{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:58:51Z","timestamp":1782511131025,"version":"3.54.5"},"reference-count":22,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In preterm newborns, secondary hyperparathyroidism (HPTH) is an underdiagnosed and undertreated entity. Its detection in the context of metabolic bone mineral disease (MBD) screening programs may be important to guide nutritional treatment. We designed a retrospective cohort study to determine the incidence of HPTH in very premature infants. As secondary objectives, we studied the risk factors, morbidities, and biochemical alterations associated with HPTH. A total of 154 preterm newborns \u226432 weeks gestational age (GA) were included. Of these, 40.3% (n = 62) presented with HPTH. In the multivariate analysis, independent risk factors for HPTH were cesarean section (OR: 4.00; 95% CI: 1.59\u201310.06), oxygen during resuscitation (OR: 3.43; 95% CI: 1.09\u201310.81), invasive mechanical ventilation (OR: 3.56; 95% CI: 1.63\u20137.77) and anemia requiring transfusion (OR: 2.37; 95% CI: 1.01\u20135.57). Among the analytical variables, serum calcium (OR: 0.53; 95% CI: 0.29\u20130.97), serum phosphate (OR: 2.01; 95% CI: 1.39\u20132.92), vitamin D (OR: 0.96; 95% CI: 0.93\u20131), and the calcium\/creatinine ratio in urine (OR: 0.05; 95% CI: 0.01\u20130.28) were independently associated with HPTH. The simplified predictive model included GA and calcium\/creatinine ratio in urine and demonstrated an AUC of 0.828. We concluded that HPTH is a frequent entity among very premature infants and that further studies are required to determine the role of HPTH in MBD and the clinical applicability of prediction models.<\/jats:p>","DOI":"10.3390\/nu14163397","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T23:28:41Z","timestamp":1660865321000},"page":"3397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence, Risk Factors and Prediction of Secondary Hyperparathyroidism in Preterm Neonates under 32 Weeks\u2019 Gestational Age"],"prefix":"10.3390","volume":"14","author":[{"given":"Alejandro","family":"Avila-Alvarez","sequence":"first","affiliation":[{"name":"Neonatology Unit, Pediatrics Department, Complexo Hospitalario Universitario de A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"},{"name":"INIBIC-Health Research Institute of A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-9523","authenticated-orcid":false,"given":"Helena","family":"Perez Tato","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Pediatrics Department, Complexo Hospitalario Universitario de A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sucasas Alonso","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Pediatrics Department, Complexo Hospitalario Universitario de A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Prado Carro","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Pediatrics Department, Complexo Hospitalario Universitario de A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Fuentes Carballal","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Pediatrics Department, Complexo Hospitalario Universitario de A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101069","DOI":"10.1016\/j.siny.2019.101069","article-title":"History, epidemiology and prevalence of neonatal bone mineral metabolic disorders","volume":"25","author":"Schulz","year":"2020","journal-title":"Semin. 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