{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:31:23Z","timestamp":1793849483887,"version":"4.6.1"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fresenius Kabi Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: For normo-nourished colorectal cancer patients, the need for immunonutrients after elective surgery is not known. (2) Methods: Multicenter, randomized, double-blind, phase III clinical trial comparing the postoperative diet with 200 mL oligomeric hyperproteic normocaloric (OHN; experimental arm) supplement vs. 200 mL immunonutritional (IN) (active comparator) supplement twice a day for five days in 151 normo-nourished adult colorectal-resection patients following the multimodal rehabilitation ERAS protocol. The proportions of patients with complications (primary outcome) and those who were readmitted, hospitalized for &lt;7 days, had surgical site infections, or died due to surgical complications (secondary outcome) were compared between the two groups until postoperative day 30. Tolerance to both types of supplement and blood parameters was also assessed until day 5. (3) Results: Mean age was 69.2 and 84 (58.7%) were men. Complications were reported in 41 (28.7%) patients and the incidence did not differ between groups (18 (25%) vs. 23 (32.4%) patients with OHN and IN supplement, respectively; p = 0.328). No significant differences were found for the rest of the variables. (4) Conclusions: IN supplement may not be necessary for the postoperative recovery of colorectal cancer patients under the ERAS regimen and with normal nutritional status at the time of surgery.<\/jats:p>","DOI":"10.3390\/nu14153062","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:59:16Z","timestamp":1658897956000},"page":"3062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Postoperative Diet with an Oligomeric Hyperproteic Normocaloric Supplement versus a Supplement with Immunonutrients in Colorectal Cancer Surgery: Results of a Multicenter, Double-Blind, Randomized Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-1314","authenticated-orcid":false,"given":"Jorge Alejandro","family":"Benavides-Buleje","sequence":"first","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Vicente","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-7714","authenticated-orcid":false,"given":"Elena","family":"Ruiz-\u00dacar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Fuenlabrada, 28942 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Solana-Bueno","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital of Sagunto, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Antonio","family":"Parra-Ba\u00f1os","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-5118","authenticated-orcid":false,"given":"Beatriz","family":"Mart\u00ednez-Torres","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Fuenlabrada, 28942 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lozoya-Trujillo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital of Sagunto, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Ruiz-Carmona","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital of Sagunto, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Alarc\u00f3n-Iranzo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital of Sagunto, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rentero-Redondo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-2125","authenticated-orcid":false,"given":"Emilio","family":"Pe\u00f1a-Ros","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Mu\u00f1oz-Camarena","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-2297","authenticated-orcid":false,"given":"Milagros","family":"Carrasco-Prats","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Ram\u00edrez-Faraco","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-4332","authenticated-orcid":false,"given":"Paloma","family":"Portillo-Ortega","sequence":"additional","affiliation":[{"name":"Nutrition Unit, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Albarrac\u00edn-Mar\u00edn-Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of Surgery, Reina Sofia University Hospital, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MCO.0b013e3282f44c41","article-title":"Early Nutrition Support in Critical Care: A European Perspective","volume":"11","author":"Kreymann","year":"2008","journal-title":"Curr. 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