{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:00:30Z","timestamp":1791925230473,"version":"4.3.4"},"reference-count":99,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["FZGW-2020-0001"],"award-info":[{"award-number":["FZGW-2020-0001"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075001X39782002"],"award-info":[{"award-number":["075001X39782002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Obesity is a problem of modern health care that causes the occurrence of many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for the treatment and prevention of obesity are being developed that are based on using probiotics for modulation of the gut microbiota. Our study aimed to evaluate the bacterial composition of the gut of obese patients before and after two weeks of lactic acid bacteria (Lactobacillus acidophilus, Lactiplantibacillus plantarum, Limosilactobacillus fermentum, and Lactobacillus delbrueckii) intake. The results obtained showed an increase in the number of members of the phylum Actinobacteriota in the group taking nutritional supplements, while the number of phylum Bacteroidota decreased in comparison with the control group. There has also been an increase in potentially beneficial groups: Bifidobacterium, Blautia, Eubacterium, Anaerostipes, Lactococcus, Lachnospiraceae ND3007, Streptococcus, Escherichia-Shigella, and Lachnoclostridium. Along with this, a decrease in the genera was demonstrated: Faecalibacterium, Pseudobutyrivibrio, Subdoligranulum, Faecalibacterium, Clostridium sensu stricto 1 and 2, Catenibacterium, Megasphaera, Phascolarctobacterium, and the Oscillospiraceae NK4A214 group, which contribute to the development of various metabolic disorders. Modulation of the gut microbiota by lactic acid bacteria may be one of the ways to treat obesity.<\/jats:p>","DOI":"10.3390\/nu14163384","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T23:28:41Z","timestamp":1660865321000},"page":"3384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["The Effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-0845","authenticated-orcid":false,"given":"Inna","family":"Burakova","sequence":"first","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2076-3868","authenticated-orcid":false,"given":"Mariya","family":"Gryaznova","sequence":"additional","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Syromyatnikov","sequence":"additional","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Chizhkov","sequence":"additional","affiliation":[{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Popov","sequence":"additional","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-8686","authenticated-orcid":false,"given":"Vasily","family":"Popov","sequence":"additional","affiliation":[{"name":"Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000354899","article-title":"The Human Microbiome and Probiotics: Implications for Pediatrics","volume":"63","author":"Versalovic","year":"2013","journal-title":"Ann. Nutr. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global Epidemiology and Pathogenesis","volume":"15","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1097\/j.pbj.0000000000000111","article-title":"Obesity and Gut Microbiome: Review of Potential Role of Probiotics","volume":"6","author":"Barata","year":"2021","journal-title":"Porto Biomed. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jfma.2018.07.009","article-title":"The Gut Microbiome in Obesity","volume":"118","author":"Tseng","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.2005.073817","article-title":"Reduced Diversity of Faecal Microbiota in Crohn\u2019s Disease Revealed by a Metagenomic Approach","volume":"55","author":"Manichanh","year":"2006","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A Core Gut Microbiome in Obese and Lean Twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"ref_7","first-page":"1","article-title":"Composition, Diversity and Abundance of Gut Microbiome in Prediabetes and Type 2 Diabetes","volume":"2","author":"Lambeth","year":"2015","journal-title":"J. Diabetes Obes."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12944-016-0278-4","article-title":"The Role of Gut Microbiota in the Development of Obesity and Diabetes","volume":"15","author":"Baothman","year":"2016","journal-title":"Lipids Health Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/fbe2.12002","article-title":"Advances in the Role and Mechanism of Lactic Acid Bacteria in Treating Obesity","volume":"1","author":"Shen","year":"2022","journal-title":"Food Bioeng."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101724","DOI":"10.1016\/j.fbio.2022.101724","article-title":"Three Lactic Acid Bacteria with Anti-Obesity Properties: In Vitro Screening and Probiotic Assessment","volume":"47","author":"Wei","year":"2022","journal-title":"Food Biosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.3168\/jds.2018-15014","article-title":"Therapeutic Effects of Kefir Grain Lactobacillus-Derived Extracellular Vesicles in Mice with 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Inflammatory Bowel Disease","volume":"101","author":"Seo","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.tifs.2020.02.029","article-title":"Potential Anti-Carcinogenic Effect of Probiotic and Lactic Acid Bacteria in Detoxification of Benzo[a]Pyrene: A Review","volume":"99","author":"Shoukat","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nut.2018.03.005","article-title":"Lactobacillus Paracasei HII01, Xylooligosaccharides, and Synbiotics Reduce Gut Disturbance in Obese Rats","volume":"54","author":"Thiennimitr","year":"2018","journal-title":"Nutrition"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.3382\/ps\/pez166","article-title":"Effects of Dietary Inclusion of Lactobacillus and Inulin on Growth Performance, Gut Microbiota, Nutrient Utilization, and Immune Parameters in Broilers","volume":"98","author":"Wu","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/1574-6968.12293","article-title":"The Life History of Lactobacillus Acidophilus as a Probiotic: A Tale of Revisionary Taxonomy, Misidentification and Commercial Success","volume":"349","author":"Bull","year":"2013","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_16","first-page":"CD003048","article-title":"Probiotics for Treating Acute Infectious Diarrhoea","volume":"2010","author":"Allen","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.nut.2018.07.116","article-title":"Effects of 12-Wk Lactobacillus Plantarum OLL2712 Treatment on Glucose Metabolism and Chronic Inflammation in Prediabetic Individuals: A Single-Arm Pilot Study","volume":"58","author":"Toshimitsu","year":"2019","journal-title":"Nutrition"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Costabile, A., Buttarazzi, I., Kolida, S., Quercia, S., Baldini, J., Swann, J.R., Brigidi, P., and Gibson, G.R. (2017). An in Vivo Assessment of the Cholesterol-Lowering Efficacy of Lactobacillus Plantarum ECGC 13110402 in Normal to Mildly Hypercholesterolaemic Adults. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187964"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1007\/s00253-018-9403-9","article-title":"Immunobiosis and Probiosis: Antimicrobial Activity of Lactic Acid Bacteria with a Focus on Their Antiviral and Antifungal Properties","volume":"102","author":"Arena","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.anaerobe.2015.04.014","article-title":"Antibacterial Activity of Lactobacillus Spp. Isolated from the Feces of Healthy Infants against Enteropathogenic Bacteria","volume":"34","author":"Davoodabadi","year":"2015","journal-title":"Anaerobe"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12602-012-9117-8","article-title":"The Genus Lactobacillus: A Taxonomic Update","volume":"4","author":"Salvetti","year":"2012","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1700144","DOI":"10.1002\/mnfr.201700144","article-title":"Differential Intestinal Anti-Inflammatory Effects of Lactobacillus Fermentum and Lactobacillus Salivarius in DSS Mouse Colitis: Impact on MicroRNAs Expression and Microbiota Composition","volume":"61","author":"Algieri","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MPG.0b013e3182333f18","article-title":"Human Milk Probiotic Lactobacillus Fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants","volume":"54","author":"Maldonado","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"G669","DOI":"10.1152\/ajpgi.00188.2010","article-title":"Protective Effects of Lactobacillus Paracasei F19 in a Rat Model of Oxidative and Metabolic Hepatic Injury","volume":"299","author":"Nardone","year":"2010","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Krogius-Kurikka, L., Lyra, A., Malinen, E., Aarnikunnas, J., Tuimala, J., Paulin, L., M\u00e4kivuokko, H., Kajander, K., and Palva, A. (2009). Microbial Community Analysis Reveals High Level Phylogenetic Alterations in the Overall Gastrointestinal Microbiota of Diarrhoea-Predominant Irritable Bowel Syndrome Sufferers. BMC Gastroenterol., 9.","DOI":"10.1186\/1471-230X-9-95"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1099\/mic.0.043257-0","article-title":"Gastrointestinal Microbiota in Irritable Bowel Syndrome: Present State and Perspectives","volume":"156","author":"Salonen","year":"2010","journal-title":"Microbiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"710052","DOI":"10.3389\/fphar.2021.710052","article-title":"Construction of a \u201cBacteria-Metabolites\u201d Co-Expression Network to Clarify the Anti-Ulcerative Colitis Effect of Flavonoids of Sophora Flavescens Aiton by Regulating the \u201cHost-Microbe\u201d Interaction","volume":"12","author":"Shao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and \u0160trukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel Disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4174\/astr.2021.101.5.281","article-title":"The Effect of Probiotics Supplementation in Postoperative Cancer Patients: A Prospective Pilot Study","volume":"101","author":"Kwon","year":"2021","journal-title":"Ann. Surg. Treat. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3389\/fmicb.2019.01809","article-title":"Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice","volume":"10","author":"Salazar","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1476-511X-10-116","article-title":"Antiobesity and Lipid-Lowering Effects of Bifidobacterium Spp. in High Fat Diet-Induced Obese Rats","volume":"10","author":"An","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/npjbiofilms.2016.9","article-title":"Oral Treatment with Eubacterium Hallii Improves Insulin Sensitivity in Db\/Db Mice","volume":"2","author":"Udayappan","year":"2016","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Xiao, X., Li, M., Yu, M., Ping, F., Zheng, J., Wang, T., and Wang, X. (2017). Vildagliptin Increases Butyrate-Producing Bacteria in the Gut of Diabetic Rats. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184735"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1462-2920.2009.02066.x","article-title":"Diversity of Human Colonic Butyrate-Producing Bacteria Revealed by Analysis of the Butyryl-CoA:Acetate CoA-Transferase Gene","volume":"12","author":"Louis","year":"2010","journal-title":"Environ. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1128\/AEM.70.10.5810-5817.2004","article-title":"Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product","volume":"70","author":"Duncan","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1574-6941.2011.01085.x","article-title":"Kinetic Modelling of Lactate Utilization and Butyrate Production by Key Human Colonic Bacterial Species","volume":"76","author":"Laroche","year":"2011","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1038\/s41467-021-25081-w","article-title":"Conversion of Dietary Inositol into Propionate and Acetate by Commensal Anaerostipes Associates with Host Health","volume":"12","author":"Bui","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tem.2015.11.008","article-title":"The Role of Cholesterol in the Pathogenesis of NASH","volume":"27","author":"Ioannou","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_39","first-page":"218","article-title":"Lactic Acid Bacteria: Their Antimicrobial Compounds and Their Uses in Food Production","volume":"1","author":"Rattanachaikunsopon","year":"2010","journal-title":"Sch. Res. Libr. Ann. Biol. Res."},{"key":"ref_40","first-page":"165","article-title":"Colonization of the Digestive Tract of Germ-Free Mice by Genetically Engineered Strains of Lactococcus Lactis: Study of Recombinant DNA Stability","volume":"1","author":"Gruzza","year":"1992","journal-title":"Microb. Releases Viruses Bact. Fungi"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1128\/aem.61.7.2771-2774.1995","article-title":"Genetic Marking of Lactococcus Lactis Shows Its Survival in the Human Gastrointestinal Tract","volume":"61","author":"Klijn","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3354\/dao03083","article-title":"Lactococcus Garvieae: An Emerging Bacterial Pathogen of Fish","volume":"123","author":"Meyburgh","year":"2017","journal-title":"Dis. Aquat. Organ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3168\/jds.2018-14983","article-title":"Probiotic Potential and Biochemical and Technological Properties of Lactococcus Lactis Ssp. Lactis Strains Isolated from Raw Milk and Kefir Grains","volume":"102","author":"Yerlikaya","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"001397","DOI":"10.1099\/jmm.0.001397","article-title":"Complete Genome Sequence and Probiotic Properties of Lactococcus Petauri LZys1 Isolated from Healthy Human Gut","volume":"70","author":"Li","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e00797-20","DOI":"10.1128\/mSystems.00797-20","article-title":"Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson\u2019s Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder","volume":"5","author":"Nishiwaki","year":"2020","journal-title":"mSystems"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cani, P.D., de Hase, E.M., and van Hul, M. (2021). Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061302"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1849998","DOI":"10.1080\/19490976.2020.1849998","article-title":"From Correlation to Causality: The Case of Subdoligranulum","volume":"12","author":"Prifti","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_48","first-page":"1183","article-title":"Characteristics of Gut Microbial Profiles of Offshore Workers and Its Associations with Diet","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"18486","DOI":"10.1038\/s41598-021-98075-9","article-title":"Distinguishing Feature of Gut Microbiota in Tibetan Highland Coronary Artery Disease Patients and Its Link with Diet","volume":"11","author":"Ma","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00223-21","DOI":"10.1128\/Spectrum.00223-21","article-title":"Gut Microbiota Serves a Predictable Outcome of Short-Term Low-Carbohydrate Diet (LCD) Intervention for Patients with Obesity","volume":"9","author":"Zhang","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1038\/s41598-021-84928-w","article-title":"Gut Microbiota Markers Associated with Obesity and Overweight in Italian Adults","volume":"11","author":"Palmas","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"13424","DOI":"10.1038\/s41598-019-49462-w","article-title":"Discrepant Gut Microbiota Markers for the Classification of Obesity-Related Metabolic Abnormalities","volume":"9","author":"Zeng","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.celrep.2018.12.028","article-title":"Parabacteroides Distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/gutjnl-2017-315458","article-title":"Gut Commensal Parabacteroides Goldsteinii Plays a Predominant Role in the Anti-Obesity Effects of Polysaccharides Isolated from Hirsutella Sinensis","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1099\/ijsem.0.000824","article-title":"Proposal to Restrict the Genus Clostridium Prazmowski to Clostridium Butyricum and Related Species","volume":"66","author":"Lawson","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_56","first-page":"49","article-title":"Isolation of Clostridium Limosum from an Outbreak of Metritis in Farmed Mink","volume":"58","author":"Heinikainen","year":"2016","journal-title":"Acta Vet. Scand."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e05371","DOI":"10.1016\/j.heliyon.2020.e05371","article-title":"Small, but Smelly: The Importance of Solobacterium Moorei in Halitosis and Other Human Infections","volume":"6","author":"Barrak","year":"2020","journal-title":"Heliyon"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Alauzet, C., Aujoulat, F., Lozniewski, A., Brahim, S., Domenjod, C., Enault, C., Lavigne, J.P., and Marchandin, H. (2021). A New Look at the Genus Solobacterium: A Retrospective Analysis of Twenty-Seven Cases of Infection Involving S. Moorei and a Review of Sequence Databases and the Literature. Microorganisms, 9.","DOI":"10.3390\/microorganisms9061229"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e4458","DOI":"10.7717\/peerj.4458","article-title":"Characterization of the Salivary Microbiome in People with Obesity","volume":"2018","author":"Wu","year":"2018","journal-title":"PeerJ"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1053\/j.gastro.2021.02.021","article-title":"Dieting for Success: What Baseline Gut Microbiota Can Tell You About Your Chances of Losing Weight","volume":"160","author":"Reimer","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nutres.2020.09.002","article-title":"Obesity-Induced Alterations in the Gut Microbiome in Female Mice Fed a High-Fat Diet Are Antagonized by Dietary Supplementation with a Novel, Wax Ester-Rich, Marine Oil","volume":"83","author":"Schots","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"876","DOI":"10.4315\/0362-028X-50.10.876","article-title":"Carbohydrate Metabolism by Streptococcus Thermophilus: A Review","volume":"50","author":"Hutkins","year":"1987","journal-title":"J. Food Prot."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/19490976.2019.1592420","article-title":"High Intake of Dietary Fructose in Overweight\/Obese Teenagers Associated with Depletion of Eubacterium and Streptococcus in Gut Microbiome","volume":"10","author":"Jones","year":"2019","journal-title":"Gut Microbes"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1017\/S0007114519001909","article-title":"The Association between Gut Microbiota Composition and BMI in Chinese Male College Students, as Analysed by next-Generation Sequencing","volume":"122","author":"Lv","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3389\/fmicb.2021.711359","article-title":"Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat","volume":"12","author":"Nogal","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chom.2019.07.004","article-title":"Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition","volume":"26","author":"Thingholm","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1099\/ijsem.0.000617","article-title":"Alistipes Inops Sp. Nov. and Coprobacter Secundus Sp. Nov., Isolated from Human Faeces","volume":"65","author":"Shkoporov","year":"2015","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Duan, M., Wang, Y., Zhang, Q., Zou, R., Guo, M., and Zheng, H. (2021). Characteristics of Gut Microbiota in People with Obesity. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255446"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hu, H.J., Park, S.G., Jang, H.B., Choi, M.G., Park, K.H., Kang, J.H., Park, S.I., Lee, H.J., and Cho, S.H. (2015). Obesity Alters the Microbial Community Profile in Korean Adolescents. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138015"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","article-title":"Polysaccharide Utilization by Gut Bacteria: Potential for New Insights from Genomic Analysis","volume":"6","author":"Flint","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"ref_72","first-page":"235722","article-title":"Effect of Dietary Carbohydrate Restriction on an Obesity-Related Prevotella-Dominated Human Fecal Microbiota","volume":"2","author":"Latorre","year":"2013","journal-title":"Metagenomics"},{"key":"ref_73","first-page":"516","article-title":"Taxonomic Characterization and Short-Chain Fatty Acids Production of the Obese Microbiota","volume":"11","author":"Requena","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100706","DOI":"10.1016\/j.nmni.2020.100706","article-title":"Megasphaera Vaginalis Sp. Nov. and Anaerococcus vaginimassiliensis sp. nov., New Bacteria Isolated from Vagina of French Woman with Bacterial Vaginosis","volume":"37","author":"Bordigoni","year":"2020","journal-title":"New Microbes New Infect."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3389\/fphar.2018.01354","article-title":"Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines","volume":"9","author":"Feng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3389\/fmicb.2016.01945","article-title":"Comparative In Silico Analysis of Butyrate Production Pathways in Gut Commensals and Pathogens","volume":"7","author":"Anand","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Deng, K., Shuai, M., Zhang, Z., Jiang, Z., Fu, Y., Shen, L., Zheng, J.-S., and Chen, Y. (2022). Temporal Relationship among Adiposity, Gut Microbiota, and Insulin Resistance in a Longitudinal Human Cohort. BMC Med., 20.","DOI":"10.1186\/s12916-022-02376-3"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13059-019-1831-z","article-title":"Gut Microbiome Composition in the Hispanic Community Health Study\/Study of Latinos Is Shaped by Geographic Relocation, Environmental Factors, and Obesity","volume":"20","author":"Kaplan","year":"2019","journal-title":"Genome Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.mayocp.2018.02.019","article-title":"Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention with a Volumetric Diet","volume":"93","author":"Jensen","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11789","DOI":"10.1038\/s41598-017-10722-2","article-title":"Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in Healthy Young Population","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1007\/s00253-020-10689-7","article-title":"A Comparative Study of Microbial Community and Functions of Type 2 Diabetes Mellitus Patients with Obesity and Healthy People","volume":"104","author":"Wang","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1880221","DOI":"10.1080\/19490976.2021.1880221","article-title":"Elevated Gut Microbiome Abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae Is Associated with Reduced Visceral Adipose Tissue and Healthier Metabolic Profile in Italian Elderly","volume":"13","author":"Tavella","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.clnu.2022.06.007","article-title":"Gut Microbiota Is Associated with Metabolic Health in Children with Obesity","volume":"41","author":"Alcazar","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41538-022-00133-7","article-title":"Effects of High Fructose Corn Syrup on Intestinal Microbiota Structure and Obesity in Mice","volume":"6","author":"Wang","year":"2022","journal-title":"NPJ Sci. Food"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41396-019-0363-6","article-title":"Genomic Insights from Monoglobus Pectinilyticus: A Pectin-Degrading Specialist Bacterium in the Human Colon","volume":"13","author":"Kim","year":"2019","journal-title":"ISME J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"fuaa052","DOI":"10.1093\/femsre\/fuaa052","article-title":"Tripartite Relationship between Gut Microbiota, Intestinal Mucus and Dietary Fibers: Towards Preventive Strategies against Enteric Infections","volume":"45","author":"Sauvaitre","year":"2021","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Ahrens, A.P., Culpepper, T., Saldivar, B., Anton, S., Stoll, S., Handberg, E.M., Xu, K., Pepine, C., Triplett, E.W., and Aggarwal, M. (2021). A Six-Day, Lifestyle-Based Immersion Program Mitigates Cardiovascular Risk Factors and Induces Shifts in Gut Microbiota, Specifically Lachnospiraceae, Ruminococcaceae, Faecalibacterium Prausnitzii: A Pilot Study. Nutrients, 13.","DOI":"10.3390\/nu13103459"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"101167","DOI":"10.1016\/j.fbio.2021.101167","article-title":"Gut Modulation of Dysbiosis Induced by Dextran Sulfate Sodium","volume":"42","author":"Kozhakhmetov","year":"2021","journal-title":"Food Biosci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yu, Z., Yu, X.-F., Zhao, X., and Ren, P.-G. (2022). Greater Alteration of Gut Microbiota Occurs in Childhood Obesity than Adulthood Obesity. bioRxiv, 492992.","DOI":"10.1101\/2022.05.22.492992"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1099\/0022-1317-49-7-583","article-title":"Shigella and Escherichia Coli at the Crossroads: Machiavellian Masqueraders or Taxonomic Treachery?","volume":"49","author":"Johnson","year":"2000","journal-title":"J. Med. Microbiol."},{"key":"ref_91","unstructured":"van der Putten, B.C.L., Matamoros, S., Schultsz, C., Arcilla, M.S., Bootsma, M.C.J., van Genderen, P.J., Goorhuis, A., Grobusch, M., van Hattem, J.M., and de Jong, M.D. (2019). Genomic Evidence for Revising the Escherichia Genus and Description of Escherichia ruysiae sp. nov. bioRxiv, 781724."},{"key":"ref_92","first-page":"323","article-title":"Pseudomonas Migula 1894 (Nom. Cons., Opin. 5 of the Jud. Comm. 1952, 121)","volume":"Volume 2","author":"Palleroni","year":"2005","journal-title":"Bergey\u2019s Manual of Systematic Bacteriology, The Proteobacteria, Part B the Gammaproteobacteria"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1073\/pnas.1105168108","article-title":"Whole-Genome Phylogeny of Escherichia Coli\/Shigella Group by Feature Frequency Profiles (FFPs)","volume":"108","author":"Sims","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"694967","DOI":"10.1155\/2014\/694967","article-title":"Metabolic Modeling of Common Escherichia Coli Strains in Human Gut Microbiome","volume":"2014","author":"Gao","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"804455","DOI":"10.3389\/fendo.2022.804455","article-title":"Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight\/Obesity Within the Frame of the PREDIMED-Plus Study","volume":"13","author":"Atzeni","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_96","unstructured":"Tomnikov, N. (2022). Optimization of Microbial DNA Extraction in 96-Format from Fecal Samples for Next Generation Sequencing. [Master\u2019s Thesis, University of Turku]."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"808991","DOI":"10.3389\/fcimb.2022.808991","article-title":"Significant Succession of Intestinal Bacterial Community and Function During the Initial 72 Hours of Acute Pancreatitis in Rats","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Yang, W.Y., Lee, Y., Lu, H., Chou, C.H., and Wang, C. (2019). Analysis of Gut Microbiota and the Effect of Lauric Acid against Necrotic Enteritis in Clostridium Perfringens and Eimeria Side-by-Side Challenge Model. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0205784"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"529","DOI":"10.5056\/jnm20004","article-title":"The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity","volume":"26","author":"Li","year":"2020","journal-title":"J. Neurogastroenterol. Motil."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/16\/3384\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:11:27Z","timestamp":1760141487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/16\/3384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":99,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["nu14163384"],"URL":"https:\/\/doi.org\/10.3390\/nu14163384","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,18]]}}}