 (95% CI: 0.63\u20130.87, p &lt; 0.001), and 0.72 (95% CI: 0.58\u20130.88, p = 0.001), respectively. The association between dietary niacin intake and migraine exhibited an L-shaped curve (nonlinear, p = 0.011). The OR of developing migraine was 0.975 (95% CI: 0.956\u20130.994, p = 0.011) in participants with niacin intake &lt; 21.0 mg\/day. The link between dietary niacin intake and migraine in US adults is L-shaped, with an inflection point of roughly 21.0 mg\/day.<\/jats:p>","DOI":"10.3390\/nu14153052","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:17:27Z","timestamp":1658794647000},"page":"3052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-2938","authenticated-orcid":false,"given":"Huanxian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Health Care 9, The Second Medical Centre, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-2569","authenticated-orcid":false,"given":"Zhao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China"},{"name":"International Headache Center, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China"},{"name":"International Headache Center, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","unstructured":"GBD 2016 Headache Collaborators (2018). Global, regional, and national burden of migraine and tension-type headache, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet. Neurol., 17, 954\u2013976."},{"key":"ref_2","unstructured":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Lond. Engl., 390, 1211\u20131259."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s10194-016-0699-5","article-title":"GBD 2015: Migraine is the third cause of disability in under 50s","volume":"17","author":"Steiner","year":"2016","journal-title":"J. Headache Pain"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gazerani, P. (2020). Migraine and Diet. Nutrients, 12.","DOI":"10.3390\/nu12061658"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/head.12953","article-title":"Diet, and Headache: Part 1","volume":"56","author":"Martin","year":"2016","journal-title":"Headache"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/head.12952","article-title":"Diet, and Headache: Part 2","volume":"56","author":"Martin","year":"2016","journal-title":"Headache"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"653765","DOI":"10.3389\/fnut.2021.653765","article-title":"Dietary Intake of Calcium and Magnesium in Relation to Severe Headache or Migraine","volume":"8","author":"Meng","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"685564","DOI":"10.3389\/fnut.2021.685564","article-title":"Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine","volume":"8","author":"Meng","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.afnr.2017.11.003","article-title":"Niacin","volume":"83","author":"Kirkland","year":"2018","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2020.04.008","article-title":"Niacin Cures Systemic NAD(+) Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy","volume":"31","author":"Pirinen","year":"2020","journal-title":"Cell Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4065\/78.6.770","article-title":"Sustained-release niacin for prevention of migraine headache","volume":"78","author":"Velling","year":"2003","journal-title":"Mayo Clin. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2891-4-3","article-title":"The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): A systematic review of the literature","volume":"4","author":"Prousky","year":"2005","journal-title":"Nutr. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s11064-021-03335-9","article-title":"Brain Energy Deficit as a Source of Oxidative Stress in Migraine: A Molecular Basis for Migraine Susceptibility","volume":"46","author":"Borkum","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_14","unstructured":"National Center for Health Statistics (2022, March 01). NHANES Survey Methods and Analytic Guidelines, Available online: https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/AnalyticGuidelines.aspx."},{"key":"ref_15","first-page":"1","article-title":"National health and nutrition examination survey: Plan and operations, 1999\u20132010","volume":"56","author":"Zipf","year":"2013","journal-title":"Vital Health Stat 1"},{"key":"ref_16","unstructured":"US Department of Health & Human Services (2022, March 01). Office of Extramural Research, Available online: http:\/\/grants.nih.gov\/grants\/policy\/hs\/hs_policies.htm."},{"key":"ref_17","unstructured":"United States Department of Agriculture (USDA); Agriculture Research Service FSRG (2022, March 12). Food and Nutrient Database for Dietary Studies, 5.0, Available online: http:\/\/www.ars.usda.gov\/ba\/bhnrc\/fsrg."},{"key":"ref_18","unstructured":"National Health and Nutrition Examination Survey (NHANES) (2022, March 08). MEC In-Person Dietary Interviewers Procedures Manual, Available online: http:\/\/www.cdc.gov\/nchs\/data\/nhanes\/nhanes_03_04\/dietary_mec.pdf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/head.14065","article-title":"Dietary magnesium and migraine in adults: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2001\u20132004","volume":"61","author":"Slavin","year":"2021","journal-title":"Headache"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/head.12778","article-title":"Association Between Overall and Mentholated Cigarette Smoking With Headache in a Nationally Representative Sample","volume":"56","author":"Gan","year":"2016","journal-title":"Headache"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1526-4610.2009.01459.x","article-title":"Obesity and migraine: The effect of age, gender, and adipose tissue distribution","volume":"50","author":"Peterlin","year":"2010","journal-title":"Headache"},{"key":"ref_22","unstructured":"Agricultural ruralural Research Service, and US Department of Agriculture (2021, March 07). What We Eat in America: Data Tables, Available online: https:\/\/www.ars.usda.gov\/northeast-area\/beltsville-md-bhnrc\/beltsville-human-nutrition-research-center\/food-surveys-research-group\/docs\/wweia-data-tables\/."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"640785","DOI":"10.3389\/fmed.2021.640785","article-title":"Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Med. Lausanne"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1054\/mehy.2000.1117","article-title":"Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid","volume":"56","author":"Gedye","year":"2001","journal-title":"Med. Hypotheses"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1017\/S0007114514003912","article-title":"The Mediterranean diet: Health, science and society","volume":"113","author":"Gerber","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Arab, A., Khorvash, F., Karimi, E., Hadi, A., and Askari, G. (2021). Associations between adherence to Mediterranean dietary pattern and frequency, duration, and severity of migraine headache: A cross-sectional study. Nutr. Neurosci., 1\u201310.","DOI":"10.1080\/1028415X.2021.2009162"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12035-010-8162-0","article-title":"Evolutionary aspects of diet: The omega-6\/omega-3 ratio and the brain","volume":"44","author":"Simopoulos","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.plefa.2018.06.008","article-title":"Long-chain omega-3 fatty acids and headache in the U.S. population","volume":"135","author":"Sanders","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s10194-019-1057-1","article-title":"Association of diet and headache","volume":"20","author":"Ghorbani","year":"2019","journal-title":"J. Headache Pain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/jnnp.52.2.182","article-title":"Plasma serotonin in patients with chronic tension headaches","volume":"52","author":"Anthony","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nm0795-658","article-title":"Brain stem activation in spontaneous human migraine attacks","volume":"1","author":"Weiller","year":"1995","journal-title":"Nat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(00)04250-1","article-title":"Brainstem activation specific to migraine headache","volume":"357","author":"Bahra","year":"2001","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/brain\/aww097","article-title":"The migraine generator revisited: Continuous scanning of the migraine cycle over 30 days and three spontaneous attacks","volume":"139","author":"Schulte","year":"2016","journal-title":"Brain"},{"key":"ref_34","unstructured":"Murray, R.K., Granner, D.K., Mayes, P.A., and Rodwell, V.W. (2000). Harper\u2019s Bio-Chemistry, Appleton and Lange. [25th ed.]."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1212\/WNL.42.6.1209","article-title":"Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura","volume":"42","author":"Barbiroli","year":"1992","journal-title":"Neurology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1007\/s10072-006-0576-0","article-title":"Energy metabolism in migraine","volume":"27","author":"Lodi","year":"2006","journal-title":"Neurol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1046\/j.1468-2982.1994.014003184.x","article-title":"Magnetic resonance spectroscopy studies in migraine","volume":"14","author":"Montagna","year":"1994","journal-title":"Cephalalgia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/1531-8249(200006)47:6<838::AID-ANA25>3.0.CO;2-Z","article-title":"Magnetic resonance spectroscopy of episodic ataxia type 2 and migraine","volume":"47","author":"Montagna","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0404.1992.tb05104.x","article-title":"Brain energy metabolism studied by 31P-MR spectroscopy in a case of migraine with prolonged aura","volume":"86","author":"Sacquegna","year":"1992","journal-title":"Acta Neurol. Scand."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fila, M., Chojnacki, C., Chojnacki, J., and Blasiak, J. (2021). Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine. Nutrients, 13.","DOI":"10.3390\/nu13124433"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/head.12725","article-title":"Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis","volume":"56","author":"Borkum","year":"2016","journal-title":"Headache"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.atherosclerosis.2008.04.044","article-title":"Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells","volume":"202","author":"Ganji","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/head.12150","article-title":"Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study","volume":"53","author":"Buse","year":"2013","journal-title":"Headache"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/aje\/kwr140","article-title":"Evaluation and comparison of food records, recalls, and frequencies for energy and protein assessment by using recovery biomarkers","volume":"174","author":"Prentice","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwg092","article-title":"Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: The OPEN study","volume":"158","author":"Subar","year":"2003","journal-title":"Am. J. Epidemiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/15\/3052\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:56:18Z","timestamp":1760140578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/15\/3052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":45,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["nu14153052"],"URL":"https:\/\/doi.org\/10.3390\/nu14153052","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]}}}