{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:56:38Z","timestamp":1783468598374,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig"},{"name":"European Union"},{"name":"the European Regional Development Fund (ERDF)"},{"name":"Free State of Saxony"},{"name":"Thermo Fisher"},{"name":"Roche Diagnostics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Knowledge about cardiac and inflammatory biomarkers in patients with stable coronary artery disease (CAD) is limited. To address this, we analyzed 3072 patients (36% female) with a median follow-up of 10 years in the Leipzig LIFE Heart Study with suspected CAD with coronary angiography. Selected biomarkers included troponin T (hsTNT), N-terminal pro B-type natriuretic peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), and interleukin-6 (IL-6). Patients were stratified by CAD severity: CAD0 (no sclerosis), CAD1 (non-obstructive, i.e., stenosis &lt; 50%), and CAD2 (\u2265one stenosis \u2265 50%). Group comparison (GC) included GC1: CAD0 + 1 vs. CAD2; GC2: CAD0 vs. CAD1 + 2. CAD0, CAD1, and CAD2 were apparent in 1271, 631, and 1170 patients, respectively. Adjusted for classical risk factors, hs-cTnT, NT-proBNP, and IL-6 differed significantly in both GC and hsCRP only in GC2. After multivariate analysis, hs-cTnT, NT-proBNP, and IL-6 remained significant in GC1. In GC2, hs-cTnT (p &lt; 0.001) and copeptin (p = 0.014) reached significance. Ten-year survival in groups CAD0, CAD1, and CAD2 was 88.3%, 77.3%, and 72.4%. Incorporation of hs-cTnT, NT-proBNP, copeptin, and IL-6 improved risk prediction (p &lt; 0.001). The studied cardiac and inflammatory biomarkers enable fast and precise non-invasive identification of mortality risk in CAD patients, allowing the tailoring of primary and secondary CAD prevention.<\/jats:p>","DOI":"10.3390\/nu14163433","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:56:40Z","timestamp":1661133400000},"page":"3433","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biomarkers for Non-Invasive Stratification of Coronary Artery Disease and Prognostic Impact on Long-Term Survival in Patients with Stable Coronary Heart Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-3936","authenticated-orcid":false,"given":"Jeffrey","family":"Netto","sequence":"first","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Teren","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Department of Cardiology and Intensive Care Medicine, University Hospital OWL, Campus Klinikum Bielefeld, 33604 Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-1202","authenticated-orcid":false,"given":"Ralph","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Willenberg","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beutner","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Henger","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schuler","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig at University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-6160","authenticated-orcid":false,"given":"Berend","family":"Isermann","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Thiery","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Faculty of Medical, Christian-Albrechts-Unversity Kiel, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Scholz","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-3113","authenticated-orcid":false,"given":"Thorsten","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, 04109 Leipzig, Germany"},{"name":"Institute for Laboratory Medicine, Microbiology and Pathobiochemistry, University Hospital Ostwestfalen-Lippe (UK-OWL), Campus Klinikum Lippe, Bielefeld University, 33615 Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.atherosclerosis.2016.05.037","article-title":"2016 European Guidelines on Cardiovascular 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