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This observational, cross-sectional substudy analyzed DR-related data from 309 T1D and 264 T2D subjects. The advanced lipoprotein and glycoprotein profile was determined by nuclear magnetic resonance (NMR) spectroscopy (Liposcale test). NMR analysis of lipoproteins revealed that T1D subjects with DR showed standard non-HDL particles, despite higher IDL lipid concentrations. Notably, IDL lipids were elevated in T1D subjects with worsened DR. VLDL and LDL were smaller, whereas HDL triglycerides were increased in DR compared with non-DR. On the other hand, the T2D subjects with DR showed altered characteristics in the LDL fraction, mainly revealed by a significant decrease in smaller LDL and a reduction in LDL-C. Moreover, the glycoprotein profile did not reveal significant changes among DR groups, regardless of the type of diabetes. However, lipoprotein characteristics and glycoproteins unveiled by NMR analysis did not improve the predictive value of conventional lipids or other traditional, well-established biomarkers of DR in our cohorts.<\/jats:p>","DOI":"10.3390\/nu14193932","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T23:07:55Z","timestamp":1663888075000},"page":"3932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-2246","authenticated-orcid":false,"given":"Josep","family":"Julve","sequence":"first","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Rossell","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-0469","authenticated-orcid":false,"given":"Eudald","family":"Correig","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Rovira i Virgili University, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-3156","authenticated-orcid":false,"given":"Marina 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Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Traveset","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Arnau de Vilanova University Hospital and Lleida Biomedical Research Institute (IRBLleida), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Germans Trias i Pujol University Hospital, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Alonso","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Endocrinology & Nutrition, Germans Trias i Pujol University Hospital, 08916 Badalona, Spain"},{"name":"Department of Medicine, Autonomous 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