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University","award":["82073486"],"award-info":[{"award-number":["82073486"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["U1803124"],"award-info":[{"award-number":["U1803124"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["2021SK2026"],"award-info":[{"award-number":["2021SK2026"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["2019JJ40397"],"award-info":[{"award-number":["2019JJ40397"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["202112010058"],"award-info":[{"award-number":["202112010058"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["2021zzts0325"],"award-info":[{"award-number":["2021zzts0325"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["2021zzts0966"],"award-info":[{"award-number":["2021zzts0966"]}]},{"name":"Graduate Research Innovation Program of Central South University","award":["2021zzts0970"],"award-info":[{"award-number":["2021zzts0970"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Vitamin D may have a role in insulin sensitivity. However, the data on the association between various metabolites of Vitamin D and insulin-related parameters have been limited. Methods: We identified 6026 adults aged 20\u201380 years who participated in the 2011\u20132016 National Health and Nutrition Examination Survey (NHANES). Serum total 25OHD, 25OHD3, and epi-25OHD3, fasting glucose, insulin, and HOMA2-IR were obtained from the NHANES data. The association between serum Vitamin D-related values and insulin resistance was analyzed using a generalized linear model. For risk analysis, multifactorial logistic regression was used. Results: The median total 25-hydroxyvitamin D level, 25-hydroxyvitamin D3 level, and 3-epi-25-hydroxyvitamin D3 level were 62.5 nmol\/L, 58.8 nmol\/L, and 3.3 nmol\/L, respectively. After adjustment for sex, age, race, ethnicity, and education status, the ORs for the insulin resistance of participants of total 25-hydroxyvitamin D, 25-hydroxyvitamin D3, and 3-epi-25-hydroxyvitamin D3 were 0.32 (95% CI 0.24, 0.43), 0.34 (95% CI 0.26, 0.44), and 0.64 (95% CI 0.53, 0.77), respectively. After an adjustment for body mass index, diabetes, and drinking and smoking, the ORs for the insulin resistance of the participants for total 25-hydroxyvitamin D, 25-hydroxyvitamin D3, and 3-epi-25-hydroxyvitamin D3 were 0.56 (95% CI 0.40, 0.78), 0.63 (95% CI 0.46, 0.85), and 0.99 (95% CI 0.80, 1.24), respectively. Conclusions: Our study provides suggestive evidence for the association between Vitamin D concentrations and a lower risk of insulin resistance. Evidence from larger and more adequately powered cohort studies is needed to confirm our results.<\/jats:p>","DOI":"10.3390\/nu14173526","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:53:42Z","timestamp":1661813622000},"page":"3526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations of Serum Total 25OHD, 25OHD3, and epi-25OHD3 with Insulin Resistance: Cross-Sectional Analysis of the National Health and Nutrition Examination Survey, 2011\u20132016"],"prefix":"10.3390","volume":"14","author":[{"given":"Meiling","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.rdc.2012.03.006","article-title":"Low vitamin D status: Definition, prevalence, consequences, and correction","volume":"38","author":"Binkley","year":"2012","journal-title":"Rheum. 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