{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:46:48Z","timestamp":1768312008310,"version":"3.49.0"},"reference-count":145,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The recent outbreak of the novel Coronavirus (SARS-CoV-2 or CoV-2) pandemic in 2019 and the risk of CoV-2 infection during pregnancy led the scientific community to investigate the potential negative effects of Coronavirus infection on pregnancy outcomes and fetal development. In particular, as CoV-2 neurotropism has been demonstrated in adults, recent studies suggested a possible risk of fetal brain damage and fetal brain development impairment, with consequent psychiatric manifestations in offspring of mothers affected by COronaVIrus Disease (COVID) during pregnancy. Through the understanding of CoV-2\u2019s pathogenesis and the pathways responsible for cell damage, along with the available data about neurotropic virus attitudes, different strategies have been suggested to lower the risk of neurologic disease in newborns. In this regard, the role of nutrition in mitigating fetal damages related to oxidative stress and the inflammatory environment during viral infection has been investigated, and arginine, n3PUFA, vitamins B1 and B9, choline, and flavonoids were found to be promising in and out of pregnancy. The aim of this review is to provide an overview of the current knowledge on the mechanism of fetal brain damage and the impact of nutrition in reducing inflammation related to worse neurological outcomes in the context of CoV-2 infections during pregnancy.<\/jats:p>","DOI":"10.3390\/nu14163303","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T03:33:20Z","timestamp":1660534400000},"page":"3303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fetal Brain Damage during Maternal COVID-19: Emerging Hypothesis, Mechanism, and Possible Mitigation through Maternal-Targeted Nutritional Supplementation"],"prefix":"10.3390","volume":"14","author":[{"given":"Chiara","family":"Germano","sequence":"first","affiliation":[{"name":"Department of Maternal, Neonatal and Infant Medicine, University Hospital \u201cDegli Infermi\u201d, 13875 Ponderano, Italy"},{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6868-036X","authenticated-orcid":false,"given":"Alessandro","family":"Messina","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tavella","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Vitale","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Avellis","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Barboni","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Attini","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-3722","authenticated-orcid":false,"given":"Alberto","family":"Revelli","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Zola","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna Hospital, Department of Surgical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-3493","authenticated-orcid":false,"given":"Paolo","family":"Manzoni","sequence":"additional","affiliation":[{"name":"Department of Maternal, Neonatal and Infant Medicine, University Hospital \u201cDegli Infermi\u201d, 13875 Ponderano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Masturzo","sequence":"additional","affiliation":[{"name":"Department of Maternal, Neonatal and Infant Medicine, University Hospital \u201cDegli Infermi\u201d, 13875 Ponderano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100769","DOI":"10.1016\/j.spen.2019.08.005","article-title":"Viral Infections and the Neonatal Brain","volume":"32","year":"2019","journal-title":"Semin. 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