{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:51:40Z","timestamp":1790268700362,"version":"4.1.0"},"reference-count":258,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"The National Centre for Research and Development (NCBiR, Poland)","doi-asserted-by":"publisher","award":["POIR.01.01.01-00-0985\/17"],"award-info":[{"award-number":["POIR.01.01.01-00-0985\/17"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative and brain-related diseases, e.g., Alzheimer\u2019s and Parkinson\u2019s. This review underlines the importance of gut-derived metabolites and gut metabolic status as the main players in gut-brain crosstalk and their implications on the severity of neural conditions. Scientific evidence indicates that the administration of probiotic bacteria exerts beneficial and protective effects as reduced systemic inflammation, neuroinflammation, and inhibited neurodegeneration. The experimental results performed on animals, but also human clinical trials, show the importance of designing a novel microbiota-based probiotic dietary supplementation with the aim to prevent or ease the symptoms of Alzheimer\u2019s and Parkinson\u2019s diseases or other forms of dementia or neurodegeneration.<\/jats:p>","DOI":"10.3390\/nu14193967","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T03:34:17Z","timestamp":1664163257000},"page":"3967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-801X","authenticated-orcid":false,"given":"Ma\u0142gorzata Anna","family":"Mar\u0107","sequence":"first","affiliation":[{"name":"Research and Development Center, Olimp Laboratories Sp. z o.o, Pustynia 84F, 39-200 D\u0119bica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-3626","authenticated-orcid":false,"given":"Rafa\u0142","family":"Jastrz\u0105b","sequence":"additional","affiliation":[{"name":"Research and Development Center, Olimp Laboratories Sp. z o.o, Pustynia 84F, 39-200 D\u0119bica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-973X","authenticated-orcid":false,"given":"Jennifer","family":"Mytych","sequence":"additional","affiliation":[{"name":"Research and Development Center, Olimp Laboratories Sp. z o.o, Pustynia 84F, 39-200 D\u0119bica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A Human Gut Microbial Gene Catalogue Established by Metagenomic Sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/gbb.12109","article-title":"Microbial Genes, Brain & Behaviour\u2014Epigenetic Regulation of the Gut-Brain Axis","volume":"13","author":"Stilling","year":"2014","journal-title":"Genes Brain Behav."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12974-020-1705-z","article-title":"The Progress of Gut Microbiome Research Related to Brain Disorders","volume":"17","author":"Zhu","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.advms.2017.04.005","article-title":"The Human Microbiome","volume":"62","author":"Blum","year":"2017","journal-title":"Adv. Med. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.1039\/D0FO01483D","article-title":"Phytochemicals as Modifiers of Gut Microbial Communities","volume":"11","author":"Dingeo","year":"2020","journal-title":"Food Funct."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu7010017","article-title":"The Impact of Diet and Lifestyle on Gut Microbiota and Human Health","volume":"7","author":"Conlon","year":"2014","journal-title":"Nutrients"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"(2012). Structure, Function and Diversity of the Healthy Human Microbiome. Nature, 486, 207\u2013214.","DOI":"10.1038\/nature11234"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of Human Gut Microbiome Correlates with Metabolic Markers","volume":"500","author":"Nielsen","year":"2013","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-161141","article-title":"The Gut Microbiota and Alzheimer\u2019s Disease","volume":"58","author":"Jiang","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1058709","article-title":"Commensal Host-Bacterial Relationships in the Gut","volume":"292","author":"Hooper","year":"2001","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","article-title":"The Gut Microbiome in Neurological Disorders","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.arr.2018.04.004","article-title":"Dysbiosis of Gut Microbiota and Microbial Metabolites in Parkinson\u2019s Disease","volume":"45","author":"Sun","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1007\/s00018-017-2550-9","article-title":"Microbiome, Probiotics and Neurodegenerative Diseases: Deciphering the Gut Brain Axis","volume":"74","author":"Westfall","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00401-018-1856-5","article-title":"Interplay among Gut Microbiota, Intestinal Mucosal Barrier and Enteric Neuro-Immune System: A Common Path to Neurodegenerative Diseases?","volume":"136","author":"Pellegrini","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1101\/gad.284091.116","article-title":"Metabolites: Messengers between the Microbiota and the Immune System","volume":"30","author":"Levy","year":"2016","journal-title":"Genes Dev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xu, J., and Chen, Y. (2021). Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 13.","DOI":"10.3390\/nu13062099"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cns.13116","article-title":"Mitochondrial Dysfunction in Neurodegenerative Diseases and the Potential Countermeasure","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"113681","DOI":"10.1016\/j.jpba.2020.113681","article-title":"Metabolomics Analysis of Microbiota-Gut-Brain Axis in Neurodegenerative and Psychiatric Diseases","volume":"194","author":"Konjevod","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hirschberg, S., Gisevius, B., Duscha, A., and Haghikia, A. (2019). Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20123109"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","article-title":"The Microbiome-Gut-Brain Axis in Health and Disease","volume":"46","author":"Dinan","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1113\/JP273106","article-title":"Gut Instincts: Microbiota as a Key Regulator of Brain Development, Ageing and Neurodegeneration","volume":"595","author":"Dinan","year":"2017","journal-title":"J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2147\/JPR.S168008","article-title":"The Increased Release of Amino Acid Neurotransmitters of the Primary Somatosensory Cortical Area in Rats Contributes to Remifentanil-Induced Hyperalgesia and Its Inhibition by Lidocaine","volume":"11","author":"Wang","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00018-017-2674-y","article-title":"Gut Microbiota Changes in the Extreme Decades of Human Life: A Focus on Centenarians","volume":"75","author":"Santoro","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter Modulation by the Gut Microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein\u2013Coupled Receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/ismej.2014.45","article-title":"Microbiome of Prebiotic-Treated Mice Reveals Novel Targets Involved in Host Response during Obesity","volume":"8","author":"Everard","year":"2014","journal-title":"ISME J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"263ra158","DOI":"10.1126\/scitranslmed.3009759","article-title":"The Gut Microbiota Influences Blood-Brain Barrier Permeability in Mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/nutrit\/nuab022","article-title":"Alzheimer\u2019s Disease and Gut Microbiota: Does Trimethylamine N-Oxide (TMAO) Play a Role?","volume":"80","author":"Spillane","year":"2022","journal-title":"Nutr. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuint.2018.08.005","article-title":"Unhealthy Gut, Unhealthy Brain: The Role of the Intestinal Microbiota in Neurodegenerative Diseases","volume":"120","author":"Spielman","year":"2018","journal-title":"Neurochem. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.nut.2009.07.006","article-title":"Butyrate and Propionate Induced Activated or Non-Activated Neutrophil Apoptosis via HDAC Inhibitor Activity but without Activating GPR-41\/GPR-43 Pathways","volume":"26","author":"Aoyama","year":"2010","journal-title":"Nutrition"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"836605","DOI":"10.3389\/fnins.2022.836605","article-title":"Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders","volume":"16","author":"Padhi","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"118627","DOI":"10.1016\/j.lfs.2020.118627","article-title":"Role of Gut-Brain Axis, Gut Microbial Composition, and Probiotic Intervention in Alzheimer\u2019s Disease","volume":"264","author":"Kesika","year":"2021","journal-title":"Life Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.tips.2012.07.002","article-title":"Inflammation and Neurodegeneration: The Story \u201cRetolled\u201d","volume":"33","author":"Cicchetti","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101664","DOI":"10.1016\/j.pneurobio.2019.101664","article-title":"microRNA Dysregulation in Neurodegenerative Diseases: A Systematic Review","volume":"182","author":"Drake","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia Development and Function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4161\/intv.22823","article-title":"In Vivo Dynamics of Innate Immune Sentinels in the CNS","volume":"1","author":"Nayak","year":"2012","journal-title":"Intravital"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host Microbiota Constantly Control Maturation and Function of Microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-Altering Microorganisms: The Impact of the Gut Microbiota on Brain and Behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Caputi, V., and Giron, M.C. (2018). Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson\u2019s Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061689"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chom.2007.09.013","article-title":"IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis","volume":"2","author":"Peterson","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00439-020-02237-0","article-title":"The Relationship between the Gut Microbiome and Host Gene Expression: A Review","volume":"140","author":"Nichols","year":"2021","journal-title":"Hum. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"689492","DOI":"10.1155\/2014\/689492","article-title":"dos S. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases","volume":"2014","author":"Ferreira","year":"2014","journal-title":"J. Immunol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The Microbiome and Innate Immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105314","DOI":"10.1016\/j.phrs.2020.105314","article-title":"The Impact of the Microbiota-Gut-Brain Axis on Alzheimer\u2019s Disease Pathophysiology","volume":"164","author":"Doifode","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer\u2019s Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-biochem-060713-035600","article-title":"Biosynthesis and Export of Bacterial Lipopolysaccharides","volume":"83","author":"Whitfield","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wu, L., Han, Y., Zheng, Z., Peng, G., Liu, P., Yue, S., Zhu, S., Chen, J., Lv, H., and Shao, L. (2021). Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer\u2019s Disease: Signals in Host-Microbe Interplay. Nutrients, 13.","DOI":"10.3390\/nu13010228"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and Functions of Inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/med.21653","article-title":"Expert Insights: The Potential Role of the Gut Microbiome-Bile Acid-Brain Axis in the Development and Progression of Alzheimer\u2019s Disease and Hepatic Encephalopathy","volume":"40","author":"Jia","year":"2020","journal-title":"Med. Res. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/e15041416","article-title":"Glyphosate\u2019s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases","volume":"15","author":"Samsel","year":"2013","journal-title":"Entropy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered Fecal Microbiota Composition in Patients with Major Depressive Disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases","volume":"10","author":"Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The Role of Short-Chain Fatty Acids in Health and Disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.numecd.2012.09.002","article-title":"The Role of Gut Microbiota in Human Obesity: Recent Findings and Future Perspectives","volume":"23","author":"Tagliabue","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The Role of Short-Chain Fatty Acids in Microbiota\u2013gut\u2013brain Communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e848","DOI":"10.1212\/WNL.0000000000013225","article-title":"Association of Fecal and Plasma Levels of Short-Chain Fatty Acids with Gut Microbiota and Clinical Severity in Patients With Parkinson Disease","volume":"98","author":"Chen","year":"2022","journal-title":"Neurology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1017\/S0954422415000037","article-title":"Towards Microbial Fermentation Metabolites as Markers for Health Benefits of Prebiotics","volume":"28","author":"Verbeke","year":"2015","journal-title":"Nutr. Res. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1089\/jmf.2014.7000","article-title":"The Gut Microbiome and the Brain","volume":"17","author":"Galland","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrendo.2015.128","article-title":"Short-Chain Fatty Acids in Control of Body Weight and Insulin Sensitivity","volume":"11","author":"Canfora","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"110112","DOI":"10.1016\/j.pnpbp.2020.110112","article-title":"Emerging Role of Gut Microbiota in Modulation of Neuroinflammation and Neurodegeneration with Emphasis on Alzheimer\u2019s Disease","volume":"106","author":"Goyal","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1080\/15548627.2019.1596489","article-title":"PSEN2 (presenilin 2) Mutants Linked to Familial Alzheimer Disease Impair Autophagy by Altering Ca2+ Homeostasis","volume":"15","author":"Fedeli","year":"2019","journal-title":"Autophagy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking Lipids to Alzheimer\u2019s Disease: Cholesterol and beyond","volume":"12","author":"Kim","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer Disease: Epidemiology, Diagnostic Criteria, Risk Factors and Biomarkers","volume":"88","author":"Reitz","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"633735","DOI":"10.3389\/fncel.2021.633735","article-title":"The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer\u2019s Disease","volume":"15","author":"Narengaowa","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e00632-19","DOI":"10.1128\/mBio.00632-19","article-title":"Alzheimer\u2019s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway","volume":"10","author":"Haran","year":"2019","journal-title":"MBio"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"120166","DOI":"10.1016\/j.jns.2022.120166","article-title":"Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer\u2019s or Parkinson\u2019s Disease Risk: A Systematic Review","volume":"434","author":"Solch","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_68","first-page":"147","article-title":"Morita Relationship between Alzheimer\u2019s Disease and the Human Microbiome","volume":"9","author":"Fujii","year":"2019","journal-title":"Exon Publ."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Pasinetti, G.M. (2022). Handbook of Microbiome and Gut-Brain-Axis in Alzheimer\u2019s Disease, IOS Press.","DOI":"10.3233\/AIAD9"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s40168-018-0439-y","article-title":"Microbiome-Host Systems Interactions: Protective Effects of Propionate upon the Blood-Brain Barrier","volume":"6","author":"Hoyles","year":"2018","journal-title":"Microbiome"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, Maintenance and Disruption of the Blood-Brain Barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1038\/s41598-019-43502-1","article-title":"Butyrate, a Metabolite of Intestinal Bacteria, Enhances Sleep","volume":"9","author":"Szentirmai","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.25982","article-title":"Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics","volume":"89","author":"Tan","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14737175.2018.1400909","article-title":"Protective Roles of Intestinal Microbiota Derived Short Chain Fatty Acids in Alzheimer\u2019s Disease-Type Beta-Amyloid Neuropathological Mechanisms","volume":"18","author":"Ho","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3390\/nu7042839","article-title":"Dietary Gut Microbial Metabolites, Short-Chain Fatty Acids, and Host Metabolic Regulation","volume":"7","author":"Kasubuchi","year":"2015","journal-title":"Nutrients"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.molcel.2016.10.025","article-title":"Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues","volume":"64","author":"Krautkramer","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2672.2012.05344.x","article-title":"\u03b3-Aminobutyric Acid Production by Culturable Bacteria from the Human Intestine","volume":"113","author":"Barrett","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mas.21553","article-title":"Mass Spectrometry-Based Metabolomics: Targeting the Crosstalk between Gut Microbiota and Brain in Neurodegenerative Disorders","volume":"38","author":"Luan","year":"2019","journal-title":"Mass Spectrom. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1021\/cn300186b","article-title":"A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin","volume":"4","author":"Baganz","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2005.07.013","article-title":"Dopamine by Itself Activates Either D2, D3 or D1\/D5 Dopaminergic Receptors in Normal Human T-Cells and Triggers the Selective Secretion of Either IL-10, TNFalpha or Both","volume":"169","author":"Besser","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0306-4522(85)90059-4","article-title":"Physiological Responses of Guinea-Pig Myenteric Neurons Secondary to the Release of Endogenous Serotonin by Tryptamine","volume":"16","author":"Takaki","year":"1985","journal-title":"Neuroscience"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin Signalling in the Gut--Functions, Dysfunctions and Therapeutic Targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1574-6976.2009.00204.x","article-title":"Indole as an Intercellular Signal in Microbial Communities","volume":"34","author":"Lee","year":"2010","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.chom.2016.10.021","article-title":"Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota","volume":"20","author":"Devlin","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial Tryptophan Catabolites in Health and Disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-immunol-032713-120245","article-title":"The Aryl Hydrocarbon Receptor: Multitasking in the Immune System","volume":"32","author":"Stockinger","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cofs.2018.03.004","article-title":"Redox Reactions in Food Fermentations","volume":"19","author":"Hansen","year":"2018","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tim.2016.02.002","article-title":"Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance","volume":"24","author":"Moya","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.phrs.2018.07.007","article-title":"Relevance of Gutmicrobiota in Cognition, Behaviour and Alzheimer\u2019s Disease","volume":"136","author":"Forlenza","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Huang, Y.-L., Lin, C.-H., Tsai, T.-H., Huang, C.-H., Li, J.-L., Chen, L.-K., Li, C.-H., Tsai, T.-F., and Wang, P.-N. (2021). Discovery of a Metabolic Signature Predisposing High Risk Patients with Mild Cognitive Impairment to Converting to Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222010903"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jalz.2018.08.012","article-title":"Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer\u2019s Disease: Relationship to Neuroimaging and CSF Biomarkers","volume":"15","author":"Nho","year":"2019","journal-title":"Alzheimers. Dement."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1097\/00001756-200006050-00032","article-title":"LPS-Induced Neuroinflammatory Effects Do Not Recover with Time","volume":"11","author":"Vraniak","year":"2000","journal-title":"Neuroreport"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of Brain Amyloidosis with pro-Inflammatory Gut Bacterial Taxa and Peripheral Inflammation Markers in Cognitively Impaired Elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fcimb.2015.00033","article-title":"New Insight into the Molecular Control of Bacterial Functional Amyloids","volume":"5","author":"Taylor","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JAD-142841","article-title":"Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration","volume":"45","author":"Friedland","year":"2015","journal-title":"J. Alzheimers. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jnutbio.2006.07.003","article-title":"Beta-Amyloid or Its Precursor Protein Is Found in Epithelial Cells of the Small Intestine and Is Stimulated by High-Fat Feeding","volume":"18","author":"Galloway","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1476-511X-8-46","article-title":"Amyloid-Beta Colocalizes with Apolipoprotein B in Absorptive Cells of the Small Intestine","volume":"8","author":"Galloway","year":"2009","journal-title":"Lipids Health Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/cen3.12401","article-title":"Helicobacter Pylori and Gut Microbiota in Multiple Sclerosis versus Alzheimer\u2019s Disease: 10 Pitfalls of Microbiome Studies","volume":"8","author":"Park","year":"2017","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Garcia, C.J., Kosek, V., Beltr\u00e1n, D., Tom\u00e1s-Barber\u00e1n, F.A., and Hajslova, J. (2022). Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota. Biomolecules, 12.","DOI":"10.3390\/biom12050687"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","article-title":"Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer\u2019s Disease-An Emerging Role for Gut Microbiome","volume":"15","author":"MahmoudianDehkordi","year":"2019","journal-title":"Alzheimers. Dement."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s Disease","volume":"5","author":"Breteler","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/mds.28052","article-title":"Microbiota Composition and Metabolism Are Associated with Gut Function in Parkinson\u2019s Disease","volume":"35","author":"Cirstea","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"155S","DOI":"10.1592\/phco.27.12part2.155S","article-title":"Overview of Parkinson\u2019s Disease","volume":"27","author":"Lew","year":"2007","journal-title":"Pharmacotherapy"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric Alpha-Synuclein Immunoreactive Inclusions in Meissner\u2019s and Auerbach\u2019s Plexuses in Cases Staged for Parkinson\u2019s Disease-Related Brain Pathology","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s Disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pharmthera.2015.11.012","article-title":"Gut Microbiome in Health and Disease: Linking the Microbiome-Gut-Brain Axis and Environmental Factors in the Pathogenesis of Systemic and Neurodegenerative Diseases","volume":"158","author":"Ghaisas","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-013-1214-6","article-title":"Accumulation of \u03b1-Synuclein in the Bowel of Patients in the Pre-Clinical Phase of Parkinson\u2019s Disease","volume":"127","author":"Hilton","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1111\/j.1365-2982.2012.01887.x","article-title":"A Comparison between Colonic Submucosa and Mucosa to Detect Lewy Pathology in Parkinson\u2019s Disease","volume":"24","author":"Pouclet","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1007\/s00018-018-2854-4","article-title":"Mechanisms of Protein Toxicity in Neurodegenerative Diseases","volume":"75","author":"Chung","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gutjnl-2018-316844","article-title":"Role of TLR4 in the Gut-Brain Axis in Parkinson\u2019s Disease: A Translational Study from Men to Mice","volume":"68","author":"Dodiya","year":"2019","journal-title":"Gut"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3233\/JPD-171103","article-title":"The Role of Lipids Interacting with \u03b1-Synuclein in the Pathogenesis of Parkinson\u2019s Disease","volume":"7","author":"Galvagnion","year":"2017","journal-title":"J. Parkinsons. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41531-021-00156-z","article-title":"Meta-Analysis of the Parkinson\u2019s Disease Gut Microbiome Suggests Alterations Linked to Intestinal Inflammation","volume":"7","author":"Romano","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson\u2019s Disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wallen, Z.D. (2021). Comparison Study of Differential Abundance Testing Methods Using Two Large Parkinson Disease Gut Microbiome Datasets Derived from 16S Amplicon Sequencing. BMC Bioinform., 22.","DOI":"10.1186\/s12859-021-04193-6"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e00561-20","DOI":"10.1128\/mSystems.00561-20","article-title":"Gut Microbiota and Metabolome Alterations Associated with Parkinson\u2019s Disease","volume":"5","author":"Vascellari","year":"2020","journal-title":"mSystems"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut Microbiota Are Related to Parkinson\u2019s Disease and Clinical Phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jam.13022","article-title":"Different Subtype Strains of Akkermansia Muciniphila Abundantly Colonize in Southern China","volume":"120","author":"Guo","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bpg.2017.09.011","article-title":"Action and Function of Faecalibacterium Prausnitzii in Health and Disease","volume":"31","author":"Andrade","year":"2017","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short Chain Fatty Acids and Gut Microbiota Differ between Patients with Parkinson\u2019s Disease and Age-Matched Controls","volume":"32","author":"Unger","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/mds.26942","article-title":"Parkinson\u2019s Disease and Parkinson\u2019s Disease Medications Have Distinct Signatures of the Gut Microbiome","volume":"32","author":"Debelius","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.parkreldis.2018.05.007","article-title":"Gut Microbiota in Patients with Parkinson\u2019s Disease in Southern China","volume":"53","author":"Lin","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/mds.27581","article-title":"Unraveling Gut Microbiota in Parkinson\u2019s Disease and Atypical Parkinsonism","volume":"34","author":"Barichella","year":"2019","journal-title":"Mov. Disord."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic Bacterial Composition in Parkinson\u2019s Disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-Chain Fatty Acids: Microbial Metabolites That Alleviate Stress-Induced Brain-Gut Axis Alterations","volume":"596","author":"Boehme","year":"2018","journal-title":"J. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.neuropharm.2012.01.026","article-title":"The Histone Deacetylase Inhibitor, Sodium Butyrate, Alleviates Cognitive Deficits in Pre-Motor Stage PD","volume":"62","author":"Rane","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jnutbio.2019.03.021","article-title":"Probiotics Mixture Increases Butyrate, and Subsequently Rescues the Nigral Dopaminergic Neurons from MPTP and Rotenone-Induced Neurotoxicity","volume":"69","author":"Srivastav","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Tran, S.M.-S., and Mohajeri, M.H. (2021). The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease. Nutrients, 13.","DOI":"10.3390\/nu13030732"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Minato, T., Maeda, T., Fujisawa, Y., Tsuji, H., Nomoto, K., Ohno, K., and Hirayama, M. (2017). Progression of Parkinson\u2019s Disease Is Associated with Gut Dysbiosis: Two-Year Follow-up Study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187307"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1039\/D2FO00552B","article-title":"Urolithins: Potential Biomarkers of Gut Dysbiosis and Disease Stage in Parkinson\u2019s Patients","volume":"13","author":"Herrero","year":"2022","journal-title":"Food Funct."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3389\/fmicb.2018.01967","article-title":"Butyrate Protects Mice Against Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels","volume":"9","author":"Ye","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Li, P., Killinger, B.A., Ensink, E., Beddows, I., Yilmaz, A., Lubben, N., Lamp, J., Schilthuis, M., Vega, I.E., and Woltjer, R. (2021). Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson\u2019s Disease. Metabolites, 11.","DOI":"10.3390\/metabo11010029"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JAD-210608","article-title":"Bile Acids as Key Modulators of the Brain-Gut-Microbiota Axis in Alzheimer\u2019s Disease","volume":"84","author":"Mulak","year":"2021","journal-title":"J. Alzheimers. Dis."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kiriyama, Y., and Nochi, H. (2019). The Biosynthesis, Signaling, and Neurological Functions of Bile Acids. Biomolecules, 9.","DOI":"10.3390\/biom9060232"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2019.10.035","article-title":"Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson\u2019s Disease","volume":"29","author":"Hertel","year":"2019","journal-title":"Cell Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00726-006-0375-1","article-title":"Taurine Release in Mouse Brain Stem Slices under Cell-Damaging Conditions","volume":"32","author":"Saransaari","year":"2007","journal-title":"Amino Acids"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-0-387-75681-3_17","article-title":"Mechanism of Neuroprotective Function of Taurine","volume":"643","author":"Wu","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"108807","DOI":"10.1016\/j.celrep.2021.108807","article-title":"Systematic Analysis of Gut Microbiome Reveals the Role of Bacterial Folate and Homocysteine Metabolism in Parkinson\u2019s Disease","volume":"34","author":"Rosario","year":"2021","journal-title":"Cell Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"103908","DOI":"10.1016\/j.isci.2022.103908","article-title":"Akkermansia Muciniphila Induces Mitochondrial Calcium Overload and \u03b1 -Synuclein Aggregation in an Enteroendocrine Cell Line","volume":"25","author":"Bosque","year":"2022","journal-title":"iScience"},{"key":"ref_140","unstructured":"Wolfe, M.S. (2018). The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms, Academic Press."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Faintuch, J., and Faintuch, S. (2019). Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications, Academic Press.","DOI":"10.1016\/B978-0-12-815249-2.02001-7"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Xia, Y., and Sun, J. (2022). An Integrated Analysis of Microbiomes and Metabolomics, American Chemical Society.","DOI":"10.1021\/acsinfocus.7e5035"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Ghezzi, L., Cantoni, C., Rotondo, E., and Galimberti, D. (2022). The Gut Microbiome-Brain Crosstalk in Neurodegenerative Diseases. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071486"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/imm.12903","article-title":"The Role of Gut Microbiome and Associated Metabolome in the Regulation of Neuroinflammation in Multiple Sclerosis and Its Implications in Attenuating Chronic Inflammation in Other Inflammatory and Autoimmune Disorders","volume":"154","author":"Dopkins","year":"2018","journal-title":"Immunology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-019-1434-3","article-title":"Impact of Microbiota on Central Nervous System and Neurological Diseases: The Gut-Brain Axis","volume":"16","author":"Ma","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., and Kim, S.-W. (2015). Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137429"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cell.2020.02.035","article-title":"Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism","volume":"180","author":"Duscha","year":"2020","journal-title":"Cell"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"a029017","DOI":"10.1101\/cshperspect.a029017","article-title":"The Gut Microbiome and Multiple Sclerosis","volume":"8","author":"Kirby","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e143774","DOI":"10.1172\/JCI143774","article-title":"Targeting the Gut to Treat Multiple Sclerosis","volume":"131","author":"Ghezzi","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fimmu.2019.00385","article-title":"Lactobacillus Reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut Microbiota","volume":"10","author":"He","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Navarro-L\u00f3pez, V., M\u00e9ndez-Miralles, M.\u00c1., Vela-Yebra, R., Fr\u00edes-Ramos, A., S\u00e1nchez-Pellicer, P., Ruzafa-Costas, B., N\u00fa\u00f1ez-Delegido, E., G\u00f3mez-G\u00f3mez, H., Chumillas-Lid\u00f3n, S., and Pic\u00f3-Monllor, J.A. (2022). Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis. Genes, 13.","DOI":"10.3390\/genes13050930"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T Cells and Immune Tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/jcp.25742","article-title":"TUDCA: An Agonist of the Bile Acid Receptor GPBAR1\/TGR5 With Anti-Inflammatory Effects in Microglial Cells","volume":"232","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.3748\/wjg.v24.i37.4217","article-title":"Focus on the Gut-Brain Axis: Multiple Sclerosis, the Intestinal Barrier and the Microbiome","volume":"24","author":"Metz","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1038\/ncomms12015","article-title":"Alterations of the Human Gut Microbiome in Multiple Sclerosis","volume":"7","author":"Jangi","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-981-13-8367-0_5","article-title":"Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis","volume":"1158","author":"Greco","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-019-1443-5","article-title":"Potential Roles of Gut Microbiome and Metabolites in Modulating ALS in Mice","volume":"572","author":"Blacher","year":"2019","journal-title":"Nature"},{"key":"ref_158","first-page":"dmm041947","article-title":"Temporal Evolution of the Microbiome, Immune System and Epigenome with Disease Progression in ALS Mice","volume":"13","author":"Guo","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Tilocca, B., Pieroni, L., Soggiu, A., Britti, D., Bonizzi, L., Roncada, P., and Greco, V. (2020). Gut-Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114045"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"603594","DOI":"10.3389\/fimmu.2020.603594","article-title":"Altered Gut Microbiota Related to Inflammatory Responses in Patients with Huntington\u2019s Disease","volume":"11","author":"Du","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"105199","DOI":"10.1016\/j.nbd.2020.105199","article-title":"An Integrated Metagenomics and Metabolomics Approach Implicates the Microbiota-Gut-Brain Axis in the Pathogenesis of Huntington\u2019s Disease","volume":"148","author":"Kong","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"104268","DOI":"10.1016\/j.nbd.2018.09.001","article-title":"Microbiome Profiling Reveals Gut Dysbiosis in a Transgenic Mouse Model of Huntington\u2019s Disease","volume":"135","author":"Kong","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nbd.2019.02.011","article-title":"Manipulation of Microbiota Reveals Altered Callosal Myelination and White Matter Plasticity in a Model of Huntington Disease","volume":"127","author":"Radulescu","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"fcaa110","DOI":"10.1093\/braincomms\/fcaa110","article-title":"Gut Dysbiosis in Huntington\u2019s Disease: Associations among Gut Microbiota, Cognitive Performance and Clinical Outcomes","volume":"2","author":"Wasser","year":"2020","journal-title":"Brain Commun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1523\/JNEUROSCI.20-12-04389.2000","article-title":"Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington\u2019s Disease","volume":"20","author":"Ferrante","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2011.05.006","article-title":"Gastrointestinal Dysfunction Contributes to Weight Loss in Huntington\u2019s Disease Mice","volume":"44","author":"Winqvist","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"McCourt, A.C., O\u2019Donovan, K.L., Ekblad, E., Sand, E., Craufurd, D., Rosser, A., Sanders, D., Stoy, N., Rickards, H., and Wierup, N. (2015). Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington\u2019s Disease. PLoS Curr., 7.","DOI":"10.1371\/currents.hd.858b4cc7f235df068387e9c20c436a79"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-019-0138-4","article-title":"Autism Spectrum Disorder","volume":"6","author":"Lord","year":"2020","journal-title":"Nat. Rev. Dis Primers"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/bies.201400075","article-title":"Altered Brain-Gut Axis in Autism: Comorbidity or Causative Mechanisms?","volume":"36","author":"Mayer","year":"2014","journal-title":"Bioessays"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Adams, J.B., Johansen, L.J., Powell, L.D., Quig, D., and Rubin, R.A. (2011). Gastrointestinal Flora and Gastrointestinal Status in Children with Autism--Comparisons to Typical Children and Correlation with Autism Severity. BMC Gastroenterol., 11.","DOI":"10.1186\/1471-230X-11-22"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Kang, D.-W., Park, J.G., Ilhan, Z.E., Wallstrom, G., Labaer, J., Adams, J.B., and Krajmalnik-Brown, R. (2013). Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068322"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D.I., Cristofori, F., Guerzoni, M.E., Gobbetti, M., and Francavilla, R. (2013). Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076993"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","article-title":"Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_175","first-page":"E4686","article-title":"HDAC1 Links Early Life Stress to Schizophrenia-like Phenotypes","volume":"114","author":"Varbanov","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.csbj.2022.02.024","article-title":"Analysis Methods for the Gut Microbiome in Neuropsychiatric and Neurodegenerative Disorders","volume":"20","author":"Song","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Aarts, E., Ederveen, T.H.A., Naaijen, J., Zwiers, M.P., Boekhorst, J., Timmerman, H.M., Smeekens, S.P., Netea, M.G., Buitelaar, J.K., and Franke, B. (2017). Gut Microbiome in ADHD and Its Relation to Neural Reward Anticipation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183509"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbr.2018.03.036","article-title":"Gut Microbiota Profiles in Treatment-Na\u00efve Children with Attention Deficit Hyperactivity Disorder","volume":"347","author":"Jiang","year":"2018","journal-title":"Behav. Brain Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaac.2013.11.013","article-title":"Inflammation in Children and Adolescents with Neuropsychiatric Disorders: A Systematic Review","volume":"53","author":"Mitchell","year":"2014","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_181","unstructured":"Martin, C.R., Preedy, V.R., and Rajendram, R. (2021). Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development, Academic Press."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Prehn-Kristensen, A., Zimmermann, A., Tittmann, L., Lieb, W., Schreiber, S., Baving, L., and Fischer, A. (2018). Reduced Microbiome Alpha Diversity in Young Patients with ADHD. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200728"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40168-020-00816-x","article-title":"Gut Microbiota from Persons with Attention-Deficit\/hyperactivity Disorder Affects the Brain in Mice","volume":"8","author":"Tengeler","year":"2020","journal-title":"Microbiome"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fpsyt.2020.00181","article-title":"A Pilot Randomized Control Trial with the Probiotic Strain Lactobacillus Rhamnosus GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life","volume":"11","author":"Kumperscak","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk","volume":"368","author":"Tang","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/ajcn\/nqy116","article-title":"Plasma Concentration of Trimethylamine-N-Oxide and Risk of Gestational Diabetes Mellitus","volume":"108","author":"Li","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.brainres.2016.03.042","article-title":"Clostridium Butyricum Attenuates Cerebral Ischemia\/reperfusion Injury in Diabetic Mice via Modulation of Gut Microbiota","volume":"1642","author":"Sun","year":"2016","journal-title":"Brain Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/nu5010058","article-title":"Role of Endogenous Microbiota, Probiotics and Their Biological Products in Human Health","volume":"5","author":"Howarth","year":"2013","journal-title":"Nutrients"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ijo.2011.27","article-title":"Childhood Overweight after Establishment of the Gut Microbiota: The Role of Delivery Mode, Pre-Pregnancy Weight and Early Administration of Antibiotics","volume":"35","author":"Ajslev","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s10620-020-06092-x","article-title":"Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions","volume":"65","author":"Davis","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.nut.2015.12.037","article-title":"Association between the Gut Microbiota and Diet: Fetal Life, Early Childhood, and Further Life","volume":"32","author":"Kashtanova","year":"2016","journal-title":"Nutrition"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3389\/fimmu.2017.00838","article-title":"The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces","volume":"8","author":"Statovci","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s13668-013-0041-7","article-title":"Mediterranean Diet and Minimizing Neurodegeneration","volume":"2","author":"Sofi","year":"2013","journal-title":"Curr. Nutr. Rep."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/jama.2009.1146","article-title":"Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia","volume":"302","author":"Samieri","year":"2009","journal-title":"JAMA"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"106270","DOI":"10.1016\/j.cct.2021.106270","article-title":"Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Study: Rationale, Design and Baseline Characteristics of a Randomized Control Trial of the MIND Diet on Cognitive Decline","volume":"102","author":"Liu","year":"2021","journal-title":"Contemp. Clin. Trials"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"12795","DOI":"10.1523\/JNEUROSCI.3520-09.2009","article-title":"Nutrition, Brain Aging, and Neurodegeneration","volume":"29","author":"Joseph","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3945\/an.114.007617","article-title":"Dietary Patterns, Cognitive Decline, and Dementia: A Systematic Review","volume":"6","author":"Berendsen","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","article-title":"Brain-Gut-Microbiota Axis in Parkinson\u2019s Disease","volume":"21","author":"Mulak","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.200","article-title":"Gut-Brain Axis in 2016: Brain-Gut-Microbiota Axis\u2014Mood, Metabolism and Behaviour","volume":"14","author":"Dinan","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Hori, T., Matsuda, K., and Oishi, K. (2020). Probiotics: A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut\u2013Brain Interaction. Microorganisms, 8.","DOI":"10.3390\/microorganisms8091401"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert Consensus Document. The International Scientific Association for Probiotics and Prebiotics Consensus Statement on the Scope and Appropriate Use of the Term Probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_203","unstructured":"Ravishankar, R.V., and Bai, J.A. (2014). Beneficial Microbes in Fermented and Functional Foods, CRC Press."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"950913","DOI":"10.3389\/fmicb.2022.950913","article-title":"Synbiotic Effects of Fermented Rice on Human Health and Wellness: A Natural Beverage That Boosts Immunity","volume":"13","author":"Fuloria","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ajcn\/74.6.833","article-title":"Enhancement of Immunity in the Elderly by Dietary Supplementation with the Probiotic Bifidobacterium Lactis HN019","volume":"74","author":"Gill","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3945\/ajcn.2008.26242","article-title":"Modulation of the Fecal Microflora Profile and Immune Function by a Novel Trans-Galactooligosaccharide Mixture (B-GOS) in Healthy Elderly Volunteers","volume":"88","author":"Vulevic","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_207","unstructured":"Floch, M.H., Ringel, Y., and Allen Walker, W. (2016). The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics, and Dysbiosis, Academic Press."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Hojsak, I., Kola\u010dek, S., Mihatsch, W., Mosca, A., Shamir, R., Szajewska, H., and Vandenplas, Y. (2022). Working Group on Probiotics and Prebiotics of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition* Synbiotics in The Management of Pediatric Gastrointestinal Disorders: Position Paper of the Espghan Special Interest Group on Gut Microbiota and Modifications. J. Pediatr. Gastroenterol. Nutr.","DOI":"10.1097\/MPG.0000000000003568"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Plaza-D\u00edaz, J., Ruiz-Ojeda, F.J., Vilchez-Padial, L.M., and Gil, A. (2017). Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases. Nutrients, 9.","DOI":"10.3390\/nu9060555"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","article-title":"Probiotic and Selenium Co-Supplementation, and the Effects on Clinical, Metabolic and Genetic Status in Alzheimer\u2019s Disease: A Randomized, Double-Blind, Controlled Trial","volume":"38","author":"Tamtaji","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_211","first-page":"70","article-title":"Bifidobacterium Breve A1 Supplementation Improved Cognitive Decline in Older Adults with Mild Cognitive Impairment: An Open-Label, Single-Arm Study","volume":"6","author":"Kobayashi","year":"2019","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2174\/1389201021666200107113812","article-title":"The Effects of Probiotics and Prebiotics on Mental Disorders: A Review on Depression, Anxiety, Alzheimer, and Autism Spectrum Disorders","volume":"21","author":"Ansari","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Zhu, G., Zhao, J., Zhang, H., Chen, W., and Wang, G. (2021). Administration of Bifidobacterium Breve Improves the Brain Function of A\u03b21-42-Treated Mice via the Modulation of the Gut Microbiome. Nutrients, 13.","DOI":"10.3390\/nu13051602"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnagi.2016.00256","article-title":"Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer\u2019s Disease: A Randomized, Double-Blind and Controlled Trial","volume":"8","author":"Akbari","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"8907","DOI":"10.1039\/D2FO01156E","article-title":"Psychobiotic Supplementation of HK-PS23 Improves Anxiety in Highly Stressed Clinical Nurses: A Double-Blind Randomized Placebo-Controlled Study","volume":"13","author":"Wu","year":"2022","journal-title":"Food Funct."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"614105","DOI":"10.3389\/fnut.2021.614105","article-title":"Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study","volume":"8","author":"Wu","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"827182","DOI":"10.3389\/fnut.2022.827182","article-title":"Probiotic Mixture Containing Lactobacillus Helveticus, Bifidobacterium Longum and Lactiplantibacillus Plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial","volume":"9","author":"Rode","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1139\/apnm-2021-0557","article-title":"Examining the Cognitive Benefits of Probiotic Supplementation in Physically Active Older Adults: A Randomized Clinical Trial","volume":"47","author":"Sanborn","year":"2022","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Sherman, H.T., Liu, K., Kwong, K., Chan, S.-T., Li, A.C., and Kong, X.-J. (2022). Carbon Monoxide (CO) Correlates with Symptom Severity, Autoimmunity, and Responses to Probiotics Treatment in a Cohort of Children with Autism Spectrum Disorder (ASD): A Post-Hoc Analysis of a Randomized Controlled Trial. BMC Psychiatry, 22.","DOI":"10.1186\/s12888-022-04151-3"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40814-020-0557-8","article-title":"Probiotics and Oxytocin Nasal Spray as Neuro-Social-Behavioral Interventions for Patients with Autism Spectrum Disorders: A Pilot Randomized Controlled Trial Protocol","volume":"6","author":"Kong","year":"2020","journal-title":"Pilot Feasibility Stud."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological Stress and Corticotropin-Releasing Hormone Increase Intestinal Permeability in Humans by a Mast Cell-Dependent Mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2031695","DOI":"10.1080\/19490976.2022.2031695","article-title":"Lactobacillus Rhamnosus CNCM I-3690 Decreases Subjective Academic Stress in Healthy Adults: A Randomized Placebo-Controlled Trial","volume":"14","author":"Wauters","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus Strain Regulates Emotional Behavior and Central GABA Receptor Expression in a Mouse via the Vagus Nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"15163","DOI":"10.3748\/wjg.v20.i41.15163","article-title":"Intestinal Microbiota in Health and Disease: Role of Bifidobacteria in Gut Homeostasis","volume":"20","author":"Tojo","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3389\/fneur.2020.01015","article-title":"Evaluation of an Immunomodulatory Probiotic Intervention for Veterans with Co-Occurring Mild Traumatic Brain Injury and Posttraumatic Stress Disorder: A Pilot Study","volume":"11","author":"Brenner","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cell.2016.06.001","article-title":"Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring","volume":"165","author":"Buffington","year":"2016","journal-title":"Cell"},{"key":"ref_227","first-page":"146","article-title":"Immune Modulation of the Brain-Gut-Microbe Axis","volume":"5","author":"Dinan","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-Brain Axis: How the Microbiome Influences Anxiety and Depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"412946","DOI":"10.1155\/2015\/412946","article-title":"Neuroprotective Effects of Clostridium Butyricum against Vascular Dementia in Mice via Metabolic Butyrate","volume":"2015","author":"Liu","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbr.2015.10.046","article-title":"Alteration of Behavior and Monoamine Levels Attributable to Lactobacillus Plantarum PS128 in Germ-Free Mice","volume":"298","author":"Liu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.celrep.2016.04.074","article-title":"Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis","volume":"15","author":"Mattei","year":"2016","journal-title":"Cell Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12991-017-0138-2","article-title":"The Effects of Probiotics on Depressive Symptoms in Humans: A Systematic Review","volume":"16","author":"Wallace","year":"2017","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"589","DOI":"10.5056\/jnm16018","article-title":"Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review","volume":"22","author":"Wang","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2174\/156652408784533779","article-title":"The Role of Microbiota and Probiotics in Stress-Induced Gastro-Intestinal Damage","volume":"8","author":"Lutgendorff","year":"2008","journal-title":"Curr. Mol. Med."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/nmo.12295","article-title":"Probiotic Gut Effect Prevents the Chronic Psychological Stress-Induced Brain Activity Abnormality in Mice","volume":"26","author":"Colom","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41398-022-01977-z","article-title":"Clinical, Gut Microbial and Neural Effects of a Probiotic Add-on Therapy in Depressed Patients: A Randomized Controlled Trial","volume":"12","author":"Schaub","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/bdi.12652","article-title":"Adjunctive Probiotic Microorganisms to Prevent Rehospitalization in Patients with Acute Mania: A Randomized Controlled Trial","volume":"20","author":"Dickerson","year":"2018","journal-title":"Bipolar Disord."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s13063-019-4040-x","article-title":"Treating Impulsivity with Probiotics in Adults (PROBIA): Study Protocol of a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial","volume":"21","author":"Bitter","year":"2020","journal-title":"Trials"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jad.2016.05.038","article-title":"Possible Association of Bifidobacterium and Lactobacillus in the Gut Microbiota of Patients with Major Depressive Disorder","volume":"202","author":"Aizawa","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.clnu.2018.04.010","article-title":"Effect of Probiotic and Prebiotic vs Placebo on Psychological Outcomes in Patients with Major Depressive Disorder: A Randomized Clinical Trial","volume":"38","author":"Kazemi","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.nut.2015.09.003","article-title":"Clinical and Metabolic Response to Probiotic Administration in Patients with Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"32","author":"Akkasheh","year":"2016","journal-title":"Nutrition"},{"key":"ref_242","first-page":"26294","article-title":"Effect of Probiotic Supplementation on Schizophrenia Symptoms and Association with Gastrointestinal Functioning: A Randomized, Placebo-Controlled Trial","volume":"16","author":"Dickerson","year":"2014","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bbi.2015.04.003","article-title":"A Randomized Controlled Trial to Test the Effect of Multispecies Probiotics on Cognitive Reactivity to Sad Mood","volume":"48","author":"Steenbergen","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.2044-8260.1992.tb00997.x","article-title":"The Development of a Six-Item Short-Form of the State Scale of the Spielberger State-Trait Anxiety Inventory (STAI)","volume":"31","author":"Marteau","year":"1992","journal-title":"Br. J. Clin. Psychol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s13311-018-0627-2","article-title":"Effects of Rifaximin on Central Responses to Social Stress-a Pilot Experiment","volume":"15","author":"Wang","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Cannavale, C.N., Mysonhimer, A.R., Bailey, M.A., Cohen, N.J., Holscher, H.D., and Khan, N.A. (2022). Consumption of a Fermented Dairy Beverage Improves Hippocampal-Dependent Relational Memory in a Randomized, Controlled Cross-over Trial. Nutr. Neurosci., 1\u201310.","DOI":"10.1080\/1028415X.2022.2046963"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"e772","DOI":"10.1212\/WNL.0000000000010998","article-title":"Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study","volume":"96","author":"Tan","year":"2021","journal-title":"Neurology"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.dld.2015.11.026","article-title":"Gastrointestinal Symptoms and Behavioral Problems in Preschoolers with Autism Spectrum Disorder","volume":"48","author":"Fulceri","year":"2016","journal-title":"Dig. Liver Dis."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Santocchi, E., Guiducci, L., Fulceri, F., Billeci, L., Buzzigoli, E., Apicella, F., Calderoni, S., Grossi, E., Morales, M.A., and Muratori, F. (2016). Gut to Brain Interaction in Autism Spectrum Disorders: A Randomized Controlled Trial on the Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters. BMC Psychiatry, 16.","DOI":"10.1186\/s12888-016-0887-5"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"550593","DOI":"10.3389\/fpsyt.2020.550593","article-title":"Effects of Probiotic Supplementation on Gastrointestinal, Sensory and Core Symptoms in Autism Spectrum Disorders: A Randomized Controlled Trial","volume":"11","author":"Santocchi","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"100277","DOI":"10.1016\/j.ynstr.2020.100277","article-title":"Lacticaseibacillus Paracasei Lpc-37\u00ae Improves Psychological and Physiological Markers of Stress and Anxiety in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled and Parallel Clinical Trial (the Sisu Study)","volume":"13","author":"Patterson","year":"2020","journal-title":"Neurobiol. Stress"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"23164","DOI":"10.4088\/PCC.19m02578","article-title":"Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"22","author":"Saccarello","year":"2020","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_253","doi-asserted-by":"crossref","unstructured":"Boulos, C., Yaghi, N., El Hayeck, R., Heraoui, G.N., and Fakhoury-Sayegh, N. (2019). Nutritional Risk Factors, Microbiota and Parkinson\u2019s Disease: What Is the Current Evidence?. Nutrients, 11.","DOI":"10.3390\/nu11081896"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/aje\/kwg073","article-title":"Dietary Intakes of Fat and Risk of Parkinson\u2019s Disease","volume":"157","author":"Chen","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"ref_255","first-page":"660","article-title":"Integrating Sex and Gender into Neurodegeneration Research: A Six-Component Strategy","volume":"3","author":"Tierney","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"146385","DOI":"10.1016\/j.brainres.2019.146385","article-title":"The Sex-Specific Interaction of the Microbiome in Neurodegenerative Diseases","volume":"1724","author":"Cox","year":"2019","journal-title":"Brain Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut Microbiome Alterations in Alzheimer\u2019s Disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbi.2014.10.018","article-title":"Gut Microbiome Composition Is Associated with Temperament during Early Childhood","volume":"45","author":"Christian","year":"2015","journal-title":"Brain Behav. Immun."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/3967\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:43Z","timestamp":1760143123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/14\/19\/3967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,24]]},"references-count":258,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["nu14193967"],"URL":"https:\/\/doi.org\/10.3390\/nu14193967","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,24]]}}}