{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:16:46Z","timestamp":1791908206956,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Chronic Kidney Disease (CKD) induces metabolic derangement of amino acid (AA) kinetics, eliciting severe damage to the protein anabolism. This damage is further intensified by a significant loss of AAs through hemodialysis (HD), affecting all tissues with a high metabolic turnover, such as the myocardium and body muscle mass. (2) Aim: to illustrate the effects of a novel AA mixture in boosting mitochondrial energy production. (3) Methods: A strict selection of 164 dialysis patients was carried out, allowing us to finally identify 22 compliant patients who had not used any form of supplements over the previous year. The study design envisaged a 6-month randomized, double-blind trial for the comparison of two groups of hemodialysis patients: eleven patients (67.2 \u00b1 9.5 years) received the novel AA mix (TRG), whilst the other eleven (68.2 \u00b1 10.5 years) were given a placebo mix that was indistinguishable from the treatment mix (PLG). (4) Results: Despite the 6-month observation period, the following were observed: maintenance of target hemoglobin values with a reduced need for erythropoiesis-stimulating agents in TRG &gt; 36% compared to PLG (p &lt; 0.02), improved phase angle (PhA) accompanied by an increase in muscle mass solely in the TRG group (p &lt; 0.05), improved Left Ventricular Ejection Fraction (LVEF &gt; 67%) in the TRG versus PLG group (p &lt; 0.05) with early but marked signs of improved diastolic function. Increased sensitivity to insulin with greater control of glycemic levels in TRG versus PLG (p = 0.016). (5) Conclusions: the new AA mix seemed to be effective, showing a positive result on nutritional metabolism and cardiac performance, stable hemoglobin levels with the need for lower doses of erythropoietin (EPO), insulin increased cell sensitivity, better muscle metabolism with less loss of mass.<\/jats:p>","DOI":"10.3390\/nu14173492","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:04:32Z","timestamp":1661479472000},"page":"3492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of a Novel Amino Acid Formula on Nutritional and Metabolic Status, Anemia and Myocardial Function in Thrice-Weekly Hemodialysis Patients: Results of a Six-Month Randomized Double-Blind Placebo-Controlled Pilot Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Stefano","family":"Murtas","sequence":"first","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Aquilani","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cLazzaro Spallanzani\u201d, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Fiori","sequence":"additional","affiliation":[{"name":"Cardiology Service\u2014Quartu-Parteolla Health District, ASL of Cagliari, Quartu Sant\u2019Elena, 09045 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-0430","authenticated-orcid":false,"given":"Roberto","family":"Maestri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Scientific Institute of Montescano, IRCCS, ICS Maugeri S.p.A SB, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Iadarola","sequence":"additional","affiliation":[{"name":"Department of Molecular, Medicine University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Graccione","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Contu","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Deiana","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Macis","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Secci","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Serra","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Cadeddu","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"D\u2019Amato","sequence":"additional","affiliation":[{"name":"Department of Molecular, Medicine University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Putzu","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Marongiu","sequence":"additional","affiliation":[{"name":"Nephrology Department, ASL of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-2342","authenticated-orcid":false,"given":"Piergiorgio","family":"Bolasco","sequence":"additional","affiliation":[{"name":"Chronic Kidney Disease Treatment Conservative Study Group of the Italian Society of Nephrology, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1681\/ASN.2021081044","article-title":"Inflammation, serum iron, and risk of mortality and cardiovascular events in non dialysis CKD patients","volume":"33","author":"Rostoker","year":"2022","journal-title":"J. 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