{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:29:32Z","timestamp":1789057772847,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["BMRC\/08\/1\/21\/19\/567"],"award-info":[{"award-number":["BMRC\/08\/1\/21\/19\/567"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["NMRC\/1108\/2007"],"award-info":[{"award-number":["NMRC\/1108\/2007"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Agency for Science, Technology and Research (A*STAR) Biomedical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CIRG\/1409\/2014"],"award-info":[{"award-number":["NMRC\/CIRG\/1409\/2014"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["BMRC\/08\/1\/21\/19\/567"],"award-info":[{"award-number":["BMRC\/08\/1\/21\/19\/567"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/1108\/2007"],"award-info":[{"award-number":["NMRC\/1108\/2007"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CIRG\/1409\/2014"],"award-info":[{"award-number":["NMRC\/CIRG\/1409\/2014"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged \u2265 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD \u00b1 221] vs. 510 [SD \u00b1 290] pmol\/L, p = 0.026), higher homocysteine (14.6 [SD \u00b1 4.2] vs. 12.9 [SD \u00b1 4.3], p = 0.018) and lower one-carbon index (Z-scores: \u22120.444 [SD \u00b1 0.819] vs. \u22120.001 [SD \u00b1 0.990], p = 0.006). Adjusted for confounders, significant associations with incident NCD were found for lower vitamin B12 (per-SD OR = 2.10, 95%CI = 1.26\u20133.52), higher homocysteine (per-SD OR = 1.96, 95%CI = 1.18\u20133.24) and lower one-carbon index (per-SD OR = 1.67, 95%CI = 1.06\u20132.64). Folate was not significantly associated with progression to NCD. Notably, low B12 in the presence of high folate was significantly associated with incident NCD (adjusted OR = 3.81, 95%CI = 1.04\u201313.9). Low B12, high homocysteine, low B12 in the presence of high folate, and a one-carbon index of hypo-methylation were independently associated with progression to NCD among cognitively normal.<\/jats:p>","DOI":"10.3390\/nu14173535","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T22:53:42Z","timestamp":1661813622000},"page":"3535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults"],"prefix":"10.3390","volume":"14","author":[{"given":"Paulina Maria","family":"Przybycien-Gaweda","sequence":"first","affiliation":[{"name":"Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tih Shih","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobehavioural Genomics, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-7230","authenticated-orcid":false,"given":"Wee Shiong","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Active Aging, Tan Tock Seng Hospital, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308433, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Sian","family":"Chong","sequence":"additional","affiliation":[{"name":"Geriatric Education and Research Institute, Singapore 768024, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Yee","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Rawtaer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Sengkang General Hospital, Singapore 544886, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-7752","authenticated-orcid":false,"given":"Tau Ming","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Gwee","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore 308433, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Bee","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ng Teng Fong General Hospital, Singapore 609606, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-855X","authenticated-orcid":false,"given":"Tze Pin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Geriatric Education and Research Institute, Singapore 768024, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41582-020-0348-0","article-title":"An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders","volume":"16","author":"Ashton","year":"2020","journal-title":"Nat. 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