{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:27:56Z","timestamp":1764332876665,"version":"3.46.0"},"reference-count":61,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001656","name":"Helmholtz Association","doi-asserted-by":"publisher","award":["NWG VH-NG-829"],"award-info":[{"award-number":["NWG VH-NG-829"]}],"id":[{"id":"10.13039\/501100001656","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"German Center for Lung Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Else Kr\u00f6ner-Fresenius-Foundation, LMU Medical Faculty and LMU University Hospitals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Very preterm infants are at high risk for suboptimal nutrition in the first weeks of life leading to insufficient weight gain and complications arising from metabolic imbalances such as insufficient bone mineral accretion. We investigated the use of a novel set of standardized parenteral nutrition (PN; MUC PREPARE) solutions regarding improving nutritional intake, accelerating termination of parenteral feeding, and positively affecting growth in comparison to individually prescribed and compounded PN solutions. We studied the effect of MUC PREPARE on macro- and micronutrient intake, metabolism, and growth in 58 very preterm infants and compared results to a historic reference group of 58 very preterm infants matched for clinical characteristics. Infants receiving MUC PREPARE demonstrated improved macro- and micronutrient intake resulting in balanced electrolyte levels and stable metabolomic profiles. Subsequently, improved energy supply was associated with up to 1.5 weeks earlier termination of parenteral feeding, while simultaneously reaching up to 1.9 times higher weight gain at day 28 in extremely immature infants (&lt;27 GA weeks) as well as overall improved growth at 2 years of age for all infants. The use of the new standardized PN solution MUC PREPARE improved nutritional supply and short- and long-term growth and reduced PN duration in very preterm infants and is considered a superior therapeutic strategy.<\/jats:p>","DOI":"10.3390\/nu14193912","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"3912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved Macro- and Micronutrient Supply for Favorable Growth and Metabolomic Profile with Standardized Parenteral Nutrition Solutions for Very Preterm Infants"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-6030","authenticated-orcid":false,"given":"Alida","family":"Kindt","sequence":"first","affiliation":[{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, 85764 Oberschlei\u00dfheim, Germany"},{"name":"Metabolomics and Analytics Center, Leiden Academic Centre for Drug Research, Leiden University, 2333 AL Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Kraus","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Developmental Care (CDeCLMU), Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr von Hauner Children's Hospital, Munich University Hospital, Ludwig Maximilians University, 80336 Munich, Germany"},{"name":"Comprehensive Pneumology Center, Helmholtz Zentrum M\u00fcnchen, Member of the German Lung Research Center (DZL), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-2163","authenticated-orcid":false,"given":"Livia Dahlia","family":"Rasp","sequence":"additional","affiliation":[{"name":"Metabolomics and Analytics Center, Leiden Academic Centre for Drug Research, Leiden University, 2333 AL Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Foerster","sequence":"additional","affiliation":[{"name":"Comprehensive Pneumology Center, Helmholtz Zentrum M\u00fcnchen, Member of the German Lung Research Center (DZL), 81377 Munich, Germany"},{"name":"Department of Neonatology, Perinatal Center, Dr. von Hauner Children\u2019s Hospital, Ludwig-Maximilians University, 80337 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-9964","authenticated-orcid":false,"given":"Narges","family":"Ahmidi","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, 85764 Oberschlei\u00dfheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Flemmer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Center, Dr. von Hauner Children\u2019s Hospital, Ludwig-Maximilians University, 80337 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Herber-Jonat","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Center, Dr. von Hauner Children\u2019s Hospital, Ludwig-Maximilians University, 80337 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-6136","authenticated-orcid":false,"given":"Florian","family":"Heinen","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Developmental Care (CDeCLMU), Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr von Hauner Children's Hospital, Munich University Hospital, Ludwig Maximilians University, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Weigand","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Developmental Care (CDeCLMU), Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr von Hauner Children's Hospital, Munich University Hospital, Ludwig Maximilians University, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-2073","authenticated-orcid":false,"given":"Thomas","family":"Hankemeier","sequence":"additional","affiliation":[{"name":"Metabolomics and Analytics Center, Leiden Academic Centre for Drug Research, Leiden University, 2333 AL Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-7165","authenticated-orcid":false,"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Division of Metabolic and Nutritional Medicine, Department of Paediatrics, Dr. von Hauner Children\u2019s Hospital University Hospital, Ludwig-Maximilians University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Krumsiek","sequence":"additional","affiliation":[{"name":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, 85764 Oberschlei\u00dfheim, Germany"},{"name":"Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Babl","sequence":"additional","affiliation":[{"name":"Pharmacy of the University Hospital, Ludwig-Maximilians University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Hilgendorff","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Developmental Care (CDeCLMU), Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatrics, Dr von Hauner Children's Hospital, Munich University Hospital, Ludwig Maximilians University, 80336 Munich, Germany"},{"name":"Comprehensive Pneumology Center, Helmholtz Zentrum M\u00fcnchen, Member of the German Lung Research Center (DZL), 81377 Munich, Germany"},{"name":"Department of Neonatology, Perinatal Center, Dr. von Hauner Children\u2019s Hospital, Ludwig-Maximilians University, 80337 Munich, 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