{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:57Z","timestamp":1791919077234,"version":"4.3.4"},"reference-count":64,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Group of Guillermina Azucena Bongiovanni","award":["PIP 0239-CONICET"],"award-info":[{"award-number":["PIP 0239-CONICET"]}]},{"name":"Becas de Integraci\u00f3n Regional para ciudadanos de Latinoam\u00e9rica y El Caribe\u2014Convocatoria 2019","award":["PIP 0239-CONICET"],"award-info":[{"award-number":["PIP 0239-CONICET"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Oxidative stress is an imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes. Compounds with antioxidant properties, such as coenzyme Q10 (CoQ10), can reduce cellular imbalance caused by an increase in ROS. CoQ10 participates in modulating redox homeostasis due to its antioxidant activity and its preserving mitochondrial functions. Thus, the present study demonstrated the protective effects of CoQ10 against oxidative stress and cytotoxicity induced by arsenic (As). Antioxidant capacity, formation of hydroperoxides, generation of ROS, and the effect on cellular viability of CoQ10, were investigated to determine the protective effect of CoQ10 against As and pro-oxidant compounds, such as zinc. Cell viability assays showed that CoQ10 is cytoprotective under cellular stress conditions, with potent antioxidant activity, regardless of the concentration tested. Zn, when used at higher concentrations, can increase ROS and show a pro-oxidant effect causing cell damage. The cytotoxic effect observed for As, Zn, or the combination of both could be prevented by CoQ10, without any decrease in its activity at cellular levels when combined with Zn.<\/jats:p>","DOI":"10.3390\/nu14163265","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:46:24Z","timestamp":1660124784000},"page":"3265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-2647","authenticated-orcid":false,"given":"Saulo Victor e","family":"Silva","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, Federal University of the Rio Grande do Norte (UFRN), Natal 59012570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-7110","authenticated-orcid":false,"given":"Mar\u00eda Celeste","family":"Gallia","sequence":"additional","affiliation":[{"name":"Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), School of Agricultural Sciences, Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-7617","authenticated-orcid":false,"given":"Jefferson Rom\u00e1ryo Duarte da","family":"Luz","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Health Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, UFRN, Natal 59012570, Brazil"},{"name":"Organic Chemistry and Biochemistry Laboratory, State University of Amap\u00e1 (UEAP), Macap\u00e1 68900070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-4047","authenticated-orcid":false,"given":"Adriana Augusto de","family":"Rezende","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, Federal University of the Rio Grande do Norte (UFRN), Natal 59012570, Brazil"},{"name":"Post-Graduation Program in Health Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, UFRN, Natal 59012570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-2586","authenticated-orcid":false,"given":"Guillermina Azucena","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN), National Council for Scientific and Technical Research (CONICET), School of Agricultural Sciences, Neuqu\u00e9n 8300, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-1995","authenticated-orcid":false,"given":"Gabriel","family":"Araujo-Silva","sequence":"additional","affiliation":[{"name":"Organic Chemistry and Biochemistry Laboratory, State University of Amap\u00e1 (UEAP), Macap\u00e1 68900070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-0922","authenticated-orcid":false,"given":"Maria das Gra\u00e7as","family":"Almeida","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Pharmaceutical Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, Federal University of the Rio Grande do Norte (UFRN), Natal 59012570, Brazil"},{"name":"Post-Graduation Program in Health Sciences, Multidisciplinary Research Laboratory, Department of Clinical and Toxicological Analysis (DACT), Health Sciences Center, UFRN, Natal 59012570, Brazil"},{"name":"Sciences Center, UFRN, Natal 59012570, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and diseases: Role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol. 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