{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:02:18Z","timestamp":1791518538797,"version":"4.3.4"},"reference-count":61,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inserm and Paris Diderot University","award":["ANR-11-LABX-0051"],"award-info":[{"award-number":["ANR-11-LABX-0051"]}]},{"name":"Inserm and Paris Diderot University","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]},{"name":"Laboratory of Excellence","award":["ANR-11-LABX-0051"],"award-info":[{"award-number":["ANR-11-LABX-0051"]}]},{"name":"Laboratory of Excellence","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]},{"name":"Labex GR-Ex","award":["ANR-11-LABX-0051"],"award-info":[{"award-number":["ANR-11-LABX-0051"]}]},{"name":"Labex GR-Ex","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]},{"name":"French National Research Agency","award":["ANR-11-LABX-0051"],"award-info":[{"award-number":["ANR-11-LABX-0051"]}]},{"name":"French National Research Agency","award":["ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR-11-IDEX-0005-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency is a significant comorbidity of heart failure (HF), defined as the inability of the myocardium to provide sufficient blood flow. However, iron deficiency remains insufficiently detected. Iron-deficiency anemia, defined as a decrease in hemoglobin caused by iron deficiency, is a late consequence of iron deficiency, and the symptoms of iron deficiency, which are not specific, are often confused with those of HF or comorbidities. HF patients with iron deficiency are often rehospitalized and present reduced survival. The correction of iron deficiency in HF patients is associated with improved functional capacity, quality of life, and rehospitalization rates. Because of the inflammation associated with chronic HF, which complicates the picture of nutritional deficiency, only the parenteral route can bypass the tissue sequestration of iron and the inhibition of intestinal iron absorption. Given the negative impact of iron deficiency on HF progression, the frequency and financial implications of rehospitalizations due to decompensation episodes, and the efficacy of this supplementation, screening for this frequent comorbidity should be part of routine testing in all HF patients. Indeed, recent European guidelines recommend screening for iron deficiency (serum ferritin and transferrin saturation coefficient) in all patients with suspected HF, regular iron parameters assessment in all patients with HF, and intravenous iron supplementation in symptomatic patients with proven deficiency. We thus aim to summarize all currently available data regarding this common and easily improvable comorbidity.<\/jats:p>","DOI":"10.3390\/nu14153214","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:33:11Z","timestamp":1659997991000},"page":"3214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neglected Comorbidity of Chronic Heart Failure: Iron Deficiency"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-0964","authenticated-orcid":false,"given":"Hana","family":"Manceau","sequence":"first","affiliation":[{"name":"Inflammation Research Center CRI, INSERM UMRs 1149, Universit\u00e9 de Paris, 75018 Paris, France"},{"name":"Departement of Biochemistry, Bichat Hospital, APHP, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-9777","authenticated-orcid":false,"given":"J\u00e9rome","family":"Ausseil","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, CHU Toulouse, Infinity, INSERM UMR 1291, CNRS UMR 5051, Universit\u00e9 Paul Sabatier, CEDEX 3, 31024 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-4730","authenticated-orcid":false,"given":"Damien","family":"Masson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Facult\u00e9 de M\u00e9decine, Nantes University Hospital, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Feugeas","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie H\u00f4pital Jean Minjoz, Universit\u00e9 Bourgogne Franche-Comt\u00e9, INSERM, EFS BFC, UMR1098, Interactions H\u00f4te-Greffon-Tumeur\/Ing\u00e9nierie Cellulaire et G\u00e9nique, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Sablonniere","sequence":"additional","affiliation":[{"name":"Centre de Biologie Pathologie et G\u00e9n\u00e9tique, CHU Lille, JPArc\u2014Centre de Recherche Jean-Pierre AUBERT, Institut de Biochimie et Biologie mol\u00e9culaire, University Lille, Inserm, CHU Lille, UMR-S 1172, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-0814","authenticated-orcid":false,"given":"R\u00e9gis","family":"Guieu","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Assistance Publique des Hopitaux, Center for Cardio-Vascular and Nutrition Research, INSERM, INRAE, Aix-Marseille University, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-2634","authenticated-orcid":false,"given":"Herv\u00e9","family":"Puy","sequence":"additional","affiliation":[{"name":"Inflammation Research Center CRI, INSERM UMRs 1149, Universit\u00e9 de Paris, 75018 Paris, France"},{"name":"Departement of Biochemistry, Bichat Hospital, APHP, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-1243","authenticated-orcid":false,"given":"Katell","family":"Peoc\u2019h","sequence":"additional","affiliation":[{"name":"Inflammation Research Center CRI, INSERM UMRs 1149, Universit\u00e9 de Paris, 75018 Paris, France"},{"name":"Departement of Biochemistry, Bichat Hospital, APHP, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","first-page":"11-024-A-10","article-title":"Insuffisance Cardiaque: Aspects \u00c9pid\u00e9miologiques, Cliniques et Pronostiques","volume":"13","author":"Gibelin","year":"2018","journal-title":"EMC Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ejhf.1494","article-title":"Heart Failure Association of the European Society of Cardiology Practical Guidance on the Use of Natriuretic Peptide Concentrations","volume":"21","author":"Mueller","year":"2019","journal-title":"Eur. 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