{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:52Z","timestamp":1787029252867,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project of China","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"National Key Research and Development Project of China","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"National Key Research and Development Project of China","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"National Key Research and Development Project of China","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]},{"name":"Research Team Project of Natural Science Foundation of Heilongjiang Province, China","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"Research Team Project of Natural Science Foundation of Heilongjiang Province, China","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"Research Team Project of Natural Science Foundation of Heilongjiang Province, China","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"Research Team Project of Natural Science Foundation of Heilongjiang Province, China","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]},{"name":"The Basic Scientific Research Operating Expenses Projects of Provincial University of Heilongjiang Province","award":["2018YFE0206300"],"award-info":[{"award-number":["2018YFE0206300"]}]},{"name":"The Basic Scientific Research Operating Expenses Projects of Provincial University of Heilongjiang Province","award":["2020YFD1001400"],"award-info":[{"award-number":["2020YFD1001400"]}]},{"name":"The Basic Scientific Research Operating Expenses Projects of Provincial University of Heilongjiang Province","award":["TD2020C003"],"award-info":[{"award-number":["TD2020C003"]}]},{"name":"The Basic Scientific Research Operating Expenses Projects of Provincial University of Heilongjiang Province","award":["ZDZX202106"],"award-info":[{"award-number":["ZDZX202106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Hyperlipidemia with fat accumulation and weight gain causes metabolic diseases and endangers human body health easily which is accompanied by metabolic abnormalities and intestinal flora disorders. In this study, the kidney bean fermented broth (KBF) was used in rats that were fed a high-fat diet to induce hyperlipidemia in order to subsequently analyse the serum metabolomics and gut microbiota modulatoration. The results show that the contents of the total polyphenols and total flavonoids in the KBF were up three and one times, while energy and carbohydrates decreased. In the HFD-induced hyperlipidemic model, body weight, organ weight, and the level of blood lipids (ALT, AST, TG, TC) were lower in rats treated with KBF than in the controls. Metabonomics indicate that there were significant differences in serum metabolomics between the KBF and the HFD. KBF could significantly improve the glycerophospholipids, taurine, and hypotaurine metabolism and amino acid metabolism of hyperlipidemic rats and then improve the symptoms of hypersterol and fat accumulation in rats. The relative abundance of beneficial bacteria increased while pathogenic bacteria decreased after the intervention of KBF. KBF ameliorates dyslipidemia of HFD-induced hyperlipidemic via modulating the blood metabolism and the intestinal microbiota. Collectively, these findings suggest that KBF could be developed as a functional food for anti-hyperlipidemia.<\/jats:p>","DOI":"10.3390\/nu14153202","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T02:12:39Z","timestamp":1659665559000},"page":"3202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition"],"prefix":"10.3390","volume":"14","author":[{"given":"Weiqiao","family":"Pang","sequence":"first","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohang","family":"Zuo","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"National Coarse Cereals Engineering Research Center, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"National Coarse Cereals Engineering Research Center, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.cmet.2021.08.005","article-title":"Global burden of disease study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease","volume":"33","author":"Wang","year":"2021","journal-title":"Cell Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosissup.2016.10.003","article-title":"A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: Review of the clinical evidence","volume":"24","author":"Barrios","year":"2017","journal-title":"Atheroscler. 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