{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:11:21Z","timestamp":1776399081459,"version":"3.51.2"},"reference-count":40,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health, \u201cRicerca Corrente\u201d","award":["202105_INNOV_ONETTI"],"award-info":[{"award-number":["202105_INNOV_ONETTI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Obesity has reached epidemic proportions, and the World Health Organization defined childhood overweight and obesity as a noncommunicable disease that represents the most serious public health challenges of the twenty-first century. Oxidative stress, defined as an imbalance between oxidants and antioxidants causing an impairment of the redox signals, is linked to the development of metabolic diseases. In addition, reactive oxygen species generated during metabolic disorder could increase inflammation, causing the development of insulin resistance, diabetes, and cardiovascular disease. We analyze serum levels of cysteine (Cys), cysteinyl-glycine (Cys-Gly), homocysteine (Hcy), and glutathione (GSH), and other markers of oxidative stress, such as thiobarbituric acid reactive substances (T-BARS), 8-isoprostane, and protein carbonyl in our children with obesity. Total antioxidant status was also determined. We found lower GSH and Cys-Gly levels, and higher Hcy and oxidative stress markers levels. We also found a positive correlation between Body Mass Index (BMI), Cys, GSH, and Hcy levels, between insulin and Cys levels, and between BMI and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) with 8-isoprostane levels. Finally, we found a correlation between age and GSH and Cys levels. The deficiency of GSH could be restored by dietary supplementation with GSH precursors, supplying an inexpensive approach to oppose oxidative stress, thus avoiding obesity complications.<\/jats:p>","DOI":"10.3390\/nu14173637","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T01:51:57Z","timestamp":1662515517000},"page":"3637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Study of the Association between Thiols and Oxidative Stress Markers in Children with Obesity"],"prefix":"10.3390","volume":"14","author":[{"given":"Annamaria","family":"D\u2019Alessandro","sequence":"first","affiliation":[{"name":"Clinical Biochemistry Laboratory, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovina","family":"Di Felice","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-975X","authenticated-orcid":false,"given":"Melania","family":"Manco","sequence":"additional","affiliation":[{"name":"Research Unit of Multifactorial and Complexes Phenotype Diseases, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-9419","authenticated-orcid":false,"given":"Anna","family":"Pastore","sequence":"additional","affiliation":[{"name":"Research Unit of Diagnostical and Management Innovations, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Pezzi","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-2529","authenticated-orcid":false,"given":"Michela","family":"Mariani","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, University Pediatric Clinical Department, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Fintini","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, University Pediatric Clinical Department, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-6178","authenticated-orcid":false,"given":"Andrea","family":"Onetti Muda","sequence":"additional","affiliation":[{"name":"Research Unit of Diagnostical and Management Innovations, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-8679","authenticated-orcid":false,"given":"Ottavia","family":"Porzio","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, IRCCS \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, 00165 Rome, Italy"},{"name":"Department of Experimental Medicine, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, June 16). 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