{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:25:41Z","timestamp":1781177141153,"version":"3.54.1"},"reference-count":29,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a"},{"name":"Fundaci\u00f3n Estudios Metab\u00f3licos"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The Circadian Locomotor Output Cycles Kaput (CLOCK) gene has been linked to metabolic dysfunction and obesity. The purpose of this study was to analyze the association between single nucleotide polymorphisms (SNPs) of CLOCK gene with obesity and with long-term weight response after different bariatric surgery (BS) techniques. The cohort includes 375 patients with morbid obesity (MO) and 230 controls. In the association study of SNPs with weight response we combined several variables as phenotype at 6 years after surgery. The study protocol was registered in ISRCTN (ID80961259). The analysis of the selected SNPs was performed by allelic discrimination using Taqman\u00ae probes. The genotype association study was performed using the SNPStats program, with comparisons adjusted for sex, age, initial Body Mass Index, type 2 diabetes and hypertension diagnosis, and type of surgery. In the case-control study two of three SNPs were significantly associated with MO. The variant rs1801260 had a protective effect for MO whereas the TT genotype of rs3749474 variant had the strongest association with MO (OR = 2.25 (1.39\u20133.66); p = 0.0006). In the linear regression analysis both variants showed significant association with long-term weight loss and weight regain after BS, independently of the pre-surgery patient profile.<\/jats:p>","DOI":"10.3390\/nu14173472","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T23:48:58Z","timestamp":1661384938000},"page":"3472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8071-8976","authenticated-orcid":false,"given":"Macarena","family":"Torrego-Ellacur\u00eda","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Barabash","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-3755","authenticated-orcid":false,"given":"Pilar","family":"Mat\u00eda-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"S\u00e1nchez-Pernaute","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Department of Surgery, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Department of Surgery, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-9323","authenticated-orcid":false,"given":"Alfonso L.","family":"Calle-Pascual","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-6240","authenticated-orcid":false,"given":"Miguel A.","family":"Rubio-Herrera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant nice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1093\/ajcn\/87.6.1606","article-title":"Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity","volume":"87","author":"Sookoian","year":"2008","journal-title":"Am. 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