{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:28:34Z","timestamp":1791851314973,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospices Civils de Lyon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Maintenance hemodialysis induces water-soluble vitamins and trace elements losses, which is why recommendations regarding potential supplementation were provided, but mainly based on conventional hemodialysis. This study\u2032s aim was to measure the water\u2013soluble vitamins and trace element losses during one on-line post-dilution hemodiafiltration (HDF) session. Thirty-nine patients under maintenance HDF were enrolled. We used the Theraflux\u00ae sampler (Theradial Corp., Orvault, France) to analyze the full session dialysate mass transfer. Blood and dialysate samples were collected before and after one HDF session to measure B1, B2, B6, B9, B12, C vitamins, zinc, and selenium concentrations. Values significantly decreased for B1 (20.2%), B2 (13%), B6 (25.4%), B9 (32.6%), C (66.6%) and selenium (6.7%). No significant differences were found for vitamin B12 and zinc. The dialysate losses per session were 1.12 \u00b1 0.88 mg for vitamin B1, 0.28 \u00b1 0.30 mg for B2, 0.33 \u00b1 0.09 mg for B6, 0.3 \u00b1 0.18 mg for B9, 147.5 \u00b1 145.50 mg for C and 25.75 \u00b1 6.91 mg for zinc. Vitamin B12 and selenium were under detection values. In conclusion, during a standard 4hr-HDF session, we found important losses for vitamin B1, B6, B9, C and zinc, suggesting the need for regular monitoring of plasma levels and systematic supplementation of these compounds.<\/jats:p>","DOI":"10.3390\/nu14173454","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:22:48Z","timestamp":1661300568000},"page":"3454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Water-Soluble Vitamins and Trace Elements Losses during On-Line Hemodiafiltration"],"prefix":"10.3390","volume":"14","author":[{"given":"Alban","family":"B\u00e9vier","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Nutrition, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-3572","authenticated-orcid":false,"given":"Etienne","family":"Novel-Catin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Nutrition, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Blond","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"},{"name":"INSERM U1060, CarMeN Laboratory, Lyon 1 Claude Bernard University, INRAE U1397, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenne","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Nutrition, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Parant","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-2420","authenticated-orcid":false,"given":"Laetitia","family":"Koppe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Nutrition, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"},{"name":"INSERM U1060, CarMeN Laboratory, Lyon 1 Claude Bernard University, INRAE U1397, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Fouque","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Nutrition, Hospices Civils de Lyon, Lyon Sud Hospital, 69495 Pierre B\u00e9nite, France"},{"name":"INSERM U1060, CarMeN Laboratory, Lyon 1 Claude Bernard University, INRAE U1397, 69495 Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000169398","article-title":"Vitamin levels in chronic renal failure and need for supplementation","volume":"3","author":"Stein","year":"1985","journal-title":"Blood Purif."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"131928","DOI":"10.1038\/ki.1993.185","article-title":"Water soluble vitamins in chronic hemodialysis patients and need for supplementation","volume":"43","author":"Descombes","year":"1993","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/sdi.12099","article-title":"Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: A review","volume":"26","author":"Clase","year":"2013","journal-title":"Semin. 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